Progressive apoptosis resistance prior to senescence and control by the anti-apoptotic protein BCL-xL. (Q37119578)

18 August 2017

Progressive apoptosis resistance prior to senescence and control by the anti-apoptotic protein BCL-xL. (English)

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18 August 2017

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Patrick J Rochette

1

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18 August 2017

Douglas E Brash

series ordinal

2

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18 August 2017

4 January 2008

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Mechanisms of Ageing and Development

18 August 2017

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18 August 2017

129

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18 August 2017

4

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18 August 2017

207-214

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describes a project that uses

18 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2652169/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Aging and genome maintenance

1 reference

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Mitochondrial apoptotic pathways.

14 September 2017

1 reference

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Apoptosis: a basic physiologic process in wound healing

14 September 2017

1 reference

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Pathways of apoptosis and importance in development.

14 September 2017

1 reference

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Transcription, apoptosis and p53: catch-22.

14 September 2017

1 reference

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UVB-induced apoptosis drives clonal expansion during skin tumor development

14 September 2017

1 reference

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Spontaneous immortalization of clinically normal colon-derived fibroblasts from a familial adenomatous polyposis patient

14 September 2017

1 reference

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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

14 September 2017

1 reference

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14 September 2017

Aging and wound healing

1 reference

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Regulation of apoptosis by Bcl‐2 family proteins

14 September 2017

1 reference

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The serial cultivation of human diploid cell strains

14 September 2017

1 reference

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Mad dogs, Englishmen and apoptosis: the role of cell death in UV-induced skin cancer

14 September 2017

1 reference

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p53 has a direct apoptogenic role at the mitochondria

14 September 2017

1 reference

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BH3-only proteins - evolutionarily conserved proapoptotic Bcl-2 family members essential for initiating programmed cell death.

14 September 2017

1 reference

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Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652169

Regulation of Bcl-xL: a little bit of this and a little bit of STAT.

14 September 2017

1 reference

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Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure

14 September 2017

1 reference

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bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652169

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652169

Bcl-XL and Bcl-2 repress a common pathway of cell death

14 September 2017

1 reference

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652169

Towards an understanding of the malignant transformation of diploid human fibroblasts

14 September 2017

1 reference

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Telomeres shorten during ageing of human fibroblasts

14 September 2017

1 reference

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Down-regulation of Bcl-XL by RNA interference suppresses cell growth and induces apoptosis in human esophageal cancer cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652169

Bcl-XL small interfering RNA enhances sensitivity of Hepg2 hepatocellular carcinoma cells to 5-fluorouracil and hydroxycamptothecin

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652169

RNA interference by expression of short hairpin RNAs suppresses bcl-xL gene expression in nasopharyngeal carcinoma cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652169

Increase in the ratio of mitochondrial Bax/Bcl-XL induces Bax activation in human leukemic K562 cell line

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652169

The somatic mutation theory of ageing

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652169

Expression of Bax, Bcl-2, Waf-1, and PCNA gene products in an immortalized human endothelial cell line undergoing p53-mediated apoptosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652169

29 September 2017

Apoptosis and cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652169

Downregulation of bcl-xL is relevant to UV-induced apoptosis in fibroblasts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652169

The role of cellular senescence in skin aging.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652169

Genomic organization, promoter region analysis, and chromosome localization of the mouse bcl-x gene.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652169

Mutagenicity and specific mutation spectrum induced by 8-methoxypsoralen plus a low dose of UVA in the hprt gene in diploid human fibroblasts.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652169

Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652169

Aging, longevity, and immortality in vitro

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652169

Induction of apoptosis and enhancement of chemosensitivity in human prostate cancer LNCaP cells using bispecific antisense oligonucleotide targeting Bcl-2 and Bcl-xL genes.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652169

Identification of a novel Bcl-xL phosphorylation site regulating the sensitivity of taxol- or 2-methoxyestradiol-induced apoptosis

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652169

Aphidicolin induces 6-thioguanine resistant mutants in human diploid fibroblasts

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652169

Aging is associated with increased proliferation and decreased apoptosis in the colonic mucosa

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652169

Reduction of UV-induced cell death in the human senescent fibroblasts.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652169

Bcl-xL is phosphorylated in malignant cells following microtubule disruption.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652169

Fas ligand: a sensor for DNA damage critical in skin cancer etiology

3 September 2018

1 reference

12 December 2020

Delayed wound healing in aged rats is associated with increased collagen gel remodeling and contraction by skin fibroblasts, not with differences in apoptotic or myofibroblast cell populations

1 reference

12 December 2020

A rapid rise in cell variants during the senescence of populations of human fibroblasts

1 reference

12 December 2020

The p53 functional circuit

1 reference

12 December 2020

p53 is preferentially recruited to the promoters of growth arrest genes p21 and GADD45 during replicative senescence of normal human fibroblasts

1 reference

12 December 2020

10.1016/J.MAD.2007.12.007

Identifiers

DOI

1 reference

18 August 2017

1 reference

18 August 2017

PubMed publication ID

18262222

1 reference