Activity-based protein profiling for the functional annotation of enzymes (Q36954380)

17 August 2017

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title

Activity-based protein profiling for the functional annotation of enzymes (English)

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17 August 2017

2

Benjamin F Cravatt

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17 August 2017

Katherine T Barglow

1

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17 August 2017

publication date

1 October 2007

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17 August 2017

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17 August 2017

volume

4

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17 August 2017

issue

10

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17 August 2017

page(s)

822-827

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'Conserved hypothetical' proteins: prioritization of targets for experimental study

17 August 2017

cites work

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7 January 2021

Prediction of protein function from protein sequence and structure

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7 January 2021

Activity-based protein profiling: the serine hydrolases

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7 January 2021

Mechanism-based profiling of enzyme families

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7 January 2021

Tagging and detection strategies for activity-based proteomics.

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7 January 2021

Profiling serine hydrolase activities in complex proteomes

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7 January 2021

Direct visualization of serine hydrolase activities in complex proteomes using fluorescent active site-directed probes

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7 January 2021

Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools

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7 January 2021

Activity-based probes that target diverse cysteine protease families

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7 January 2021

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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7 January 2021

Activity-based probes for the proteomic profiling of metalloproteases

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7 January 2021

Developing photoactive affinity probes for proteomic profiling: hydroxamate-based probes for metalloproteases.

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7 January 2021

Proteomic profiling of metalloprotease activities with cocktails of active-site probes

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7 January 2021

Functional interrogation of the kinome using nucleotide acyl phosphates

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7 January 2021

A chemical approach for identifying O-GlcNAc-modified proteins in cells

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7 January 2021

Active-site peptide "fingerprinting" of glycosidases in complex mixtures by mass spectrometry. Discovery of a novel retaining beta-1,4-glycanase in Cellulomonas fimi

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7 January 2021

Activity-based probes for proteomic profiling of histone deacetylase complexes

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7 January 2021

Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype

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7 January 2021

Discovering disease-associated enzymes by proteome reactivity profiling

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7 January 2021

Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness

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7 January 2021

Mapping enzyme active sites in complex proteomes

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7 January 2021

High-resolution functional proteomics by active-site peptide profiling

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7 January 2021

A tandem orthogonal proteolysis strategy for high-content chemical proteomics

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7 January 2021

Chemical approaches for functionally probing the proteome

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7 January 2021

Discovering potent and selective reversible inhibitors of enzymes in complex proteomes

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7 January 2021

Large-scale prediction of protein structure and function from sequence.

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7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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7 January 2021

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.

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7 January 2021

Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family

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7 January 2021

A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae

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7 January 2021

Class assignment of sequence-unrelated members of enzyme superfamilies by activity-based protein profiling

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7 January 2021

Global analysis of proteasomal substrate specificity using positional-scanning libraries of covalent inhibitors.

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7 January 2021

Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes

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7 January 2021

Small molecule affinity fingerprinting. A tool for enzyme family subclassification, target identification, and inhibitor design

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7 January 2021

Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes

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7 January 2021

Substrate mimicry in an activity-based probe that targets the nitrilase family of enzymes

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7 January 2021

beta-Ureidopropionase deficiency: an inborn error of pyrimidine degradation associated with neurological abnormalities

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7 January 2021

A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases

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7 January 2021

An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling

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7 January 2021

Assignment of endogenous substrates to enzymes by global metabolite profiling

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7 January 2021

Data-mining approaches reveal hidden families of proteases in the genome of malaria parasite

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7 January 2021

A role for the protease falcipain 1 in host cell invasion by the human malaria parasite

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7 January 2021

Targeted disruption of Plasmodium falciparum cysteine protease, falcipain 1, reduces oocyst production, not erythrocytic stage growth

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7 January 2021

Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites

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7 January 2021

Microarray platform for profiling enzyme activities in complex proteomes

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7 January 2021

Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne [3 + 2] cycloaddition

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7 January 2021

A streamlined platform for high-content functional proteomics of primary human specimens

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7 January 2021

Proteomics evaluation of chemically cleavable activity-based probes

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7 January 2021

Catch-and-release reagents for broadscale quantitative proteomics analyses

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7 January 2021

Identifiers

DOI

10.1038/NMETH1092

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17 August 2017

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