Neurovascular signalling defects in neurodegeneration (Q37078102)

18 August 2017

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title

Neurovascular signalling defects in neurodegeneration (English)

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18 August 2017

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2

Diether Lambrechts

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18 August 2017

3

Peter Carmeliet

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18 August 2017

1

Serena Zacchigna

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18 August 2017

language of work or name

English

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publication date

1 March 2008

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Nature Reviews Neuroscience

18 August 2017

published in

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18 August 2017

volume

9

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18 August 2017

issue

3

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18 August 2017

page(s)

169-181

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Condensation of the central nervous system in embryonic Drosophila is inhibited by blocking hemocyte migration or neural activity

18 August 2017

cites work

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Caenorhabditis elegans receptors related to mammalian vascular endothelial growth factor receptors are expressed in neural cells

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Alzheimer's disease is a vasocognopathy: a new term to describe its nature

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Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia

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Angiogenesis in multiple sclerosis: is it good, bad or an epiphenomenon?

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Endothelial proliferation and increased blood-brain barrier permeability in the basal ganglia in a rat model of 3,4-dihydroxyphenyl-L-alanine-induced dyskinesia.

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Blood-brain barrier dysfunction in parkinsonian midbrain in vivo

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PET imaging of cerebral perfusion and oxygen consumption in acute ischaemic stroke: relation to outcome

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Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy

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Impaired endothelial function in coronary heart disease patients with depressive symptomatology

31 March 2020

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Endothelial dysfunction and the expression of endothelial nitric oxide synthetase in diabetic neuropathy, vascular disease, and foot ulceration

31 March 2020

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Therapeutic angiogenesis inhibits or rescues chemotherapy-induced peripheral neuropathy: taxol- and thalidomide-induced injury of vasa nervorum is ameliorated by VEGF.

31 March 2020

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Neurotrophins: roles in neuronal development and function

31 March 2020

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Brain-derived neurotrophic factor: a newly described mediator of angiogenesis

31 March 2020

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Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice

31 March 2020

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Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease.

31 March 2020

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Haploinsufficiency for trkB and trkC receptors induces cell loss and accumulation of alpha-synuclein in the substantia nigra

31 March 2020

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Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities

31 March 2020

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Blood vessels and nerves: common signals, pathways and diseases

31 March 2020

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Identification of novel mutations in the SEMA4A gene associated with retinal degenerative diseases

31 March 2020

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Mechanisms of angiogenesis and arteriogenesis

31 March 2020

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Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration.

31 March 2020

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VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death

31 March 2020

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Reduction of a vascular endothelial growth factor receptor, fetal liver kinase-1, by antisense oligonucleotides induces motor neuron death in rat spinal cord exposed to hypoxia

31 March 2020

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Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS.

31 March 2020

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VEGF-overexpressing transgenic mice show enhanced post-ischemic neurogenesis and neuromigration

31 March 2020

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Overexpression of mutant superoxide dismutase 1 causes a motor axonopathy in the zebrafish

31 March 2020

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Androgen receptor YAC transgenic mice recapitulate SBMA motor neuronopathy and implicate VEGF164 in the motor neuron degeneration

31 March 2020

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VEGF gene and phenotype relation with Alzheimer's disease and mild cognitive impairment.

31 March 2020

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Co-accumulation of vascular endothelial growth factor with beta-amyloid in the brain of patients with Alzheimer's disease

31 March 2020

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Disturbed cross talk between insulin-like growth factor I and AMP-activated protein kinase as a possible cause of vascular dysfunction in the amyloid precursor protein/presenilin 2 mouse model of Alzheimer's disease

31 March 2020

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Lack of hypoxia-inducible factor-1 alpha impairs midbrain neural precursor cells involving vascular endothelial growth factor signaling

31 March 2020

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Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury.

31 March 2020

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Mouse brains deficient in neuronal PDGF receptor-beta develop normally but are vulnerable to injury

31 March 2020

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ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis.

31 March 2020

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Another angiogenic gene linked to amyotrophic lateral sclerosis

31 March 2020

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A new role for angiogenin in neurite growth and pathfinding: implications for amyotrophic lateral sclerosis

31 March 2020

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Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

31 March 2020

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Progranulin is a mediator of the wound response

31 March 2020

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PC cell-derived growth factor (PCDGF/GP88, progranulin) stimulates migration, invasiveness and VEGF expression in breast cancer cells

31 March 2020

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Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology

31 March 2020

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Loss of TGF-beta 1 leads to increased neuronal cell death and microgliosis in mouse brain

31 March 2020

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Molecular and functional dissection of TGF-beta1-induced cerebrovascular abnormalities in transgenic mice

31 March 2020

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Reduced brain tissue perfusion in TGF-beta 1 transgenic mice showing Alzheimer's disease-like cerebrovascular abnormalities

31 March 2020

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TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.

