Proteases in cutaneous malignant melanoma: relevance as biomarker and therapeutic target. (Q37777976)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20686912%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

review article

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title

Proteases in cutaneous malignant melanoma: relevance as biomarker and therapeutic target (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20686912%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

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1

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9 February 2020

author name string

Eleonore Fröhlich

series ordinal

1

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23 August 2017

publication date

5 August 2010

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20686912%20AND%20SRC:MED&resulttype=core&format=json

Cellular and Molecular Life Sciences

9 February 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20686912%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

volume

67

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9 February 2020

issue

23

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9 February 2020

page(s)

3947-3960

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20686912%20AND%20SRC:MED&resulttype=core&format=json

The role of matrix metalloproteinases in stromal/epithelial interactions in the gut.

9 February 2020

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Late stage inhibition of hematogenous melanoma metastasis by cystatin C over-expression

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12 December 2020

Cathepsin L increases invasion and migration of B16 melanoma

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12 December 2020

The expression of proteolytic enzymes at the dermal invading front of primary cutaneous melanoma predicts metastasis

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12 December 2020

Antibodies to PAI-1 alter the invasive and migratory properties of human tumour cells in vitro

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12 December 2020

Expression and prognostic significance of Cathepsin L in early cutaneous malignant melanoma

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12 December 2020

Tumor-associated urokinase-type plasminogen activator: biological and clinical significance

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12 December 2020

Melanoma, nevogenesis, and stem cell biology

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12 December 2020

Decreased metastatic spread in mice homozygous for a null allele of the cystatin C protease inhibitor gene

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12 December 2020

Differential expression of the CD10 antigen (neutral endopeptidase) in primary versus metastatic malignant melanomas of the skin

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12 December 2020

Serum matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 in patients with malignant melanoma

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12 December 2020

Matrix metalloproteinases in human melanoma

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12 December 2020

Expression of matrix metalloproteinase-26 in multiple human cancer tissues and smooth muscle cells

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12 December 2020

Activation mechanisms of matrix metalloproteinases.

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12 December 2020

Identification of cells initiating human melanomas

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12 December 2020

Stromal Expression of MMP-13 Is Required for Melanoma Invasion and Metastasis

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12 December 2020

Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials

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12 December 2020

Lack of plasminogen activator inhibitor-1 effect in a transgenic mouse model of metastatic melanoma

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12 December 2020

Dipeptidylpeptidase IV activities are elevated in prostate cancers and adjacent benign hyperplastic glands

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12 December 2020

Granzymes in cancer and immunity

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12 December 2020

Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma

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12 December 2020

Extracellular proteases as targets for drug development

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12 December 2020

Immunocytochemical and immunoelectron microscopic demonstration of cathepsin B in human malignant melanoma

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12 December 2020

Intratumoral gene delivery of anti-cathepsin L single-chain variable fragment by lentiviral vector inhibits tumor progression induced by human melanoma cells.

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12 December 2020

Spitz naevi may express components of the plasminogen activation system

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12 December 2020

Prognostic value of MMP-2 immunoreactive protein (72 kD type IV collagenase) in primary skin melanoma

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12 December 2020

Tissue- and urokinase-type plasminogen activators and type 1 plasminogen activator inhibitor in melanomas and benign skin pigment neoplasms.

1 reference

12 December 2020

Downregulation of matrix metalloprotease-9 and urokinase plasminogen activator by TX-1877 results in decreased tumor growth and metastasis on xenograft model of rectal cancer

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12 December 2020

Cysteine protease inhibitors isolated from human malignant melanoma tissue

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12 December 2020

ADAMs: focus on the protease domain

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12 December 2020

Cysteine cathepsins in human cancer

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12 December 2020

Cathepsin E prevents tumor growth and metastasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface

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12 December 2020

Inactive cathepsin B-like enzyme in human melanoma culture medium

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12 December 2020

The urokinase plasminogen activator system: a target for anti-cancer therapy.

