Wild-type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse. (Q37154283)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19233858%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

title

Wild-type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse (English)

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21 January 2020

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2

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21 January 2020

Teepu Siddique

5

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21 January 2020

author name string

Lijun Wang

1

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21 January 2020

Gabriella Grisotti

3

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21 January 2020

Hong Zhai

4

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21 January 2020

Raymond P Roos

6

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21 January 2020

publication date

19 February 2009

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21 January 2020

published in

Human Molecular Genetics

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21 January 2020

volume

18

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21 January 2020

issue

9

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21 January 2020

page(s)

1642-1651

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A limited role for disulfide cross-linking in the aggregation of mutant SOD1 linked to familial amyotrophic lateral sclerosis.

21 January 2020

cites work

1 reference

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SOD1 and amyotrophic lateral sclerosis: mutations and oligomerization

6 September 2017

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Oxidized/misfolded superoxide dismutase-1: the cause of all amyotrophic lateral sclerosis?

6 September 2017

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Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis.

6 September 2017

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Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis

6 September 2017

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Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis

6 September 2017

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ALS: a disease of motor neurons and their nonneuronal neighbors

6 September 2017

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Mutant SOD1 instability: implications for toxicity in amyotrophic lateral sclerosis

6 September 2017

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Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria

6 September 2017

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Disulfide cross-linked protein represents a significant fraction of ALS-associated Cu, Zn-superoxide dismutase aggregates in spinal cords of model mice

6 September 2017

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Overloading of stable and exclusion of unstable human superoxide dismutase-1 variants in mitochondria of murine amyotrophic lateral sclerosis models

6 September 2017

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Unraveling the mechanisms involved in motor neuron degeneration in ALS

6 September 2017

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Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

6 September 2017

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Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

6 September 2017

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Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

6 September 2017

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Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity

6 September 2017

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Disulfide bond mediates aggregation, toxicity, and ubiquitylation of familial amyotrophic lateral sclerosis-linked mutant SOD1.

6 September 2017

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Neuroprotective effects of glial cell line-derived neurotrophic factor mediated by an adeno-associated virus vector in a transgenic animal model of amyotrophic lateral sclerosis.

14 September 2017

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ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

29 September 2017

1 reference

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Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment.

27 June 2018

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Human Cu/Zn superoxide dismutase (SOD1) overexpression in mice causes mitochondrial vacuolization, axonal degeneration, and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mut

3 September 2018

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Variation in the biochemical/biophysical properties of mutant superoxide dismutase 1 enzymes and the rate of disease progression in familial amyotrophic lateral sclerosis kindreds.

3 September 2018

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Axonal transport of mutant superoxide dismutase 1 and focal axonal abnormalities in the proximal axons of transgenic mice.

3 September 2018

1 reference

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Wild-type superoxide dismutase acquires binding and toxic properties of ALS-linked mutant forms through oxidation

3 September 2018

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12 December 2020

Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading

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12 December 2020

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

1 reference

12 December 2020

Truncated wild-type SOD1 and FALS-linked mutant SOD1 cause neural cell death in the chick embryo spinal cord

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12 December 2020

Identifiers

DOI

10.1093/HMG/DDP085

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19233858%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

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21 January 2020

PubMed publication ID

19233858

1 reference