Targeting mitochondrial dysfunction in neurodegenerative disease: Part I. (Q37698597)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20184395%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

review article

1 reference

title

Targeting mitochondrial dysfunction in neurodegenerative disease: Part I (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20184395%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

1 reference

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20184395%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Andrey Y. Abramov

series ordinal

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20184395%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

2

Sonia Gandhi

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20184395%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1

Victoria S Burchell

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20184395%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

author name string

Emma Deas

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20184395%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Hélène Plun-Favreau

series ordinal

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20184395%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

language of work or name

English

0 references

publication date

1 April 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20184395%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Therapeutic Targets

18 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20184395%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

volume

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20184395%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20184395%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

page(s)

369-385

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20184395%20AND%20SRC:MED&resulttype=core&format=json

How to live long and prosper: autophagy, mitochondria, and aging

18 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Redox analysis of human plasma allows separation of pro-oxidant events of aging from decline in antioxidant defenses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Mitochondrial protein import and human health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Age-dependent impairment of mitochondrial function in primate brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Mitochondrial polarisation status and [Ca2+]i signalling in rat cerebellar granule neurones aged in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

The mitochondrial permeability transition mediates both necrotic and apoptotic death of hepatocytes exposed to Br-A23187.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Oxidatively modified proteins in aging and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Mitochondria, oxidants, and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

The pathogenesis of Friedreich ataxia and the structure and function of frataxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Oxidative stress in Alzheimer's disease brain: new insights from redox proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Effects of 4-OH-2,3-trans-nonenal on human erythrocyte plasma membrane Ca2+ pump and passive Ca2+ permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Oxidative stress and mitochondrial dysfunction in neurodegeneration; cardiolipin a critical target?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Effect of oxidative DNA damage in promoter elements on transcription factor binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Decreases in mouse brain NAD+ and ATP induced by 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP): prevention by the poly(ADP-ribose) polymerase inhibitor, benzamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Cybrids in Alzheimer's disease: a cellular model of the disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Mitochondria in cybrids containing mtDNA from persons with mitochondriopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Free radicals and antioxidants in normal physiological functions and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Caenorhabditits elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Effects of overexpression of huntingtin proteins on mitochondrial integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Mutant huntingtin activates Nrf2-responsive genes and impairs dopamine synthesis in a PC12 model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Reduced membrane lipids in the cortex of Alzheimer's disease transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Mitochondrial approaches for neuroprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q(10) in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

A controlled trial of idebenone in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Safety and efficacy of idebenone versus tacrine in patients with Alzheimer's disease: results of a randomized, double-blind, parallel-group multicenter study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Idebenone treatment fails to slow cognitive decline in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Clinical experience with high-dose idebenone in Friedreich ataxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

NADPH oxidase as a therapeutic target in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Comparative pharmacological study of free radical scavenger, nitric oxide synthase inhibitor, nitric oxide synthase activator and cyclooxygenase inhibitor against MPTP neurotoxicity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

A double-blind, delayed-start trial of rasagiline in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Treating neurodegeneration by modifying mitochondria: potential solutions to a "complex" problem

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Multisystem manifestations of mitochondrial disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Implication of dopamine transporter system on 1-methyl-4-phenylpyridinium and rotenone effect in striatal synaptosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Dopaminergic toxicity of rotenone and the 1-methyl-4-phenylpyridinium ion after their stereotaxic administration to rats: implication for the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Systemic administration of rotenone produces selective damage in the striatum and globus pallidus, but not in the substantia nigra

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Mitochondrial involvement in Parkinson's disease, Huntington's disease, hereditary spastic paraplegia and Friedreich's ataxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Mitochondrial hexokinase II promotes neuronal survival and acts downstream of glycogen synthase kinase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Functional imaging of cerebral blood flow and glucose metabolism in Parkinson's disease and Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Reduced Activities of Thiamine-Dependent Enzymes in the Brains and Peripheral Tissues of Patients With Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

The expression of creatine kinase isoenzymes in neocortex of patients with neurodegenerative disorders: Alzheimer's and Pick's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

A new approach to treating Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Creatine supplementation in Parkinson disease: a placebo-controlled randomized pilot trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Creatine supplementation in Huntington's disease: a placebo-controlled pilot trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Altered regulation of the PINK1 locus: a link between type 2 diabetes and neurodegeneration?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

PPAR-gamma-mediated neuroprotection in a chronic mouse model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Targeting PGC-1 alpha to control energy homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Glutamate neurotoxicity and diseases of the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Calcium homeostasis, selective vulnerability and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Glutamate-induced deregulation of calcium homeostasis and mitochondrial dysfunction in mammalian central neurones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Glutamate receptors: RNA editing and death of motor neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Edited GluR2, a gatekeeper for motor neurone survival?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Impairment of mitochondrial calcium handling in a mtSOD1 cell culture model of motoneuron disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Hyperactive intracellular calcium signaling associated with localized mitochondrial defects in skeletal muscle of an animal model of amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Calcium signaling in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Memantine in patients with Parkinson's disease dementia or dementia with Lewy bodies: a double-blind, placebo-controlled, multicentre trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

A promising new treatment for Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

'Rejuvenation' protects neurons in mouse models of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Nordihydroguaiaretic acid increases glutamate uptake in vitro and in vivo: therapeutic implications for amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Specific reduction of calcium-binding protein (28-kilodalton calbindin-D) gene expression in aging and neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Combination therapy using minocycline and coenzyme Q10 in R6/2 transgenic Huntington's disease mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

PGC-1alpha, a new therapeutic target in Huntington's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

PINK1 function in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

De novo CoA biosynthesis is required to maintain DNA integrity during development of the Drosophila nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

Mitochondrial localization of human PANK2 and hypotheses of secondary iron accumulation in pantothenate kinase-associated neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

ALS, SOD and peroxynitrite

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652489

10.1517/14728221003652489

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20184395%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference