Obesity, hyperinsulinemia and breast cancer: novel targets and a novel role for metformin. (Q37750871)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20465505%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

review article

1 reference

title

Obesity, hyperinsulinemia and breast cancer: novel targets and a novel role for metformin (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20465505%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

0 references

1 reference

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20465505%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Bogna Wierusz-Wysocka

series ordinal

2

object named as

Bogna Wierusz-Wysocka

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20465505%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

publication date

1 May 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20465505%20AND%20SRC:MED&resulttype=core&format=json

Expert Review of Molecular Diagnostics: new diagnostic technologies are set to revolutionise healthcare

2 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20465505%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20465505%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20465505%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

page(s)

509-519

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20465505%20AND%20SRC:MED&resulttype=core&format=json

Body mass index as a prognostic feature in operable breast cancer: the International Breast Cancer Study Group experience

2 February 2020

cites work

1 reference

Premorbid body weight and its relations to primary tumour diameter in breast cancer patients; its dependence on estrogen and progesteron receptor status

21 January 2018

1 reference

Adult weight gain and histopathologic characteristics of breast cancer among postmenopausal women

21 January 2018

1 reference

Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults

21 January 2018

1 reference

Effect of obesity and other lifestyle factors on mortality in women with breast cancer.

21 January 2018

1 reference

Source of Estrogen Production in Postmenopausal Women1

21 January 2018

1 reference

The role of cytokines in regulating estrogen synthesis: implications for the etiology of breast cancer

21 January 2018

1 reference

Endogenous estrogen and postmenopausal breast cancer: a quantitative review

21 January 2018

1 reference

Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies

21 January 2018

1 reference

Postmenopausal serum androgens, oestrogens and breast cancer risk: the European prospective investigation into cancer and nutrition

21 January 2018

1 reference

Endogenous estrogen, androgen, and progesterone concentrations and breast cancer risk among postmenopausal women

21 January 2018

1 reference

Fasting insulin and outcome in early-stage breast cancer: results of a prospective cohort study.

21 January 2018

1 reference

Type 2 diabetes and subsequent incidence of breast cancer in the Nurses' Health Study

21 January 2018

1 reference

Estrogen receptor regulates insulin-like growth factor-I receptor gene expression in breast tumor cells: involvement of transcription factor Sp1.

21 January 2018

1 reference

Insulin-like growth factor-I controls BRCA1 gene expression through activation of transcription factor Sp1.

21 January 2018

1 reference

Elevated insulin-like growth factor-I receptor (IGF-IR) levels in primary breast tumors associated with BRCA1 mutations

21 January 2018

1 reference

Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease.

21 January 2018

1 reference

Insulin receptor expression by human prostate cancers

21 January 2018

1 reference

Phosphorylated insulin-like growth factor-i/insulin receptor is present in all breast cancer subtypes and is related to poor survival.

21 January 2018

1 reference

Hormone responsive human breast cancer in long-term tissue culture: effect of insulin

21 January 2018

1 reference

Insulin and insulin-like growth factor signalling in neoplasia

21 January 2018

1 reference

M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity

21 January 2018

1 reference

IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis

21 January 2018

1 reference

Presence of somatomedin receptors on primary human breast and colon carcinomas

21 January 2018

1 reference

Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor

21 January 2018

1 reference

Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871.

21 January 2018

1 reference

Growth inhibition of human prostate cancer cells in human adult bone implanted into nonobese diabetic/severe combined immunodeficient mice by a ligand-specific antibody to human insulin-like growth factors

21 January 2018

1 reference

In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417.

21 January 2018

1 reference

Insulin-like growth factor-I, IGF-binding protein-3, and mammographic breast density.

21 January 2018

1 reference

Crosstalk between IGF1R and estrogen receptor signaling in breast cancer.

21 January 2018

1 reference

Interaction between estrogen receptor alpha and insulin/IGF signaling in breast cancer

21 January 2018

1 reference

Regulation of breast cancer cell motility by insulin receptor substrate-2 (IRS-2) in metastatic variants of human breast cancer cell lines

21 January 2018

1 reference

Insulin receptor substrate-1 expression is regulated by estrogen in the MCF-7 human breast cancer cell line

21 January 2018

1 reference

Targeting the IGF1 axis in cancer proliferation

21 January 2018

1 reference

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

1 reference

The IRS-signalling system: a network of docking proteins that mediate insulin action

21 January 2018

1 reference

PKB/AKT: functional insights from genetic models

21 January 2018

1 reference

The Akt kinases: isoform specificity in metabolism and cancer

21 January 2018

1 reference

Akt activation by growth factors is a multiple-step process: the role of the PH domain

21 January 2018

1 reference

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

21 January 2018

1 reference

Oncogenic kinase signalling

21 January 2018

1 reference

TOR, a central controller of cell growth

21 January 2018

1 reference

TOR signalling and control of cell growth

21 January 2018

1 reference

Current development of mTOR inhibitors as anticancer agents

21 January 2018

1 reference

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

21 January 2018

1 reference

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

1 reference

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 January 2018

1 reference

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

1 reference

An expanding role for mTOR in cancer

21 January 2018

1 reference

The expanding TOR signaling network

21 January 2018

1 reference

Mammalian target of rapamycin inhibition as a therapeutic strategy in the management of urologic malignancies

21 January 2018

1 reference

Dysregulation of the TSC-mTOR pathway in human disease

21 January 2018

1 reference

United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling

21 January 2018

1 reference

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

21 January 2018

1 reference

Eukaryotic Translation Initiation Factor 4E Regulates Expression of Cyclin D1 at Transcriptional and Post-transcriptional Levels

21 January 2018

1 reference

Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E.

