Mutation of Pro-258 in transmembrane domain 6 constitutively activates the G protein-coupled alpha-factor receptor. (Q37542040)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8692892%20AND%20SRC:MED&resulttype=core&format=json

17 October 2019

title

Mutation of Pro-258 in transmembrane domain 6 constitutively activates the G protein-coupled alpha-factor receptor (English)

1 reference

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G protein-coupled receptor

17 October 2019

main subject

0 references

transmembrane protein

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author

James B Konopka

series ordinal

1

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17 October 2019

author name string

S M Margarit

series ordinal

2

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17 October 2019

P Dube

series ordinal

3

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17 October 2019

language of work or name

English

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publication date

1 June 1996

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17 October 2019

number of pages

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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17 October 2019

volume

93

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17 October 2019

issue

13

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17 October 2019

page(s)

6764-6769

1 reference

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Nucleotide sequences of STE2 and STE3, cell type-specific sterile genes from Saccharomyces cerevisiae

17 October 2019

cites work

1 reference

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Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function.

23 August 2017

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AFR1 acts in conjunction with the alpha-factor receptor to promote morphogenesis and adaptation

23 August 2017

1 reference

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Identification of a novel sequence mediating regulated endocytosis of the G protein-coupled alpha-pheromone receptor in yeast

23 August 2017

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Mutations that alter the third cytoplasmic loop of the a-factor receptor lead to a constitutive and hypersensitive phenotype

23 August 2017

1 reference

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A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model

23 August 2017

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Direct evidence for ligand-induced internalization of the yeast alpha-factor pheromone receptor

23 August 2017

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MAP kinase pathways in yeast: for mating and more

23 August 2017

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AFR1 promotes polarized apical morphogenesis in Saccharomyces cerevisiae

23 August 2017

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A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia

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A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty

23 August 2017

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Mutants of Saccharomyces cerevisiae unresponsive to cell division control by polypeptide mating hormone

23 August 2017

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Binding of α-factor pheromone to yeast a cells: Chemical and genetic evidence for an α-factor receptor

23 August 2017

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Comparison of dose-response curves for alpha factor-induced cell division arrest, agglutination, and projection formation of yeast cells. Implication for the mechanism of alpha factor action

23 August 2017

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Two genes required for cell fusion during yeast conjugation: evidence for a pheromone-induced surface protein

23 August 2017

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New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites

23 August 2017

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Binding of alpha-factor pheromone to Saccharomyces cerevisiae a cells: dissociation constant and number of binding sites

23 August 2017

1 reference

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The yeast alpha-factor receptor: structural properties deduced from the sequence of the STE2 gene

23 August 2017

1 reference

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Beta and gamma subunits of a yeast guanine nucleotide-binding protein are not essential for membrane association of the alpha subunit but are required for receptor coupling

23 August 2017

1 reference

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Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2.

23 August 2017

1 reference

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In vivo topological analysis of Ste2, a yeast plasma membrane protein, by using beta-lactamase gene fusions

23 August 2017

1 reference

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Getting started with yeast

23 August 2017

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Model systems for the study of seven-transmembrane-segment receptors

23 August 2017

1 reference

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23 August 2017

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Constitutively active mutants of rhodopsin

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39101

Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation

23 August 2017

1 reference

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Substitutions in the hydrophobic core of the alpha-factor receptor of Saccharomyces cerevisiae permit response to Saccharomyces kluyveri alpha-factor and to antagonist

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39101

Pheromone response in yeast

23 August 2017

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Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas

23 August 2017

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Noncontiguous domains of the alpha-factor receptor of yeasts confer ligand specificity.

6 September 2017

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This is not a G protein-coupled receptor.

6 September 2017

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Regulation of the G-protein-coupled alpha-factor pheromone receptor by phosphorylation

6 September 2017

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The probable arrangement of the helices in G protein-coupled receptors.

14 September 2017

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Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

28 September 2017

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Constitutively active mutants of the alpha 2-adrenergic receptor

28 September 2017

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The third cytoplasmic loop of a yeast G-protein-coupled receptor controls pathway activation, ligand discrimination, and receptor internalization

25 June 2018

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Systematic mutagenesis of the yeast mating pheromone receptor third intracellular loop.

25 June 2018

1 reference

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Numbers of Receptor Sites from Scatchard Graphs: Facts and Fantasies

25 June 2018

1 reference

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The carboxy-terminal segment of the yeast alpha-factor receptor is a regulatory domain

25 June 2018

1 reference

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Proline kinks in transmembrane alpha-helices

25 June 2018

1 reference

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Specific activation of Gs by synthetic peptides corresponding to an intracellular loop of the beta-adrenergic receptor

25 June 2018

1 reference

12 December 2020

Signal transduction by a 5-HT2 receptor: a mechanistic hypothesis from molecular dynamics simulations of the three-dimensional model of the receptor complexed to ligands

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12 December 2020

Identification of a Gs activator region of the β2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation

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12 December 2020

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The C-terminus of the S. cerevisiae alpha-pheromone receptor mediates an adaptive response to pheromone

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Turned on to ill effect

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12 December 2020

Identifiers

DOI

10.1073/PNAS.93.13.6764

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8692892%20AND%20SRC:MED&resulttype=core&format=json

17 October 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8692892%20AND%20SRC:MED&resulttype=core&format=json

17 October 2019

PubMed publication ID

8692892

1 reference