EWS-FLI1 suppresses NOTCH-activated p53 in Ewing's sarcoma (Q37135628)

18 August 2017

EWS-FLI1 suppresses NOTCH-activated p53 in Ewing's sarcoma (English)

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18 August 2017

5

Christopher Poremba

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18 August 2017

Heinrich Kovar

11

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author name string

Jozef Ban

1

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18 August 2017

Idriss M Bennani-Baiti

2

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18 August 2017

Max Kauer

3

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18 August 2017

Karl-Ludwig Schaefer

4

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18 August 2017

Gunhild Jug

6

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18 August 2017

Raphaela Schwentner

7

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18 August 2017

Oskar Smrzka

8

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18 August 2017

Karin Muehlbacher

9

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18 August 2017

Dave N T Aryee

10

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18 August 2017

language of work or name

English

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publication date

1 September 2008

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18 August 2017

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18 August 2017

68

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18 August 2017

17

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18 August 2017

7100-7109

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describes a project that uses

18 August 2017

limma

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22 June 2022

https://europepmc.org/article/PMC/4964910

inferred from PubMed Central ID database lookup

cites work

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Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer

14 September 2017

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Mesenchymal stem cell features of Ewing tumors

14 September 2017

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Inhibition of notch signaling induces neural differentiation in Ewing sarcoma

14 September 2017

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14 September 2017

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Notch signalling: a simple pathway becomes complex

14 September 2017

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Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma

14 September 2017

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Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation

14 September 2017

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Development of Ewing's sarcoma from primary bone marrow-derived mesenchymal progenitor cells

14 September 2017

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14 September 2017

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Context matters: the hen or egg problem in Ewing's sarcoma.

14 September 2017

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EWS-FLI1 target genes recovered from Ewing's sarcoma chromatin

14 September 2017

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p53: a heavily dictated dictator of life and death

14 September 2017

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14 September 2017

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EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3.

14 September 2017

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Coordinated activation of notch, Wnt, and transforming growth factor-beta signaling pathways in bone morphogenic protein 2-induced osteogenesis. Notch target gene Hey1 inhibits mineralization and Runx2 transcriptional activity

14 September 2017

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A new bone to pick: osteoblasts and the haematopoietic stem-cell niche

14 September 2017

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A gene atlas of the mouse and human protein-encoding transcriptomes

14 September 2017

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Identification of p53 regulators by genome-wide functional analysis

14 September 2017

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The role of Notch in tumorigenesis: oncogene or tumour suppressor?

14 September 2017

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Identification of p21WAF1/CIP1 as a direct target of EWS-Fli1 oncogenic fusion protein

14 September 2017

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Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma

14 September 2017

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A system for stable expression of short interfering RNAs in mammalian cells

14 September 2017

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Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964910

Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964910

Notch signaling induces cell cycle arrest in small cell lung cancer cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964910

Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964910

Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964910

Microarray analysis of Ewing's sarcoma family of tumours reveals characteristic gene expression signatures associated with metastasis and resistance to chemotherapy

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964910

Cholecystokinin down-regulation by RNA interference impairs Ewing tumor growth.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964910

Aberrant activation of notch signaling in human breast cancer

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964910

Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964910

Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964910

Targeting of EWS/FLI-1 by RNA interference attenuates the tumor phenotype of Ewing's sarcoma cells in vitro

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964910

EWS/ETS fusions activate telomerase in Ewing's tumors.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964910

Small interfering RNAs expressed from a Pol III promoter suppress the EWS/Fli-1 transcript in an Ewing sarcoma cell line

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964910

Response of Ewing tumor cells to forced and activated p53 expression

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964910

Among genes involved in the RB dependent cell cycle regulatory cascade, the p16 tumor suppressor gene is frequently lost in the Ewing family of tumors.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964910

The possible role of EWS-Fli1 in evasion of senescence in Ewing family tumors.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964910

Ewing sarcomas with p53 mutation or p16/p14ARF homozygous deletion: a highly lethal subset associated with poor chemoresponse

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964910

Narrow spectrum of infrequent p53 mutations and absence of MDM2 amplification in Ewing tumours.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964910

Notch-independent regulation of Hes-1 expression by c-Jun N-terminal kinase signaling in human endothelial cells

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964910

Smooth Muscle alpha-actin is a direct target of Notch/CSL

4 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18757425

12 December 2020

inferred from PubMed ID database lookup

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18757425

12 December 2020

inferred from PubMed ID database lookup

Prognostic impact of P53 status in Ewing sarcoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18757425

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1158/0008-5472.CAN-07-6145

1 reference

18 August 2017

1 reference

18 August 2017

PubMed publication ID

18757425

1 reference