Novel N7- and N1-substituted cGMP derivatives are potent activators of cyclic nucleotide-gated channels (Q37003246)

17 August 2017

Novel N7- and N1-substituted cGMP derivatives are potent activators of cyclic nucleotide-gated channels (English)

1 reference

17 August 2017

Timothy Strassmaier

1

1 reference

17 August 2017

Jeffrey W Karpen

series ordinal

2

1 reference

17 August 2017

language of work or name

English

0 references

publication date

1 August 2007

1 reference

Journal of Medicinal Chemistry

17 August 2017

1 reference

17 August 2017

50

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17 August 2017

17

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17 August 2017

4186-4194

1 reference

The pharmacology of cyclic nucleotide-gated channels: emerging from the darkness

17 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

Cell physiology of cAMP sensor Epac

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

Cyclic nucleotide-gated ion channels in sensory transduction.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

Modifications to the tetracaine scaffold produce cyclic nucleotide-gated channel blockers with widely varying efficacies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

Regulation of cyclic nucleotide-gated channels.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

Cyclic Nucleotide-Gated Ion Channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

Calcium, the two-faced messenger of olfactory transduction and adaptation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

Cyclic nucleotide-gated ion channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

Modulation of cyclic-nucleotide-gated channels and regulation of vertebrate phototransduction.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

Cyclic nucleotide analogs as biochemical tools and prospective drugs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

Cyclic nucleotide-gated channels in non-sensory organs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

The native rat olfactory cyclic nucleotide-gated channel is composed of three distinct subunits

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

Preparation of characterization of poly(ethylene glycol) vinyl sulfone

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

Specific labeling and permanent activation of the retinal rod cGMP-activated channel by the photoaffinity analog 8-p-azidophenacylthio-cGMP.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

Induction by cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segment

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

Interaction of hydrolysis-resistant analogs of cyclic GMP with the phosphodiesterase and light-sensitive channel of retinal rod outer segments

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

Antagonists of cyclic nucleotide-gated channels and molecular mapping of their site of action.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

A novel procedure for the synthesis of 2'-O-alkyl nucleotides.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

A carbon-13 and hydrogen-1 nuclear magnetic resonance study of the conformations of 3',5'- and 2',3'-cyclic nucleotides. A demonstration of the angular dependence of three-bond spin-spin couplings between carbon and phosphorus.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

Cyclic GMP directly regulates a cation conductance in membranes of bovine rods by a cooperative mechanism.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

Photoreceptor channel activation by nucleotide derivatives.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

Characterization of a novel isozyme of cGMP-dependent protein kinase from bovine aorta

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

15N nuclear magnetic resonance studies on the tautomerism of 8-hydroxy-2'-deoxyguanosine, 8-hydroxyguanosine, and other C8-substituted guanine nucleosides

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

Efficient synthesis of 8-thiosubstituted guanine derivatives as potential tools for biochemical and biological studies.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

Probing the interactions between cAMP and cGMP in cyclic nucleotide-gated channels using covalently tethered ligands

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

Molecular and pharmacological analysis of cyclic nucleotide-gated channel function in the central nervous system

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

Substituted cGMP analogs can act as selective agonists of the rod photoreceptor cGMP-gated cation channel

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

Identification of competitive antagonists of the rod photoreceptor cGMP-gated cation channel: beta-phenyl-1,N2-etheno-substituted cGMP analogues as probes of the cGMP-binding site

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597524

Reaction of guanosine with ethylating agents

4 September 2018

1 reference

12 December 2020

A proton magnetic resonance study of the conformations of 3',5'-cyclic nucleotides

1 reference

12 December 2020

Synthesis and biochemical studies of various 8-substituted derivatives of guanosine 3',5'-cyclic phosphate, inosine 3',5'-cyclic phosphate, and xanthosine 3',5'-cyclic phosphate

1 reference

12 December 2020

Effect of modification of the 1-, 2-, and 6-positions of 9-β-d-ribofuranosylpurine cyclic 3′,5′-phosphate on the cyclic nucleotide specificity of adenosine cyclic 3′,5′-phosphate-and guanosine cyclic 3′,5′-phosphate-dependent protein kinases

1 reference

12 December 2020

Binding stoichiometry of a fluorescent cGMP analogue to membranes of retinal rod outer segments

1 reference

12 December 2020

Studies of cGMP analog specificity and function of the two intrasubunit binding sites of cGMP-dependent protein kinase

1 reference

12 December 2020

Comparison of the two classes of binding sites (A and B) of type I and type II cyclic-AMP-dependent protein kinases by using cyclic nucleotide analogs

1 reference

12 December 2020

Spanning binding sites on allosteric proteins with polymer-linked ligand dimers

1 reference

12 December 2020

Relaxation of pig coronary arteries by new and potent cGMP analogs that selectively activate type I alpha, compared with type I beta, cGMP-dependent protein kinase

1 reference

12 December 2020

Activation of retinal rod cGMP-gated channels: What makes for an effective 8-substituted derivative of cGMP?

1 reference

12 December 2020

Small-molecule immunostimulants. Synthesis and activity of 7,8-disubstituted guanosines and structurally related compounds

1 reference

12 December 2020

Identifiers

DOI

10.1021/JM0702581

1 reference

17 August 2017

1 reference

17 August 2017

PubMed publication ID

17665892

1 reference