31 March 2020

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Loss of basic fibroblast growth factor in substantia nigra neurons in Parkinson's disease

31 March 2020

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Whisker stimulation enhances angiogenesis in the barrel cortex following focal ischemia in mice

31 March 2020

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Autocrine VEGF signaling is required for vascular homeostasis

31 March 2020

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Direct evidence for endothelial vascular endothelial growth factor receptor-1 function in nitric oxide-mediated angiogenesis

31 March 2020

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Neurovascular mechanisms of Alzheimer's neurodegeneration

31 March 2020

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Transforming growth factor-beta1 upregulates the tight junction and P-glycoprotein of brain microvascular endothelial cells

31 March 2020

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Hepatocyte growth factor attenuates cerebral ischemia-induced increase in permeability of the blood-brain barrier and decreases in expression of tight junctional proteins in cerebral vessels.

31 March 2020

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Basic fibroblast growth factor modulates density of blood vessels and preserves tight junctions in organotypic cortical cultures of mice: a new in vitro model of the blood-brain barrier.

31 March 2020

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Functions of fibroblast growth factor (FGF)-2 and FGF-5 in astroglial differentiation and blood-brain barrier permeability: evidence from mouse mutants

31 March 2020

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HIF activation and VEGF overexpression are coupled with ZO-1 up-phosphorylation in the brain of dystrophic mdx mouse

31 March 2020

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Vascular endothelial growth factor (VEGF) in seizures: a double-edged sword

31 March 2020

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Blood-brain barrier disruption induces in vivo degeneration of nigral dopaminergic neurons

31 March 2020

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Excessive erythrocytosis in adult mice overexpressing erythropoietin leads to hepatic, renal, neuronal, and muscular degeneration

31 March 2020

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VEGF at the neurovascular interface: therapeutic implications for motor neuron disease

31 March 2020

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Fibroblast growth factor receptor-1 is required for long-term potentiation, memory consolidation, and neurogenesis

31 March 2020

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The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease

31 March 2020

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Depression of synaptic transmission by vascular endothelial growth factor in adult rat hippocampus and evidence for increased efficacy after chronic seizures.

31 March 2020

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Enhancement of ischemia-induced tyrosine phosphorylation of Kv1.2 by vascular endothelial growth factor via activation of phosphatidylinositol 3-kinase.

31 March 2020

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GDNF applied to the MPTP-lesioned nigrostriatal system requires TGF-beta for its neuroprotective action

31 March 2020

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A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor

31 March 2020

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Onset and progression in inherited ALS determined by motor neurons and microglia

31 March 2020

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Mutant Cu/Zn-superoxide dismutase associated with amyotrophic lateral sclerosis destabilizes vascular endothelial growth factor mRNA and downregulates its expression

31 March 2020

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Expanded polyglutamine peptides disrupt EGF receptor signaling and glutamate transporter expression in Drosophila.

31 March 2020

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Physiological function and putative therapeutic impact of the FGF-2 system in peripheral nerve regeneration--lessons from in vivo studies in mice and rats.

31 March 2020

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A neurovascular niche for neurogenesis after stroke.

31 March 2020

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VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants

31 March 2020

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VEGF links hippocampal activity with neurogenesis, learning and memory

31 March 2020

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VEGF is necessary for exercise-induced adult hippocampal neurogenesis

31 March 2020

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VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia

31 March 2020

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Coordinated interaction of neurogenesis and angiogenesis in the adult songbird brain.

31 March 2020

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Chronic stress in the adult dentate gyrus reduces cell proliferation near the vasculature and VEGF and Flk-1 protein expression.

31 March 2020

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Neural stem cells LewisX+ CXCR4+ modify disease progression in an amyotrophic lateral sclerosis model.