21 January 2018

1 reference

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

21 January 2018

1 reference

Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2.

21 January 2018

1 reference

Intracellular signal transduction pathway proteins as targets for cancer therapy.

21 January 2018

1 reference

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

21 January 2018

1 reference

Hypoxia prevents etoposide-induced DNA damage in cancer cells through a mechanism involving hypoxia-inducible factor 1.

21 January 2018

1 reference

Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase

21 January 2018

1 reference

Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity.

21 January 2018

1 reference

Insulin-like growth factor-I inhibits progesterone receptor expression in breast cancer cells via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway: progesterone receptor as a potential indicator of growth factor activity i

21 January 2018

1 reference

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

21 January 2018

1 reference

Role of the insulin-like growth factor family in cancer development and progression

21 January 2018

1 reference

Concurrent and sequential administration of chemotherapy and the Mammalian target of rapamycin inhibitor temsirolimus in human cancer cells and xenografts

21 January 2018

1 reference

Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer

21 January 2018

1 reference

Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer

21 January 2018

1 reference

Adiponectin: a link between obesity and cancer

21 January 2018

1 reference

Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity

21 January 2018

1 reference

Adiponectin and breast cancer risk

21 January 2018

1 reference

Adiponectin deficiency limits tumor vascularization in the MMTV-PyV-mT mouse model of mammary cancer

21 January 2018

1 reference

Proangiogenic contribution of adiponectin toward mammary tumor growth in vivo

21 January 2018

1 reference

Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans

21 January 2018

1 reference

Signal transduction by the JNK group of MAP kinases

21 January 2018

1 reference

A central role for JNK in obesity and insulin resistance

21 January 2018

1 reference

STAT3 as a central mediator of neoplastic cellular transformation

21 January 2018

1 reference

Nuclear factor-kappaB p65 inhibits mitogen-activated protein kinase signaling pathway in radioresistant breast cancer cells

21 January 2018

1 reference

Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway

21 January 2018

1 reference

AMPK phosphorylation of raptor mediates a metabolic checkpoint

21 January 2018

1 reference

Energy-dependent regulation of cell structure by AMP-activated protein kinase

21 January 2018

1 reference

LKB1 and AMPK maintain epithelial cell polarity under energetic stress

21 January 2018

1 reference

Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

21 January 2018

1 reference

Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin

21 January 2018

1 reference

Metformin and reduced risk of cancer in diabetic patients

21 January 2018

1 reference

New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes

21 January 2018

1 reference

Metformin associated with lower cancer mortality in type 2 diabetes: ZODIAC-16

21 January 2018

1 reference

Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer

21 January 2018

1 reference

The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells

21 January 2018

1 reference

Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo.

21 January 2018

1 reference

Insulin-lowering effects of metformin in women with early breast cancer

21 January 2018

1 reference

Metformin induces unique biological and molecular responses in triple negative breast cancer cells

21 January 2018

1 reference

Epidemiology of basal-like breast cancer

21 January 2018

1 reference

Differences in risk factors for breast cancer molecular subtypes in a population-based study

21 January 2018

1 reference

Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells

21 January 2018

1 reference

Lipid rafts: bringing order to chaos

21 January 2018

1 reference

Targeting fatty acid synthase-driven lipid rafts: a novel strategy to overcome trastuzumab resistance in breast cancer cells.

21 January 2018

1 reference

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.

21 January 2018

1 reference

ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome

21 January 2018

1 reference

Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission

21 January 2018

1 reference

mTOR in renal cell cancer: modulator of tumor biology and therapeutic target.

21 January 2018

1 reference

Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERalpha negative MDA-MB-435 breast cancer model

21 January 2018

1 reference

Further evidence to support the melanocytic origin of MDA-MB-435

21 January 2018

1 reference

Reduction of the individual cancer risk by physical exercise

21 January 2018

1 reference

The antidiabetic drug metformin: a pharmaceutical AMPK activator to overcome breast cancer resistance to HER2 inhibitors while decreasing risk of cardiomyopathy

21 January 2018

1 reference

Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth

21 January 2018

1 reference

LKB1 and mammalian target of rapamycin as predictive factors for the anticancer efficacy of metformin

21 January 2018

1 reference

Body Mass Index and Mortality among Older Breast Cancer Survivors in the Study of Osteoporotic Fractures

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1586/ERM.10.22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20465505%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1 reference