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12 December 2020

Clinical relevance of cathepsin B-like enzyme activity and cysteine proteinase inhibitor in melanocytic tumours

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12 December 2020

Expression of gelatinase B and the extracellular matrix metalloproteinase inducer EMMPRIN in benign and malignant pigment cell lesions of the skin

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12 December 2020

The changing prognosis of melanoma

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12 December 2020

Decreased immunoreactive maspin expression in intermediate thickness and thick primary melanoma lesions

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12 December 2020

Expression of cathepsin D in primary and metastatic human melanoma and dysplastic nevi

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12 December 2020

Activity, expression, and transcription rate of the cathepsins B, D, H, and L in cutaneous malignant melanoma

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12 December 2020

Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma

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12 December 2020

Matrix metalloproteinases in tumour invasion and metastasis

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12 December 2020

The active fraction of plasmatic plasminogen activator inhibitor type 1 as a possible indicator of increased risk for metastatic melanoma

1 reference

12 December 2020

Phase II study of marimastat (BB-2516) in malignant melanoma: a clinical and tumor biopsy study of the National Cancer Institute of Canada Clinical Trials Group

1 reference

12 December 2020

Tumour endoproteases: the cutting edge of cancer drug delivery?

1 reference

12 December 2020

Matrix Metalloproteinase-9 (MMP-9) polymorphisms in patients with cutaneous malignant melanoma

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12 December 2020

Tissue inhibitors of metalloproteinases in cell signaling: metalloproteinase-independent biological activities.

1 reference

12 December 2020

Tissue biomarkers for prognosis in cutaneous melanoma: a systematic review and meta-analysis

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12 December 2020

Modulation of the malignant phenotype with the urokinase-type plasminogen activator and the type I plasminogen activator inhibitor

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12 December 2020

Global perspectives of contemporary epidemiological trends of cutaneous malignant melanoma

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12 December 2020

The collagenolytic activity of cathepsin K is unique among mammalian proteinases

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12 December 2020

Loss of maspin expression contributes to a more invasive potential in malignant melanoma

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12 December 2020

Expression of matrix metalloproteinases in the microenvironment of spontaneous and experimental melanoma metastases reflects the requirements for tumor formation

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12 December 2020

Hypoxia-mediated stimulation of carcinoma cell invasiveness via upregulation of urokinase receptor expression

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12 December 2020

Unexpected role of plasminogen activator inhibitor 1 in cell adhesion and detachment.

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12 December 2020

Dipeptidyl peptidase IV (DPPIV) inhibits cellular invasion of melanoma cells.

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12 December 2020

Molecular aspects of tumor cell invasion and metastasis

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12 December 2020

Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: part 2. In vivo distribution and tumor localization studies

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12 December 2020

Cathepsin B: association with plasma membrane in metastatic tumors

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12 December 2020

Dipeptidyl peptidase IV expression in endometrial endometrioid adenocarcinoma and its inverse correlation with tumor grade

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12 December 2020

Characterization of the cathepsin B gene and multiple mRNAs in human tissues: evidence for alternative splicing of cathepsin B pre-mRNA.

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12 December 2020

Inhibitory effect of Boerhaavia diffusa on experimental metastasis by B16F10 melanoma in C57BL/6 mice.

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12 December 2020

Invasive properties of murine squamous carcinoma cells: secretion of matrix-degrading cathepsins is attributable to a deficiency in the mannose 6-phosphate/insulin-like growth factor II receptor.

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12 December 2020

Imaging proteolysis by living human breast cancer cells

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12 December 2020

A study of tumor progression: the precursor lesions of superficial spreading and nodular melanoma

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12 December 2020

Effect of cysteine proteinase inhibitors on murine B16 melanoma cell invasion in vitro

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12 December 2020

The epidemiology of skin cancer

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12 December 2020

Regulation of cell adhesion by PAI-1.

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12 December 2020

Prolonged survival and decreased invasive activity attributable to dipeptidyl peptidase IV overexpression in ovarian carcinoma.

