Origins and effects of extracellular alpha-synuclein: implications in Parkinson's disease (Q37044665)

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scientific article published on 17 April 2007

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English	Origins and effects of extracellular alpha-synuclein: implications in Parkinson's disease	scientific article published on 17 April 2007

Statements

instance of

scholarly article

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Europe PubMed Central

PubMed publication ID

18157654

retrieved

17 August 2017

review article

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Europe PubMed Central

title

Origins and effects of extracellular alpha-synuclein: implications in Parkinson's disease (English)

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Europe PubMed Central

PubMed publication ID

18157654

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17 August 2017

main subject

Parkinson's disease

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inferred from title

Synuclein

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author name string

Seung-Jae Lee

series ordinal

1

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Europe PubMed Central

PubMed publication ID

18157654

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17 August 2017

publication date

17 April 2007

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Europe PubMed Central

PubMed publication ID

18157654

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17 August 2017

published in

Journal of Molecular Neuroscience

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Europe PubMed Central

PubMed publication ID

18157654

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17 August 2017

volume

34

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Europe PubMed Central

PubMed publication ID

18157654

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17 August 2017

issue

1

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Europe PubMed Central

PubMed publication ID

18157654

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17 August 2017

page(s)

17-22

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Europe PubMed Central

PubMed publication ID

18157654

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17 August 2017

cites work

Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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The plasma alpha-synuclein levels in patients with Parkinson's disease and multiple system atrophy.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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Neurodegeneration and neuroprotection in Parkinson disease

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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Q64781356

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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Induction of neuronal cell death by Rab5A-dependent endocytosis of alpha-synuclein

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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Alpha-synuclein regulates neuronal survival via Bcl-2 family expression and PI3/Akt kinase pathway

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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Intravesicular localization and exocytosis of alpha-synuclein and its aggregates.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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The role of alpha-synuclein in Parkinson's disease: insights from animal models

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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alpha-Synuclein locus triplication causes Parkinson's disease

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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A peptide motif consisting of glycine, alanine, and valine is required for the fibrillization and cytotoxicity of human alpha-synuclein

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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Stages in the development of Parkinson's disease-related pathology

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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Phthalocyanine tetrasulfonates affect the amyloid formation and cytotoxicity of alpha-synuclein

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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The mystery of nonclassical protein secretion. A current view on cargo proteins and potential export routes

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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Protective effect of TAT-delivered alpha-synuclein: relevance of the C-terminal domain and involvement of HSP70.

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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Calcium(II) selectively induces alpha-synuclein annular oligomers via interaction with the C-terminal domain

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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The E46K mutation in alpha-synuclein increases amyloid fibril formation.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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Heparin and other glycosaminoglycans stimulate the formation of amyloid fibrils from alpha-synuclein in vitro.

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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Dependence of alpha-synuclein aggregate morphology on solution conditions

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18157654

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neural activity controls the synaptic accumulation of alpha-synuclein.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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inferred from PubMed ID database lookup

Exosomes: endosomal-derived vesicles shipping extracellular messages

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein and Parkinson's disease: selective neurodegenerative effect of alpha-synuclein fragment on dopaminergic neurons in vitro and in vivo

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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Transmissible spongiform encephalopathies, amyloidoses and yeast prions: common threads?

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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Neuropathology of Parkinson's disease

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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A novel mechanism of interaction between alpha-synuclein and biological membranes

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

based on heuristic

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Toxicity of non-abeta component of Alzheimer's disease amyloid, and N-terminal fragments thereof, correlates to formation of beta-sheet structure and fibrils

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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Amino acid sequence motifs and mechanistic features of the membrane translocation of alpha-synuclein

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18157654

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12 December 2020

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Identifiers

DOI

10.1007/S12031-007-0012-9

1 reference

stated in

Europe PubMed Central

PubMed publication ID

18157654

retrieved

17 August 2017

PubMed publication ID

18157654

1 reference

stated in

Europe PubMed Central

PubMed publication ID

18157654

retrieved

17 August 2017

 

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