Human Hp1-1 and Hp2-2 phenotype-specific haptoglobin therapeutics are both effective in vitro and in guinea pigs to attenuate hemoglobin toxicity. (Q37258295)

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scientific article published on 28 March 2013

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English	Human Hp1-1 and Hp2-2 phenotype-specific haptoglobin therapeutics are both effective in vitro and in guinea pigs to attenuate hemoglobin toxicity.	scientific article published on 28 March 2013

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24 February 2020

Human Hp1-1 and Hp2-2 phenotype-specific haptoglobin therapeutics are both effective in vitro and in guinea pigs to attenuate hemoglobin toxicity (English)

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24 February 2020

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24 February 2020

Dominik J. Schaer

6

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24 February 2020

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Miriam Lipiski

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24 February 2020

Jin Hyen Baek

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24 February 2020

Wolfgang R Engelsberger

4

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24 February 2020

Paul W Buehler

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24 February 2020

publication date

28 March 2013

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24 February 2020

Antioxidants & Redox Signaling

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24 February 2020

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24 February 2020

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24 February 2020

1619-1633

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24 February 2020

describes a project that uses

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11 June 2022

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Haptoglobin genotype is a consistent marker of coronary heart disease risk among individuals with elevated glycosylated hemoglobin

1 reference

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Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

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Structure of the haptoglobin-haemoglobin complex

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6 September 2017

Trapping of human hemoglobin by haptoglobin: molecular mechanisms and clinical applications

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Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine β145

1 reference

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6 September 2017

Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy.

1 reference

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6 September 2017

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6 September 2017

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1 reference

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6 September 2017

Haptoglobin: basic and clinical aspects

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1 reference

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6 September 2017

Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs

1 reference

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1 reference

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6 September 2017

CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin

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Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease

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6 September 2017

Identification of the haemoglobin scavenger receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809386

6 September 2017

Role of hemopexin in protection of low-density lipoprotein against hemoglobin-induced oxidation

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6 September 2017

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809386

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Genetically determined heterogeneity in hemoglobin scavenging and susceptibility to diabetic cardiovascular disease

1 reference

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Red cells, hemoglobin, heme, iron, and atherogenesis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809386

26 June 2018

Plasma clearance of hemoglobin and haptoglobin in mice and effect of CD163 gene targeting disruption

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809386

3 September 2018

Haptoglobin genotype is a major determinant of the amount of iron in the human atherosclerotic plaque

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809386

3 September 2018

Downregulation of the hemoglobin scavenger receptor in individuals with diabetes and the Hp 2-2 genotype: implications for the response to intraplaque hemorrhage and plaque vulnerability.

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CD163-expressing monocytes constitute an endotoxin-sensitive Hb clearance compartment within the vascular system.

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Constitutive endocytosis of CD163 mediates hemoglobin-heme uptake and determines the noninflammatory and protective transcriptional response of macrophages to hemoglobin

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Haptoglobin genotype- and diabetes-dependent differences in iron-mediated oxidative stress in vitro and in vivo

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Fast determination of haptoglobin phenotype and calculation of hemoglobin binding capacity using high pressure gel permeation chromatography

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Quantitative mass spectrometry defines an oxidative hotspot in hemoglobin that is specifically protected by haptoglobin

1 reference

https://pubmed.ncbi.nlm.nih.gov/23418677

12 December 2020

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Increased Expression of Oxidation-Specific Epitopes and Apoptosis Are Associated With Haptoglobin Genotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/23418677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Haptoglobin alters oxygenation and oxidation of hemoglobin and decreases propagation of peroxide-induced oxidative reactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/23418677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rate of haptoglobin in synthesis in normal man. Determinations by the return to normal levels following hemoglobin infusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/23418677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elimination from rat circulation of goat and sheep haptoglobin and their complexes with rat haemoglobin

1 reference

https://pubmed.ncbi.nlm.nih.gov/23418677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elimination of goat haemoglobin and its complexes with goat haptoglobin from goat and rat circulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23418677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hemin: a possible physiological mediator of low density lipoprotein oxidation and endothelial injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/23418677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stability of the heme-globin linkage in alphabeta dimers and isolated chains of human hemoglobin. A study of the heme transfer reaction from the immobilized proteins to albumin

1 reference

https://pubmed.ncbi.nlm.nih.gov/23418677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Permeability characteristics of hemoglobin derivatives across cultured endothelial cell monolayers

1 reference

https://pubmed.ncbi.nlm.nih.gov/23418677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification

1 reference

https://pubmed.ncbi.nlm.nih.gov/23418677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1089/ARS.2012.5089

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Europe PubMed Central

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24 February 2020

PMC publication ID

1 reference

Europe PubMed Central

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24 February 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23418677%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

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