Microbial drug discovery: 80 years of progress (Q37365189)

19 August 2017

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title

Microbial drug discovery: 80 years of progress (English)

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19 August 2017

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Arnold L Demain

1

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19 August 2017

Sergio Sanchez

series ordinal

2

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19 August 2017

publication date

9 January 2009

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The Journal of Antibiotics

19 August 2017

published in

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19 August 2017

volume

62

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19 August 2017

issue

1

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19 August 2017

page(s)

5-16

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Biotechnological advantages of laboratory-scale solid-state fermentation with fungi

19 August 2017

cites work

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Design of angiotensin converting enzyme inhibitors

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Antibiotics: where did we go wrong?

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Natural product-based anti-HIV drug discovery and development facilitated by the NCI developmental therapeutics program

21 January 2018

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Cycling antibiotics may not be good for your health

21 January 2018

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The Microbial Rosetta Stone Database: a compilation of global and emerging infectious microorganisms and bioterrorist threat agents

21 January 2018

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The future challenges facing the development of new antimicrobial drugs.

21 January 2018

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Case studies in current drug development: 'glycylcyclines'.

21 January 2018

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Development of daptomycin for gram-positive infections

21 January 2018

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21 January 2018

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Lipopeptides, focusing on daptomycin, for the treatment of Gram-positive infections

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Daptomycin - a novel antibiotic against Gram-positive pathogens

21 January 2018

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Overcoming antimicrobial resistance: profile of a new ketolide antibacterial, telithromycin

21 January 2018

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Biosynthesis and molecular genetics of clavulanic acid

21 January 2018

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Invasive aspergillosis in organ transplant recipients: new issues in epidemiologic characteristics, diagnosis, and management

21 January 2018

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Invasive fungal infections: a review of epidemiology and management options

21 January 2018

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Update on antifungals targeted to the cell wall: focus on beta-1,3-glucan synthase inhibitors

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2008.16

Role of micafungin in the antifungal armamentarium

21 January 2018

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Posaconazole: a new broad-spectrum antifungal agent

21 January 2018

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Signal-transduction cascades as targets for therapeutic intervention by natural products

21 January 2018

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Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis

21 January 2018

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The combinatorial chemistry of nature

21 January 2018

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Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity

21 January 2018

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Mitomycin dimers: polyfunctional cross-linkers of DNA.

21 January 2018

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GLUT2 in pancreatic islets: crucial target molecule in diabetes induced with multiple low doses of streptozotocin in mice

21 January 2018

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Cleavage behavior of calicheamicin gamma 1 and calicheamicin T

21 January 2018

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Natural products as sources of new drugs over the last 25 years

21 January 2018

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Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.16

Epothilones: mechanism of action and biologic activity

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2008.16

Curing metastatic testicular cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2008.16

Medical treatment of advanced testicular cancer.

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2008.16

Enzyme inhibitors of marine microbial origin with pharmaceutical importance

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2008.16

Effect of a purified amylase inhibitor on carbohydrate metabolism after a mixed meal in healthy humans

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2008.16

Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.16

Progress towards the discovery of xanthine oxidase inhibitors.

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2008.16

Rapamycin, an mTOR inhibitor, disrupts triglyceride metabolism in guinea pigs.

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2008.16

Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2008.16

Everolimus for the prevention of allograft rejection and vasculopathy in cardiac-transplant recipients

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2008.16

Targeting mTOR signaling for cancer therapy

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2008.16

Therapeutic targets: MTOR and related pathways

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2008.16

FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.16

Use of tacrolimus, a potent antifibrotic agent, in bleomycin-induced lung fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.16

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2008.16

Evaluation and development of spinosyns to control ectoparasites on cattle and sheep

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2008.16

Engineered biosynthesis of novel spinosyns bearing altered deoxyhexose substituents

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2008.16

Butenyl-spinosyns, a natural example of genetic engineering of antibiotic biosynthetic genes

21 January 2018

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Biosynthetic gene cluster of the herbicide phosphinothricin tripeptide from Streptomyces viridochromogenes Tü494.

21 January 2018

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avr-15 encodes a chloride channel subunit that mediates inhibitory glutamatergic neurotransmission and ivermectin sensitivity in Caenorhabditis elegans

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2008.16

Doramectin--a potent novel endectocide.

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2008.16

Comparison of ivermectin, doramectin, selamectin, and eleven intermediates in a nematode larval development assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.16

The determination of 5 anticoccidial drugs (nicarbazin, lasalocid, monensin, salinomycin and narasin) in animal livers and eggs by liquid chromatography linked with tandem mass spectrometry (LC-MS-MS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.16

Antibiotics as growth promotants: mode of action.

