FXR signaling in metabolic disease (Q37006382)

17 August 2017

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title

FXR signaling in metabolic disease (English)

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17 August 2017

Yanqiao Zhang

1

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17 August 2017

Peter A Edwards

series ordinal

2

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17 August 2017

language of work or name

English

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publication date

20 November 2007

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17 August 2017

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17 August 2017

volume

582

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17 August 2017

issue

1

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17 August 2017

page(s)

10-18

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Identification of a nuclear receptor that is activated by farnesol metabolites

17 August 2017

cites work

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

The RXR heterodimers and orphan receptors

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

The farnesoid X receptor promotes adipocyte differentiation and regulates adipose cell function in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

FXR, a multipurpose nuclear receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

LXRS and FXR: the yin and yang of cholesterol and fat metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

The enzymes, regulation, and genetics of bile acid synthesis

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Endocrine functions of bile acids

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Identification of a nuclear receptor for bile acids

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Bile acids: natural ligands for an orphan nuclear receptor

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Endogenous bile acids are ligands for the nuclear receptor FXR/BAR

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

The nuclear hormone receptor farnesoid X receptor (FXR) is activated by androsterone

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Identification of a chemical tool for the orphan nuclear receptor FXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Identification of gene-selective modulators of the bile acid receptor FXR.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

The nuclear bile acid receptor FXR is activated by PGC-1alpha in a ligand-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Ligand-dependent coactivation of the human bile acid receptor FXR by the peroxisome proliferator-activated receptor gamma coactivator-1alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

The methyl transferase PRMT1 functions as co-activator of farnesoid X receptor (FXR)/9-cis retinoid X receptor and regulates transcription of FXR responsive genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Identification of DRIP205 as a coactivator for the Farnesoid X receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Glucose regulates the expression of the farnesoid X receptor in liver

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Redundant pathways for negative feedback regulation of bile acid production

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Identification of a hormonal basis for gallbladder filling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Prevention of cholesterol gallstone disease by FXR agonists in a mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Nuclear bile acid receptor FXR as pharmacological target: are we there yet?

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

The farnesoid X receptor modulates hepatic carbohydrate metabolism during the fasting-refeeding transition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

The farnesoid X-receptor is an essential regulator of cholesterol homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Loss of functional farnesoid X receptor increases atherosclerotic lesions in apolipoprotein E-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

FXR deficiency causes reduced atherosclerosis in Ldlr-/- mice

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Expression and activation of the farnesoid X receptor in the vasculature

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Downregulation of endothelin-1 by farnesoid X receptor in vascular endothelial cells

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Farnesoid X receptor is essential for normal glucose homeostasis

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Regulation of carbohydrate metabolism by the farnesoid X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Coordinated control of cholesterol catabolism to bile acids and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to-fed cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Transient impairment of the adaptive response to fasting in FXR-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

FXR: a target for cholestatic syndromes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Progressive familial intrahepatic cholestasis, type 1, is associated with decreased farnesoid X receptor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Reduced hepatic expression of farnesoid X receptor in hereditary cholestasis associated to mutation in ATP8B1

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

BSEP: function and role in progressive familial intrahepatic cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Heterozygous non-sense mutation of the MDR3 gene in familial intrahepatic cholestasis of pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

Benefit of farnesoid X receptor inhibition in obstructive cholestasis

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.11.015

10.1016/J.FEBSLET.2007.11.015

21 January 2018

Identifiers

DOI

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17 August 2017

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