Kinetic and structural characterization of amyloid-β peptide hydrolysis by human angiotensin-1-converting enzyme. (Q37107046)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26748546%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

title

Kinetic and structural characterization of amyloid-β peptide hydrolysis by human angiotensin-1-converting enzyme (English)

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4 March 2020

1

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4 March 2020

Geoffrey Masuyer

2

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4 March 2020

K. Ravi Acharya

5

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4 March 2020

author name string

Ross G Douglas

3

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4 March 2020

Sylva L Schwager

4

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4 March 2020

Edward D Sturrock

6

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4 March 2020

language of work or name

English

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publication date

9 February 2016

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4 March 2020

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4 March 2020

volume

283

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issue

6

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4 March 2020

page(s)

1060-1076

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Effects of oxidation on redox and cytotoxic properties of copper complex of Aβ1-16 peptide

4 March 2020

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14 September 2017

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Aβ1-16 can aggregate and induce the production of reactive oxygen species, nitric oxide, and inflammatory cytokines

14 September 2017

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Central angiotensin II stimulation promotes β amyloid production in Sprague Dawley rats

14 September 2017

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Blockade of brain angiotensin II AT1 receptors ameliorates stress, anxiety, brain inflammation and ischemia: Therapeutic implications

14 September 2017

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The N Domain of Human Angiotensin-I-converting Enzyme: THE ROLE OF N-GLYCOSYLATION AND THE CRYSTAL STRUCTURE IN COMPLEX WITH AN N DOMAIN-SPECIFIC PHOSPHINIC INHIBITOR, RXP407

14 September 2017

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The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia.

14 September 2017

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Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process

14 September 2017

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14 September 2017

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Abeta42-to-Abeta40- and angiotensin-converting activities in different domains of angiotensin-converting enzyme

14 September 2017

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Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction

14 September 2017

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14 September 2017

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A small region in the angiotensin-converting enzyme distal ectodomain is required for cleavage-secretion of the protein at the plasma membrane

14 September 2017

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Catabolic attacks of membrane-bound angiotensin-converting enzyme on the N-terminal part of species-specific amyloid-beta peptides

14 September 2017

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Brain renin angiotensin in disease

14 September 2017

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The N-domain of angiotensin-converting enzyme specifically hydrolyzes the Arg-5-His-6 bond of Alzheimer's Abeta-(1-16) peptide and its isoAsp-7 analogue with different efficiency as evidenced by quantitative matrix-assisted laser [...]

14 September 2017

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14 September 2017

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Structural changes of region 1-16 of the Alzheimer disease amyloid beta-peptide upon zinc binding and in vitro aging

14 September 2017

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Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor

14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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Crystal structure of the human angiotensin-converting enzyme-lisinopril complex

14 September 2017

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Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (A beta ); retards A beta aggregation, deposition, fibril formation; and inhibits cytotoxicity

14 September 2017

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Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

14 September 2017

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Angiotensin-converting enzyme and male fertility

14 September 2017

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The distal ectodomain of angiotensin-converting enzyme regulates its cleavage-secretion from the cell surface

14 September 2017

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Proteolytic release of membrane-bound angiotensin-converting enzyme: role of the juxtamembrane stalk sequence

14 September 2017

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Naturally occurring active N-domain of human angiotensin I-converting enzyme

14 September 2017

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The hemoregulatory peptide N-acetyl-Ser-Asp-Lys-Pro is a natural and specific substrate of the N-terminal active site of human angiotensin-converting enzyme

14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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Purification and characterization of recombinant human testis angiotensin-converting enzyme expressed in chinese hamster ovary cells

14 September 2017

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14 September 2017

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Angiotensin II-inhibiting drugs have no effect on intraneuronal Aβ or oligomeric Aβ levels in a triple transgenic mouse model of Alzheimer's disease.

29 September 2017

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Deglycosylation, processing and crystallization of human testis angiotensin-converting enzyme.

27 June 2018

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Peptidase specificity characterization of C- and N-terminal catalytic sites of angiotensin I-converting enzyme.

27 June 2018

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Zinc-induced dimerization of the amyloid-β metal-binding domain 1-16 is mediated by residues 11-14.

27 June 2018

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Angiotensin-converting enzyme levels and activity in Alzheimer's disease: differences in brain and CSF ACE and association with ACE1 genotypes.

3 September 2018

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3 September 2018

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A high-throughput fluorimetric assay for angiotensin I-converting enzyme

3 September 2018

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Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design.

3 September 2018

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The N domain of somatic angiotensin-converting enzyme negatively regulates ectodomain shedding and catalytic activity

3 September 2018

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The N-terminal active centre of human angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide.

3 September 2018

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3 September 2018

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Cortical alterations of angiotensin converting enzyme, angiotensin II and AT1 receptor in Alzheimer's dementia

3 September 2018

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Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

3 September 2018

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3 September 2018

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3 September 2018

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The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

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Combined use of selective inhibitors and fluorogenic substrates to study the specificity of somatic wild-type angiotensin-converting enzyme

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12 December 2020

Effects of the N-terminal sequence of ACE on the properties of its C-domain

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Angiotensin-converting enzyme converts amyloid beta-protein 1-42 (Abeta(1-42)) to Abeta(1-40), and its inhibition enhances brain Abeta deposition

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Identifiers

DOI

10.1111/FEBS.13647

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26748546%20AND%20SRC:MED&resulttype=core&format=json

release_aikalkx5tjetbjcrb57spdso34

4 March 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/aikalkx5tjetbjcrb57spdso34

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26748546%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

PubMed publication ID

26748546

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26748546%20AND%20SRC:MED&resulttype=core&format=json