31 March 2020

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Chronically increased transforming growth factor-beta1 strongly inhibits hippocampal neurogenesis in aged mice

31 March 2020

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Ephrin-A2 reverse signaling negatively regulates neural progenitor proliferation and neurogenesis

31 March 2020

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EphrinB3 regulates cell proliferation and survival in adult neurogenesis

31 March 2020

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Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease

31 March 2020

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Vascular endothelial growth factor inhibits outward delayed-rectifier potassium currents in acutely isolated hippocampal neurons

31 March 2020

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Transforming growth factor-beta 1 regulates Kir2.3 inward rectifier K+ channels via phospholipase C and protein kinase C-delta in reactive astrocytes from adult rat brain

31 March 2020

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TGF-beta1-induced long-term changes in neuronal excitability in aplysia sensory neurons depend on MAPK

31 March 2020

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Hepatocyte growth factor as an enhancer of nmda currents and synaptic plasticity in the hippocampus

31 March 2020

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Interaction between interferon gamma and insulin-like growth factor-1 in hippocampus impacts on the ability of rats to sustain long-term potentiation

31 March 2020

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Epidermal growth factor and basic fibroblast growth factor promote the generation of long-term potentiation in the dentate gyrus of anaesthetized rats

31 March 2020

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Fibroblast growth factor-2 increases functional excitatory synapses on hippocampal neurons

31 March 2020

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Insulin-like growth factor-I promotes neurogenesis and synaptogenesis in the hippocampal dentate gyrus during postnatal development

31 March 2020

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The yin and yang of neurotrophin action

31 March 2020

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Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF

31 March 2020

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Terminal Schwann cells guide the reinnervation of muscle after nerve injury

31 March 2020

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The expression of the chemorepellent Semaphorin 3A is selectively induced in terminal Schwann cells of a subset of neuromuscular synapses that display limited anatomical plasticity and enhanced vulnerability in motor neuron disease

31 March 2020

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Target-derived trophic effect on skeletal muscle innervation in senescent mice

31 March 2020

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Muscle expression of a local Igf-1 isoform protects motor neurons in an ALS mouse model

31 March 2020

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IGF-I specifically enhances axon outgrowth of corticospinal motor neurons

31 March 2020

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Fibroblast growth factor-2 promotes axon branching of cortical neurons by influencing morphology and behavior of the primary growth cone.

31 March 2020

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Nerve sprouting in innervated adult skeletal muscle induced by exposure to elevated levels of insulin-like growth factors

31 March 2020

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Poor and protracted myelination as a contributory factor to neurodegenerative disorders

31 March 2020

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Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy

31 March 2020

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Combination of growth factors enhances remyelination in a cuprizone-induced demyelination mouse model.

31 March 2020

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Schwann cells express erythropoietin receptor and represent a major target for Epo in peripheral nerve injury

31 March 2020

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Insulin-like growth factor type 1 receptor signaling in the cells of oligodendrocyte lineage is required for normal in vivo oligodendrocyte development and myelination

31 March 2020

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PDGF and FGF2 pathways regulate distinct oligodendrocyte lineage responses in experimental demyelination with spontaneous remyelination

31 March 2020

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Insulin-like growth factor (IGF) signaling through type 1 IGF receptor plays an important role in remyelination

31 March 2020

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VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain

31 March 2020

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Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model.

31 March 2020

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VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model

31 March 2020

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Muscle-derived but not centrally derived transgene GDNF is neuroprotective in G93A-SOD1 mouse model of ALS.

31 March 2020

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IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1.

31 March 2020

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Vascular endothelial growth factor stimulates skeletal muscle regeneration in vivo

31 March 2020

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Fibroblast growth factor-2-producing fibroblasts protect the nigrostriatal dopaminergic system from 6-hydroxydopamine

31 March 2020

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Prevention of onset of Parkinson's disease by in vivo gene transfer of human hepatocyte growth factor in rodent model: a model of gene therapy for Parkinson's disease

31 March 2020

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The differences between high and low-dose administration of VEGF to dopaminergic neurons of in vitro and in vivo Parkinson's disease model

31 March 2020

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Enhanced vascularization and survival of neural transplants with ex vivo angiogenic gene transfer.

31 March 2020

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Enhanced survival, reinnervation, and functional recovery of intrastriatal dopamine grafts co-transplanted with Schwann cells overexpressing high molecular weight FGF-2 isoforms

31 March 2020

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Stem cells for the treatment of neurological disorders

31 March 2020

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FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntington's disease

31 March 2020

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Alterations in seizure susceptibility and in seizure-induced plasticity after pharmacologic and genetic manipulation of the fibroblast growth factor-2 system

31 March 2020

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Fibroblast growth factor-II gene therapy reverts the clinical course and the pathological signs of chronic experimental autoimmune encephalomyelitis in C57BL/6 mice.

