The replication of beta cells in normal physiology, in disease and for therapy (Q36978813)

17 August 2017

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title

The replication of beta cells in normal physiology, in disease and for therapy (English)

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17 August 2017

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Peter C Butler

1

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17 August 2017

Juris J Meier

series ordinal

2

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17 August 2017

Alexandra E Butler

series ordinal

3

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17 August 2017

Anil Bhushan

series ordinal

4

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17 August 2017

publication date

1 November 2007

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Nature Clinical Practice Endocrinology and Metabolism

17 August 2017

published in

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17 August 2017

volume

3

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17 August 2017

issue

11

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17 August 2017

page(s)

758-768

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Preventing type 1 diabetes mellitus: hype and hope.

17 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

Quantitation of Endocrine Cell Content in the Pancreas of Nondiabetic and Diabetic Humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Classification of hypoglycemic disorders

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Beta-cell proliferation and apoptosis in the developing normal human pancreas and in hyperinsulinism of infancy

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Growth and regeneration of adult beta cells does not involve specialized progenitors.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Tissue-specific deletion of the retinoblastoma protein in the pancreatic beta-cell has limited effects on beta-cell replication, mass, and function.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

p16INK4a induces an age-dependent decline in islet regenerative potential

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

p27 Regulates the transition of beta-cells from quiescence to proliferation

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Very slow turnover of beta-cells in aged adult mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Molecular control of cell cycle progression in the pancreatic beta-cell

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Measurement of the kinetics of DNA repair synthesis after uv irradiation using immunochemical staining of incorporated 5-bromo-2'-deoxyuridine and flow cytometry

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

The Ki-67 protein: fascinating forms and an unknown function

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Validation of the use of proliferation markers in canine neoplastic and non-neoplastic tissues: comparison of KI-67 and proliferating cell nuclear antigen (PCNA) expression versus in vivo bromodeoxyuridine labelling by immunohistochemistry

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Ki-67 protein is associated with ribosomal RNA transcription in quiescent and proliferating cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Pancreatic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Epithelial-to-Mesenchymal Transition Generates Proliferative Human Islet Precursor Cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Hematopoietic stem cells derived from adult donors are not a source of pancreatic beta-cells in adult nondiabetic humans

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Limited capacity of human adult islets expanded in vitro to redifferentiate into insulin-producing beta-cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Bone marrow-derived stem cells initiate pancreatic regeneration.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

ADA Outstanding Scientific Achievement Lecture 2004. Thirty years of investigating the autoimmune basis for type 1 diabetes: why can't we prevent or reverse this disease?

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

The pancreas in recent-onset type 1 (insulin-dependent) diabetes mellitus: insulin content of islets, insulitis and associated changes in the exocrine acinar tissue

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Increased islet beta cell replication adjacent to intrapancreatic gastrinomas in humans.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration?

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Transient G2M arrest and subsequent release of apoptotic and mitotic cells in vanadyl(4)-prepulsed human Chang liver cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Apoptosis: an overview of the process and its relevance in disease.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Replication increases beta-cell vulnerability to human islet amyloid polypeptide-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

A genome-wide association study identifies novel risk loci for type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

The EXT2 multiple exostoses gene defines a family of putative tumour suppressor genes

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

The RNA-binding protein, Vg1RBP, is required for pancreatic fate specification.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Inhibition of cyclin-dependent kinase 5 activity protects pancreatic beta cells from glucotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Relationship between beta-cell mass and fasting blood glucose concentration in humans

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Glucose tolerance at age 58 and the decline of glucose tolerance in comparison with age 50 in people prenatally exposed to the Dutch famine.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Outcomes of pancreas transplants for patients with type 2 diabetes mellitus

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Normoglycemia and preserved insulin secretory reserve in diabetic patients 10-18 years after pancreas transplantation.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Relationship between diabetes and obesity 9 to 18 years after hemipancreatectomy and transplantation in donors and recipients

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Mechanisms of impaired fasting glucose and glucose intolerance induced by an approximate 50% pancreatectomy

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Deterioration of islet beta-cell function after hemipancreatectomy in dogs.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

The potential for stem cell therapy in diabetes.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Increased vulnerability of newly forming beta cells to cytokine-induced cell death.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk hispanic women

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Combination therapy with epidermal growth factor and gastrin increases beta-cell mass and reverses hyperglycemia in diabetic NOD mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

IGF-I and GH post-receptor signaling mechanisms for pancreatic beta-cell replication

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Glucagon-like peptide 1(GLP-1) in biology and pathology

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3'-kinase-dependent pathway.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

UKPDS 26: sulphonylurea failure in non-insulin-dependent diabetic patients over six years

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Sulfonylurea induced beta-cell apoptosis in cultured human islets

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

The direct effects of the angiotensin-converting enzyme inhibitors, zofenoprilat and enalaprilat, on isolated human pancreatic islets

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Effect of ramipril on the incidence of diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Decrease in beta-cell mass leads to impaired pulsatile insulin secretion, reduced postprandial hepatic insulin clearance, and relative hyperglucagonemia in the minipig

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Beta-cell deficit due to increased apoptosis in the human islet amyloid polypeptide transgenic (HIP) rat recapitulates the metabolic defects present in type 2 diabetes.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0647

7 January 2021

Identifiers

DOI

10.1038/NCPENDMET0647

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17 August 2017

1 reference