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2008.16

Antibiotic development pipeline runs dry. New drugs to fight resistant organisms are not being developed, experts say.

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2008.16

The future of anti-infective products in animal health

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2008.16

The European ban on growth-promoting antibiotics and emerging consequences for human and animal health

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2008.16

Erythromycin as a gastrointestinal prokinetic agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.16

History of the development of azole derivatives

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2008.16

Isolating "uncultivable" microorganisms in pure culture in a simulated natural environment

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2008.16

Fulfilling the promise of biotechnology

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2008.16

New antibiotics from bacterial natural products

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.16

Statins, High-Density Lipoprotein Cholesterol, and Regression of Coronary Atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.16

Fungal Enzyme Inhibitors as Pharmaceuticals, Toxins and Scourge of PCR

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.16

Caspofungin acetate: an antifungal agent

21 January 2018

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12 December 2020

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12 December 2020

Medicinal plants in therapy

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12 December 2020

Efficacy of Ivermectin against Strongyloides Stercoralis in Humans

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12 December 2020

Where have all the antibiotic patents gone?

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12 December 2020

Problems with antimicrobial resistance in gram-positive cocci

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12 December 2020

Improved production of pentostatin and identification of fermentation cometabolites

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12 December 2020

Pentostatin in T-non-Hodgkin's lymphomas: efficacy and effect on CD26+ T lymphocytes

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12 December 2020

Medicinals for the millennia: the historical record

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12 December 2020

GLUT2 in pancreatic islets: crucial target molecule in diabetes induced with multiple low doses of streptozotocin in mice

1 reference

12 December 2020

Refining the optimal chemotherapy regimen for good-risk metastatic nonseminomatous germ-cell tumors: a randomized trial of the Genito-Urinary Group of the French Federation of Cancer Centers (GETUG T93BP)

1 reference

12 December 2020

History of the discovery of cyclosporin and of its early pharmacological development.

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12 December 2020

Correlation of rejection episodes with FK 506 dosage, FK 506 level, and steroids following primary orthotopic liver transplant

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12 December 2020

Gastrointestinal and metabolic effects of amylase inhibition in diabetics

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12 December 2020

Inhibitors of HIV-1 replication [corrected; erratum to be published] that inhibit HIV integrase

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12 December 2020

Approval summary: gemtuzumab ozogamicin in relapsed acute myeloid leukemia

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12 December 2020

[Metabolic products of microorganisms. 98. Phosphinothricin and phosphinothricyl-alanyl-analine]

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12 December 2020

Clinical trial: effect of mitemcinal (a motilin agonist) on gastric emptying in patients with gastroparesis - a randomized, multicentre, placebo-controlled study

1 reference

12 December 2020

Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin

1 reference

12 December 2020

Milbemycins, a new family of macrolide antibiotics. Structure determination of milbemycins D, E, F, G, H, J and K.

2 references

12 December 2020

https://api.crossref.org/works/10.1038%2FJA.2008.16

7 January 2021

Actinomyces antibioticus, a New Soil Organism Antagonistic to Pathogenic and Non-pathogenic Bacteria

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12 December 2020

Bioactive metabolites of EM574 and EM523, erythromycin derivatives having strong gastrointestinal motor stimulating activity

1 reference

12 December 2020

Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties

1 reference

12 December 2020

A two component-type cytochrome P-450 monooxygenase system in a prokaryote that catalyzes hydroxylation of ML-236B to pravastatin, a tissue-selective inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase

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12 December 2020

Recent developments in tetracycline antibiotics

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12 December 2020

Production and Purification of Statins from Pleurotus ostreatus (Basidiomycetes) Strains

2 references

12 December 2020

https://api.crossref.org/works/10.1038%2FJA.2008.16

7 January 2021

Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action.

1 reference

12 December 2020

The public health threat of emerging viral disease

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12 December 2020

Anticancer drug discovery and development throughout the world.

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12 December 2020

New antibiotics, bleomycin A and B

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12 December 2020

The need for new antibiotics

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12 December 2020

Cancer statistics, 2007

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12 December 2020

Polyether Antibiotics: Versatile Carboxylic Acid Ionophores Produced by Streptomyces

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12 December 2020

Antifungal resistance trends towards the year 2000. Implications for therapy and new approaches

1 reference

12 December 2020

Identification of Two Genes from Streptomyces argillaceus Encoding Glycosyltransferases Involved in Transfer of a Disaccharide during Biosynthesis of the Antitumor Drug Mithramycin

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.16

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Weed Control for the Preservation of Biological Diversity

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7 January 2021

Identifiers

DOI

10.1038/JA.2008.16

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19 August 2017

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