31 March 2020

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Delayed administration of erythropoietin and its non-erythropoietic derivatives ameliorates chronic murine autoimmune encephalomyelitis.

31 March 2020

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Inhibition of Smad7, a negative regulator of TGF-beta signaling, suppresses autoimmune encephalomyelitis

31 March 2020

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Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease.

31 March 2020

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Growth factors and stroke

31 March 2020

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Nerve growth factor gene delivery: animal models to clinical trials

31 March 2020

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Vessels and nerves: marching to the same tune

31 March 2020

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Common mechanisms of nerve and blood vessel wiring

31 March 2020

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Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerve

31 March 2020

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Impaired angiogenesis in a transgenic mouse model of cerebral amyloidosis

31 March 2020

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Amyloid angiopathy-related vascular cognitive impairment.

31 March 2020

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Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, and misfolded proteins

31 March 2020

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Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease

31 March 2020

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Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein

31 March 2020

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Perfusion abnormalities in prodromal AD.

31 March 2020

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Neurovascular regulation in the normal brain and in Alzheimer's disease

31 March 2020

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Finding function in novel targets: C. elegans as a model organism

31 March 2020

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VEGF: multitasking in ALS

31 March 2020

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Endothelial signaling during development

31 March 2020

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Disruption of a single allele of the nerve growth factor gene results in atrophy of basal forebrain cholinergic neurons and memory deficits

31 March 2020

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PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling

31 March 2020

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Neurotrophic factors in neurodegenerative disorders: model of Parkinson's disease

31 March 2020

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Angels and demons: neurotrophic factors and epilepsy.

31 March 2020

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Hippocampal vulnerability following traumatic brain injury: a potential role for neurotrophin-4/5 in pyramidal cell neuroprotection

31 March 2020

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Mice heterozygous for neurotrophin-3 display enhanced vulnerability to excitotoxicity in the striatum through increased expression of N-methyl-D-aspartate receptors

31 March 2020

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Reversal of experimental diabetic neuropathy by VEGF gene transfer

31 March 2020

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Angiogenin activates Erk1/2 in human umbilical vein endothelial cells

31 March 2020

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Angiogenin activates human umbilical artery smooth muscle cells

31 March 2020

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Human angiogenin is a neuroprotective factor and amyotrophic lateral sclerosis associated angiogenin variants affect neurite extension/pathfinding and survival of motor neurons.

31 March 2020

1 reference

Initiation to end point: the multiple roles of fibroblast growth factors in neural development

31 March 2020

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TGF-{beta}1 activates two distinct type I receptors in neurons: implications for neuronal NF-{kappa}B signaling

31 March 2020

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Endocrine, liver-derived IGF-I is of importance for spatial learning and memory in old mice.

31 March 2020

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Mechanical stretch simulates proliferation of venous smooth muscle cells through activation of the insulin-like growth factor-1 receptor.

31 March 2020

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Genetic disruption of cortical interneuron development causes region- and GABA cell type-specific deficits, epilepsy, and behavioral dysfunction.

31 March 2020

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Overexpression of HGF retards disease progression and prolongs life span in a transgenic mouse model of ALS

31 March 2020

1 reference

Nonviral gene transfer of human hepatocyte growth factor improves streptozotocin-induced diabetic neuropathy in rats

31 March 2020

1 reference

Potential role of a novel vascular modulator, hepatocyte growth factor (HGF), in cardiovascular disease: characterization and regulation of local HGF system

31 March 2020

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Hepatocyte growth factor/scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons

31 March 2020

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Tumor endothelial cells express epidermal growth factor receptor (EGFR) but not ErbB3 and are responsive to EGF and to EGFR kinase inhibitors

31 March 2020

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Endogenous erythropoietin signaling is required for normal neural progenitor cell proliferation

31 March 2020

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Neuroprotective effects of erythropoietin in the rat hippocampus after pilocarpine-induced status epilepticus

31 March 2020

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Derivatives of erythropoietin that are tissue protective but not erythropoietic

31 March 2020

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Role of erythropoietin in the brain

31 March 2020

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Basic Fibroblast Growth Factor Selectively Increases AMPA‐Receptor Subunit GluR1 Protein Level and Differentially Modulates Ca2+ Responses to AMPA and NMDA in Hippocampal Neurons

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRN2336

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18 August 2017

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