Targeted knock-in mice expressing mutations of CD28 reveal an essential pathway for costimulation (Q37233454)

19 August 2017

Targeted knock-in mice expressing mutations of CD28 reveal an essential pathway for costimulation (English)

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19 August 2017

Lindzy F Dodson

1

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19 August 2017

Jonathan S Boomer

2

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19 August 2017

Christine M Deppong

3

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19 August 2017

Dulari D Shah

4

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19 August 2017

Julia Sim

5

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19 August 2017

Traci L Bricker

6

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19 August 2017

John H Russell

7

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19 August 2017

Jonathan M Green

8

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19 August 2017

language of work or name

English

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publication date

27 April 2009

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Molecular and Cellular Biology

19 August 2017

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19 August 2017

29

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19 August 2017

13

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19 August 2017

3710-3721

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describes a project that uses

19 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2698768/fullTextXML

inferred from PubMed Central ID database lookup

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Cutting edge: CD28-mediated transcriptional and posttranscriptional regulation of IL-2 expression are controlled through different signaling pathways

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Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells

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Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation

6 September 2017

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Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway

6 September 2017

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Regulation of Akt/PKB activation by tyrosine phosphorylation

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Complex formation and cooperation of protein kinase C theta and Akt1/protein kinase B alpha in the NF-kappa B transactivation cascade in Jurkat T cells

6 September 2017

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Critical requirement for the membrane-proximal cytosolic tyrosine residue for CD28-mediated costimulation in vivo

6 September 2017

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Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines

6 September 2017

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Cellular signaling: pivoting around PDK-1.

6 September 2017

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Negative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3

6 September 2017

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Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo

6 September 2017

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Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis

6 September 2017

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Proline residues in CD28 and the Src homology (SH)3 domain of Lck are required for T cell costimulation

6 September 2017

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Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)

6 September 2017

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Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction

6 September 2017

1 reference

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Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB.

6 September 2017

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Growth factor receptor-bound protein 2 SH2/SH3 domain binding to CD28 and its role in co-signaling

6 September 2017

1 reference

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

6 September 2017

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Two distinct intracytoplasmic regions of the T-cell adhesion molecule CD28 participate in phosphatidylinositol 3-kinase association

6 September 2017

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CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

6 September 2017

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Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation

6 September 2017

1 reference

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p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698768

T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression

6 September 2017

1 reference

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CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines

6 September 2017

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Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

6 September 2017

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TcR and TcR-CD28 engagement of protein kinase B (PKB/AKT) and glycogen synthase kinase-3 (GSK-3) operates independently of guanine nucleotide exchange factor VAV-1.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698768

Role for protein kinase Ctheta (PKCtheta) in TCR/CD28-mediated signaling through the canonical but not the non-canonical pathway for NF-kappaB activation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698768

Dual regulation of glycogen synthase kinase-3beta by the alpha1A-adrenergic receptor

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698768

Ligation of the T cell co-stimulatory receptor CD28 activates the serine-threonine protein kinase protein kinase B.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698768

Signaling through CD28/CTLA-4 family receptors: puzzling participation of phosphatidylinositol-3 kinase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698768

Regulation of protein kinase Ctheta function during T cell activation by Lck-mediated tyrosine phosphorylation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698768

The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698768

Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698768

Cytokine-stimulated phosphorylation of GSK-3 is primarily dependent upon PKCs, not PKB.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698768

Costimulation blockade with belatacept in renal transplantation

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698768

Regulation of Akt/PKB Ser473 phosphorylation

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698768

Requirement for CD28 in the effector phase of allergic airway inflammation

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698768

Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698768

Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698768

Antigen-induced translocation of PKC-theta to membrane rafts is required for T cell activation

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698768

Cutting edge: distinct motifs within CD28 regulate T cell proliferation and induction of Bcl-XL.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698768

A point mutation in CD28 distinguishes proliferative signals from survival signals

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698768

CD28 and CTLA4 coordinately regulate airway inflammatory cell recruitment and T-helper cell differentiation after inhaled allergen

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698768

Absence of B7-dependent responses in CD28-deficient mice

20 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698768

Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition

20 October 2018

1 reference

12 December 2020

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

1 reference

12 December 2020

CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells

1 reference

12 December 2020

Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway

1 reference

12 December 2020

Characterization of a murine model of allergic pulmonary inflammation

1 reference

12 December 2020

Identifiers

DOI

10.1128/MCB.01869-08

1 reference

19 August 2017

1 reference

19 August 2017

PubMed publication ID

19398586

1 reference