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12 December 2020

Pericellular pH affects distribution and secretion of cathepsin B in malignant cells

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12 December 2020

Avoiding spam in the proteolytic internet: future strategies for anti-metastatic MMP inhibition.

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12 December 2020

Hypoxia influences vasculogenic mimicry channel formation and tumor invasion-related protein expression in melanoma

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12 December 2020

The 92-kDa gelatinase B is expressed by advanced stage melanoma cells: suppression by somatic cell hybridization with early stage melanoma cells

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12 December 2020

Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion

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12 December 2020

High expression levels of collagenase-1 and stromelysin-1 correlate with shorter disease-free survival in human metastatic melanoma

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12 December 2020

Serum matrix metalloproteinase-8 is associated with ulceration and vascular invasion of malignant melanoma.

1 reference

12 December 2020

Collagenase-3 (MMP-13) expression in cutaneous malignant melanoma

1 reference

12 December 2020

Self-assembled nanoparticles of hydrophobically-modified polysaccharide bearing vitamin H as a targeted anti-cancer drug delivery system

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12 December 2020

The distribution of secondary growths in cancer of the breast. 1889

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12 December 2020

Modulation of metastatic potential by cell surface urokinase of murine melanoma cells

1 reference

12 December 2020

Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth.

1 reference

12 December 2020

Plasminogen activators, their inhibitors, and urokinase receptor emerge in late stages of melanocytic tumor progression

1 reference

12 December 2020

A prostate-specific antigen-activated channel-forming toxin as therapy for prostatic disease

1 reference

12 December 2020

Inhibition of tumorigenicity and metastasis of human melanoma cells by anti-cathepsin L single chain variable fragment

1 reference

12 December 2020

Stromelysin-3 is a potent negative regulator of adipogenesis participating to cancer cell-adipocyte interaction/crosstalk at the tumor invasive front

1 reference

12 December 2020

Pericellular mobilization of the tissue-destructive cysteine proteinases, cathepsins B, L, and S, by human monocyte-derived macrophages

1 reference

12 December 2020

Urokinase-type plasminogen activator and plasminogen activator inhibitor type 1 and type 2 in stage I malignant melanoma

1 reference

12 December 2020

Different roles for plasminogen activators and metalloproteinases in melanoma metastasis.

1 reference

12 December 2020

Novel biomarkers in malignant melanoma

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12 December 2020

Stromal expression of c-Ets1 transcription factor correlates with tumor invasion

1 reference

12 December 2020

Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature

1 reference

12 December 2020

Evolving role of uPA/uPAR system in human cancers

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12 December 2020

Cathepsin-D affects multiple tumor progression steps in vivo: proliferation, angiogenesis and apoptosis

1 reference

12 December 2020

Cell surface activation of progelatinase A (proMMP-2) and cell migration

1 reference

12 December 2020

Cathepsins B, H, and L and their inhibitors stefin A and cystatin C in sera of melanoma patients

1 reference

12 December 2020

CD26 (dipeptidyl peptidase IV/DPP IV) as a novel molecular marker for differentiated thyroid carcinoma

1 reference

12 December 2020

Matrix metalloproteinases in tumor progression: focus on basal and squamous cell skin cancer.

1 reference

12 December 2020

A possible role for cysteine proteinase and its inhibitors in motility of malignant melanoma and other tumour cells

1 reference

12 December 2020

Cathepsin A activity in primary and metastatic human melanocytic tumors

1 reference

12 December 2020

TIMP-3 deficiency in the host, but not in the tumor, enhances tumor growth and angiogenesis

1 reference

12 December 2020

Plasminogen activation in melanocytic neoplasia

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12 December 2020

TIMP-2 growth-stimulatory activity: a concentration- and cell type-specific response in the presence of insulin

1 reference

12 December 2020

Membrane associated proteases and their inhibitors in tumour angiogenesis

1 reference

12 December 2020

Matrix metalloproteinase-2 (72 kD type IV collagenase) expression occurs in the early stage of human melanocytic tumour progression and may have prognostic value

1 reference

12 December 2020

Expression of CD26/dipeptidyl-peptidase IV in benign and malignant pigment-cell lesions of the skin

1 reference

12 December 2020

Melanoma incidence and mortality in Scotland 1979-2003.

