Regulation of TNFR1 and CD95 signalling by receptor compartmentalization (Q37188507)

18 August 2017

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title

Regulation of TNFR1 and CD95 signalling by receptor compartmentalization (English)

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18 August 2017

Stefan Schütze

1

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18 August 2017

Vladimir Tchikov

series ordinal

2

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18 August 2017

Wulf Schneider-Brachert

series ordinal

3

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18 August 2017

publication date

11 June 2008

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Nature Reviews Molecular Cell Biology

18 August 2017

published in

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18 August 2017

volume

9

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18 August 2017

issue

8

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18 August 2017

page(s)

655-662

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Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice

18 August 2017

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The odd couple: signal transduction and endocytosis

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Not just a sink: endosomes in control of signal transduction

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Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling

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Pathways of clathrin-independent endocytosis

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TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

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FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b.

31 March 2020

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FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

31 March 2020

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Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice

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TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survival

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TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells

31 March 2020

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Fas-associated Death Domain Protein and Caspase-8 Are Not Recruited to the Tumor Necrosis Factor Receptor 1 Signaling Complex during Tumor Necrosis Factor-induced Apoptosis

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Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

31 March 2020

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The TNF and TNF receptor superfamilies: integrating mammalian biology

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Tumor necrosis factor signaling.

31 March 2020

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Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling

31 March 2020

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Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles

31 March 2020

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Inhibition of TNF receptor 1 internalization by adenovirus 14.7K as a novel immune escape mechanism

31 March 2020

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The cytotoxicity of tumor necrosis factor depends on induction of the mitochondrial permeability transition

31 March 2020

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Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

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Role of acidic sphingomyelinase in Fas/CD95-mediated cell death.

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Sphingolipids and cell death.

31 March 2020

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Acid sphingomyelinase-derived ceramide is not required for inflammatory cytokine signalling in murine macrophages

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Perturbation of membrane microdomains reduces mitogenic signaling and increases susceptibility to apoptosis after T cell receptor stimulation

31 March 2020

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A novel cytoplasmic domain of the p55 tumor necrosis factor receptor initiates the neutral sphingomyelinase pathway

31 March 2020

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FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase

31 March 2020

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Activation of p42/p44 mitogen-activated protein kinases (MAPK) and p38 MAPK by tumor necrosis factor (TNF) is mediated through the death domain of the 55-kDa TNF receptor

31 March 2020

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TNF receptor death domain-associated proteins TRADD and FADD signal activation of acid sphingomyelinase

31 March 2020

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Requirement of FADD for tumor necrosis factor-induced activation of acid sphingomyelinase

31 March 2020

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Role of an acidic compartment in tumor-necrosis-factor-alpha-induced production of ceramide, activation of caspase-3 and apoptosis

31 March 2020

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Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation

31 March 2020

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Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

31 March 2020

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Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis

31 March 2020

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Acidic sphingomyelinase (ASM) is necessary for fas-induced GD3 ganglioside accumulation and efficient apoptosis of lymphoid cells

31 March 2020

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Fas/CD95/Apo-I activates the acidic sphingomyelinase via caspases.

31 March 2020

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TRAIL activates acid sphingomyelinase via a redox mechanism and releases ceramide to trigger apoptosis

31 March 2020

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The murine TRAIL receptor signals caspase-independent cell death through ceramide

31 March 2020

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Inhibition of receptor internalization attenuates the TNFα-induced ROS generation in non-phagocytic cells

31 March 2020

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Cathepsin D targeted by acid sphingomyelinase-derived ceramide

31 March 2020

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TNF-R1 signaling: a beautiful pathway

31 March 2020

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TNF-receptor I defective in internalization allows for cell death through activation of neutral sphingomyelinase

31 March 2020

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RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

31 March 2020

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TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

31 March 2020

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Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1

31 March 2020

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Distinct signaling pathways in TRAIL- versus tumor necrosis factor-induced apoptosis

31 March 2020

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The death domain kinase RIP mediates the TNF-induced NF-kappaB signal

31 March 2020

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The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation

31 March 2020

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CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation

31 March 2020

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Function and regulation of the CD95 (APO-1/Fas) ligand in the immune system

31 March 2020

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The CD95 Receptor: Apoptosis Revisited

31 March 2020

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Molecular ordering of the initial signaling events of CD95.

31 March 2020

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Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling

31 March 2020

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SPOTS: signaling protein oligomeric transduction structures are early mediators of death receptor-induced apoptosis at the plasma membrane

31 March 2020

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The role of receptor internalization in CD95 signaling

31 March 2020

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CD95 death-inducing signaling complex formation and internalization occur in lipid rafts of type I and type II cells.

31 March 2020

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Palmitoylation is required for efficient Fas cell death signaling

31 March 2020

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CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway

31 March 2020

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Regulating Vav1 phosphorylation by the SHP-1 tyrosine phosphatase is a fine-tuning mechanism for the negative regulation of DISC formation and Fas-mediated cell death signaling

31 March 2020

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CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells

31 March 2020

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Non-apoptotic signaling pathways activated by soluble Fas ligand in serum-starved human fibroblasts. Mitogen-activated protein kinases and NF-kappaB-dependent gene expression.

31 March 2020

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The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

31 March 2020

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The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation.

31 March 2020

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Palmitoylation of intracellular signaling proteins: regulation and function

31 March 2020

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Death-receptor activation halts clathrin-dependent endocytosis

31 March 2020

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Receptor-mediated endocytosis is not required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM2430

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Dimensions Publication ID

18 August 2017

1019213829

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