Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening. (Q37088789)

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5 March 2020

title

Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening (English)

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2

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5 March 2020

author name string

Mark A Zaydman

1

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5 March 2020

Kelli Delaloye

3

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Yang Li

4

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5 March 2020

Hongwu Liang

5

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H Peter Larsson

6

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Jingyi Shi

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Jianmin Cui

8

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language of work or name

English

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publication date

16 July 2013

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Proceedings of the National Academy of Sciences of the United States of America

5 March 2020

published in

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volume

110

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issue

32

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page(s)

13180-13185

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IKs channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits

5 March 2020

cites work

1 reference

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Charge movement in gating-locked HCN channels reveals weak coupling of voltage sensors and gate.

29 September 2017

1 reference

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Regulation of voltage-gated potassium channels by PI(4,5)P2

29 September 2017

1 reference

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Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels

29 September 2017

1 reference

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Crystal Structure of the Mammalian GIRK2 K+ Channel and Gating Regulation by G Proteins, PIP2, and Sodium

29 September 2017

1 reference

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Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2

29 September 2017

1 reference

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Voltage-gated sodium channel (NaV) protein dissection creates a set of functional pore-only proteins.

29 September 2017

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The crystal structure of a voltage-gated sodium channel

29 September 2017

1 reference

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KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of IKs to modulate channel activity

29 September 2017

1 reference

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KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gate

29 September 2017

1 reference

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Molecular mechanism of allosteric modification of voltage-dependent sodium channels by local anesthetics

29 September 2017

1 reference

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State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activation

29 September 2017

1 reference

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Channelopathies linked to plasma membrane phosphoinositides.

29 September 2017

1 reference

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Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP.

29 September 2017

1 reference

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PIP2 is a necessary cofactor for ion channel function: how and why?

29 September 2017

1 reference

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A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate

29 September 2017

1 reference

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KCNE peptides differently affect voltage sensor equilibrium and equilibration rates in KCNQ1 K+ channels

29 September 2017

1 reference

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Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment

29 September 2017

1 reference

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Molecular characteristics of phosphoinositide binding

29 September 2017

1 reference

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Spectrum of pathogenic mutations and associated polymorphisms in a cohort of 44 unrelated patients with long QT syndrome

29 September 2017

1 reference

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A voltage sensor-domain protein is a voltage-gated proton channel

29 September 2017

1 reference

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A voltage-gated proton-selective channel lacking the pore domain

29 September 2017

1 reference

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Pathways modulating neural KCNQ/M (Kv7) potassium channels

29 September 2017

1 reference

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Subunit interaction determines IKs participation in cardiac repolarization and repolarization reserve

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740903

Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740903

Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740903

Spectrum and frequency of cardiac channel defects in swimming-triggered arrhythmia syndromes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740903

Ion conduction pore is conserved among potassium channels

29 September 2017

1 reference

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Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740903

Mutations in the S4 region isolate the final voltage-dependent cooperative step in potassium channel activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740903

Genomic structure of three long QT syndrome genes: KVLQT1, HERG, and KCNE1.

29 September 2017

1 reference

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Four novel KVLQT1 and four novel HERG mutations in familial long-QT syndrome

29 September 2017

1 reference

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Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740903

K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740903

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740903

Structural models for the KCNQ1 voltage-gated potassium channel

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740903

Role of the S6 C-terminus in KCNQ1 channel gating

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740903

Chromanol 293B binding in KCNQ1 (Kv7.1) channels involves electrostatic interactions with a potassium ion in the selectivity filter

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740903

The open pore conformation of potassium channels

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740903

Structure prediction for the down state of a potassium channel voltage sensor

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740903

Functional interactions at the interface between voltage-sensing and pore domains in the Shaker K(v) channel

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740903

Genetic testing in the long QT syndrome: development and validation of an efficient approach to genotyping in clinical practice.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740903

Voltage sensor of Kv1.2: structural basis of electromechanical coupling

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740903

PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740903

Transmembrane movement of the shaker K+ channel S4.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740903

Direct physical measure of conformational rearrangement underlying potassium channel gating

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740903

Novel mutations in KvLQT1 that affect Iks activation through interactions with Isk

3 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23861489

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hypokalemia-induced long QT syndrome with an underlying novel missense mutation in S4-S5 linker of KCNQ1

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23861489

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Gated access to the pore of a voltage-dependent K+ channel

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23861489

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1305167110

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23861489%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

0 references

1 reference

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5 March 2020

PubMed publication ID

23861489

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23861489%20AND%20SRC:MED&resulttype=core&format=json