Inhibition of mitochondrial pyruvate transport by zaprinast causes massive accumulation of aspartate at the expense of glutamate in the retina (Q37388865)

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English	Inhibition of mitochondrial pyruvate transport by zaprinast causes massive accumulation of aspartate at the expense of glutamate in the retina	scientific article

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29 February 2020

Inhibition of mitochondrial pyruvate transport by zaprinast causes massive accumulation of aspartate at the expense of glutamate in the retina (English)

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29 February 2020

Laura Contreras

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29 February 2020

Jorgina Satrustegui Gil Delgado

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29 February 2020

François Paquet-Durand

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29 February 2020

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Jianhai Du

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29 February 2020

Whitney M Cleghorn

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29 February 2020

Ken Lindsay

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29 February 2020

Austin M Rountree

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29 February 2020

Andrei O Chertov

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29 February 2020

Sally J Turner

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29 February 2020

Ayse Sahaboglu

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29 February 2020

Jonathan Linton

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29 February 2020

Martin Sadilek

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29 February 2020

Ian R Sweet

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29 February 2020

James B Hurley

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29 February 2020

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1 November 2013

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29 February 2020

Journal of Biological Chemistry

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29 February 2020

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29 February 2020

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29 February 2020

36129-36140

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29 February 2020

Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins

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6 September 2017

Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier.

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6 September 2017

A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans

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6 September 2017

Identification and functional expression of the mitochondrial pyruvate carrier

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Roles of glucose in photoreceptor survival

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PARP1 gene knock-out increases resistance to retinal degeneration without affecting retinal function.

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A homologous genetic basis of the murine cpfl1 mutant and human achromatopsia linked to mutations in the PDE6C gene

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Cyclic nucleotide-gated channels

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6 September 2017

Inhibition of N-type calcium channels by activation of GPR35, an orphan receptor, heterologously expressed in rat sympathetic neurons

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6 September 2017

Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35.

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6 September 2017

Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35

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6 September 2017

Excessive activation of cyclic nucleotide-gated channels contributes to neuronal degeneration of photoreceptors

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Efficacy and selectivity of phosphodiesterase-targeted drugs in inhibiting photoreceptor phosphodiesterase (PDE6) in retinal photoreceptors.

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6 September 2017

Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1

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6 September 2017

Impaired mitochondrial pyruvate importation in a patient and a fetus at risk

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6 September 2017

Identification of the mitochondrial glutamate transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms

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6 September 2017

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6 September 2017

Phosphodiesterase 5 inhibitors and nitrergic transmission-from zaprinast to sildenafil

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6 September 2017

Mutation spectrum of the gene encoding the beta subunit of rod phosphodiesterase among patients with autosomal recessive retinitis pigmentosa

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Autosomal recessive retinitis pigmentosa caused by mutations in the alpha subunit of rod cGMP phosphodiesterase

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Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase

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6 September 2017

The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors

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14 September 2017

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28 September 2017

Brain glutamine synthesis requires neuronal-born aspartate as amino donor for glial glutamate formation.

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based on heuristic

inferred from PubMed ID database lookup

Potential roles of conserved amino acids in the catalytic domain of the cGMP-binding cGMP-specific phosphodiesterase

1 reference

https://pubmed.ncbi.nlm.nih.gov/24187136

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tricarboxylic acid cycle in rat brain synaptosomes. Fluxes and interactions with aspartate aminotransferase and malate/aspartate shuttle

1 reference

https://pubmed.ncbi.nlm.nih.gov/24187136

12 December 2020

based on heuristic

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Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/24187136

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based on heuristic

inferred from PubMed ID database lookup

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10.1074/JBC.M113.507285

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29 February 2020

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29 February 2020

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29 February 2020

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