Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover (Q37176385)

18 August 2017

Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover (English)

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18 August 2017

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N Ogata

1

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18 August 2017

D Chikazu

2

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18 August 2017

N Kubota

3

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18 August 2017

Y Terauchi

4

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18 August 2017

K Tobe

5

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18 August 2017

Y Azuma

6

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18 August 2017

T Ohta

7

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18 August 2017

T Kadowaki

8

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18 August 2017

K Nakamura

9

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18 August 2017

H Kawaguchi

10

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18 August 2017

language of work or name

English

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publication date

1 April 2000

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Journal of Clinical Investigation

18 August 2017

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18 August 2017

105

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18 August 2017

7

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18 August 2017

935-943

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The Gly972-->Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells

18 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

Modulating nuclear receptor function: may the phos be with you

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

Role of IRS-2 in insulin and cytokine signalling

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

Parathyroid hormone increases the concentration of insulin-like growth factor-I and transforming growth factor beta 1 in rat bone

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

Involutional osteoporosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

Mitogen-activated protein kinase inhibits 1,25-dihydroxyvitamin D3-dependent signal transduction by phosphorylating human retinoid X receptor alpha

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

Establishment and characterization of an immortal macrophage-like cell line inducible to differentiate to osteoclasts.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

Insulin receptor expression in bone

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

Insulin like growth factors and the local regulation of bone formation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

Characterization and function of the receptor for IGF-I in human preosteoclastic cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

Signal transduction mechanism of insulin and insulin-like growth factor-1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

Osteoblasts mediate insulin-like growth factor-I and -II stimulation of osteoclast formation and function

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

Demonstration of type I and type II somatomedin receptors on bovine growth plate chondrocytes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

Bone mineral density and bone metabolism in diabetes mellitus

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

Insulin-like growth factors and osteoporosis

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

Regulation of osteoclast function

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

Insulin-like growth factor-I supports formation and activation of osteoclasts

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

The association of obesity and glucose and insulin concentrations with bone density in premenopausal and postmenopausal women.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

Identification of a 190-kDa protein as a novel substrate for the insulin receptor kinase functionally similar to insulin receptor substrate-1.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

Correction of Abnormal Bone and Mineral Metabolism in Chronic Streptozotocin-Induced Diabetes Mellitus in the Rat by Insulin Therapy*

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=377487

Circulating and skeletal insulin-like growth factor-I (IGF-I) concentrations in two inbred strains of mice with different bone mineral densities

4 December 2018

1 reference

12 December 2020

Role of insulin receptor substrate-1 and pp60 in the regulation of insulin-induced glucose transport and GLUT4 translocation in primary adipocytes

1 reference

12 December 2020

Insulin receptor expression in primary and cultured osteoclast-like cells

1 reference

12 December 2020

Insulin-like growth factors and bone: the osteoporosis connection revisited

1 reference

12 December 2020

Molecular mechanism of a cross-talk between estrogen and growth-factor signaling pathways

1 reference

12 December 2020

Patients with Laron syndrome have Osteopenia/Osteoporosis

1 reference

12 December 2020

Ligand-independent recruitment of SRC-1 to estrogen receptor beta through phosphorylation of activation function AF-1

1 reference

12 December 2020

Identification and characterization of the insulin-like growth factor I receptor in mature rabbit osteoclasts

1 reference

12 December 2020

Bone mineral density in diabetes

1 reference

12 December 2020

Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor

1 reference

12 December 2020

Prostaglandin F2 alpha stimulates proliferation of clonal osteoblastic MC3T3-E1 cells by up-regulation of insulin-like growth factor I receptors

1 reference

12 December 2020

Proximal femur density in type 1 and 2 diabetic patients

1 reference

12 December 2020

Bone mineral density in patients with noninsulin-dependent diabetes mellitus by dual photon absorptiometry

1 reference

12 December 2020

Bone Density in Non-Insulin-Dependent Diabetes Mellitus: The Rotterdam Study

1 reference

12 December 2020

Serum IGF 1 is low and correlated with osteoblastic surface in idiopathic osteoporosis

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI9017

1 reference

18 August 2017

1 reference

18 August 2017

PubMed publication ID

10749573

1 reference