Dermatologic side effects associated with the MEK 1/2 inhibitor selumetinib (AZD6244, ARRY-142886). (Q37803366)

8 January 2018

title

Dermatologic side effects associated with the MEK 1/2 inhibitor selumetinib (AZD6244, ARRY-142886). (English)

1 reference

8 January 2018

main subject

selumetinib

1 reference

ChEBI release 2020-05-28

4

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8 January 2018

author name string

Yevgeniy Balagula

1

1 reference

8 January 2018

Katherine Barth Huston

2

1 reference

8 January 2018

Klaus J Busam

3

1 reference

8 January 2018

Paul B Chapman

5

1 reference

8 January 2018

Patricia L Myskowski

6

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8 January 2018

publication date

27 October 2010

1 reference

8 January 2018

Investigational New Drugs

published in

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8 January 2018

volume

29

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8 January 2018

issue

5

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8 January 2018

page(s)

1114-1121

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8 January 2018

Dermatologic infections in cancer patients treated with epidermal growth factor receptor inhibitor therapy

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Skin toxicities associated with epidermal growth factor receptor inhibitors

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Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers

23 June 2018

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AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in precl

23 June 2018

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Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor

23 June 2018

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Dermatologic side effects associated with the epidermal growth factor receptor inhibitors

23 June 2018

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Clinical signs, pathophysiology and management of skin toxicity during therapy with epidermal growth factor receptor inhibitors

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Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer

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The EGF receptor - an essential regulator of multiple epidermal functions

23 June 2018

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The mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor AZD6244 (ARRY-142886) induces growth arrest in melanoma cells and tumor regression when combined with docetaxel

23 June 2018

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Targeted inhibition of the extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) in the treatment of hepatocellular carcinoma.

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Phase I and pharmacodynamic study of the oral MEK inhibitor CI-1040 in patients with advanced malignancies

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Case studies showing clinical signs and management of cutaneous toxicity of the MEK1/2 inhibitor AZD6244 (ARRY-142886) in patients with solid tumours

1 September 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/20978926

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S10637-010-9567-3

1 reference

8 January 2018

PMC publication ID

5691597

1 reference

8 January 2018

PubMed publication ID

20978926

1 reference

8 January 2018