1 reference

12 December 2020

Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization.

1 reference

12 December 2020

Maspin expression, angiogenesis, prognostic parameters, and outcome in malignant melanoma.

1 reference

12 December 2020

Hypoxia suppresses the production of matrix metalloproteinases and the migration of human monocyte-derived dendritic cells

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12 December 2020

Pericellular proteases in angiogenesis and vasculogenesis

1 reference

12 December 2020

Expression of collagenases-1 and -3 and their inhibitors TIMP-1 and -3 correlates with the level of invasion in malignant melanomas

1 reference

12 December 2020

Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model.

1 reference

12 December 2020

Membrane-associated cathepsin L: a role in metastasis of melanomas

1 reference

12 December 2020

HER2 breast cancer therapies: a review

1 reference

12 December 2020

An intracellular form of cathepsin B contributes to invasiveness in cancer.

1 reference

12 December 2020

Matrix metalloproteinase inhibitors as anticancer agents

1 reference

12 December 2020

Poly(L-histidine)-PEG block copolymer micelles and pH-induced destabilization

1 reference

12 December 2020

Cathepsin K in melanoma invasion.

1 reference

12 December 2020

Malignant melanoma: clinical variants and prognostic indicators

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12 December 2020

Macrophage elastase (matrix metalloproteinase-12) suppresses growth of lung metastases

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12 December 2020

MMP-21 is upregulated at early stages of melanoma progression but disappears with more aggressive phenotype

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12 December 2020

Expression and activation of matrix metalloproteinase-2 (MMP-2) and its co-localization with membrane-type 1 matrix metalloproteinase (MT1-MMP) correlate with melanoma progression

1 reference

12 December 2020

Plasminogen activators, tissue degradation, and cancer

1 reference

12 December 2020

Mixture of trypsin, chymotrypsin and papain reduces formation of metastases and extends survival time of C57Bl6 mice with syngeneic melanoma B16.

1 reference

12 December 2020

Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies.

1 reference

12 December 2020

Antimetastatic and antitumor effect of a recombinant human tissue inhibitor of metalloproteinases-2 in murine melanoma models

1 reference

12 December 2020

Dipeptidyl peptidase II is not a marker for progression in melanoma.

1 reference

12 December 2020

Cancer invasion and tissue remodeling--cooperation of protease systems and cell types.

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12 December 2020

Urokinase receptor antagonists inhibit angiogenesis and primary tumor growth in syngeneic mice

1 reference

12 December 2020

Tumoral and macrophage uPAR and MMP-9 contribute to the invasiveness of B16 murine melanoma cells.

1 reference

12 December 2020

Expression of matrilysin (matrix metalloproteinase-7) in primary cutaneous and metastatic melanoma

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12 December 2020

Gelatinase A activity directly modulates melanoma cell adhesion and spreading.

1 reference

12 December 2020

Increased activity of cathepsin B in fibroblasts isolated from primary melanoma in comparison to fibroblasts from normal skin

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12 December 2020

Tumor cell membrane cathepsin B.

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12 December 2020

Human leukocyte elastase counteracts matrix metalloproteinase-7 induced apoptosis resistance of tumor cells

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12 December 2020

Adam-9 expression and regulation in human skin melanoma and melanoma cell lines

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12 December 2020

Lysosomal cathepsin B: correlation with metastatic potential

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12 December 2020

Stroma -- regulator of cancer cell progression

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12 December 2020

Utility of adjuvant systemic therapy in melanoma.

1 reference

12 December 2020

10.1007/S00018-010-0469-5

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20686912%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

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