Therapeutically targeting the SUMOylation, Ubiquitination and Proteasome pathways as a novel anticancer strategy (Q37815035)

From Wikidata

Jump to navigation Jump to search

scientific article

edit

Language	Label	Description	Also known as
English	Therapeutically targeting the SUMOylation, Ubiquitination and Proteasome pathways as a novel anticancer strategy	scientific article

Statements

instance of

scholarly article

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21125340

retrieved

23 August 2017

review article

1 reference

stated in

Europe PubMed Central

title

Therapeutically targeting the SUMOylation, Ubiquitination and Proteasome pathways as a novel anticancer strategy (English)

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21125340

retrieved

23 August 2017

main subject

protein ubiquitination

1 reference

based on heuristic

inferred from title

protein sumoylation

1 reference

based on heuristic

inferred from title

author name string

James J Driscoll

series ordinal

1

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21125340

retrieved

23 August 2017

Roopa Dechowdhury

series ordinal

2

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21125340

retrieved

23 August 2017

publication date

27 November 2010

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21125340

retrieved

23 August 2017

published in

Targeted oncology

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21125340

retrieved

23 August 2017

volume

5

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21125340

retrieved

23 August 2017

issue

4

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21125340

retrieved

23 August 2017

page(s)

281-289

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21125340

retrieved

23 August 2017

cites work

The HECT family of E3 ubiquitin ligases: multiple players in cancer development

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1007%2FS11523-010-0165-2

retrieved

21 January 2018

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The proteasome: a proteolytic nanomachine of cell regulation and waste disposal

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The base of the proteasome regulatory particle exhibits chaperone-like activity

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Velcade: U.S. FDA approval for the treatment of multiple myeloma progressing on prior therapy

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MicroRNA-mediated regulation of Ubc9 expression in cancer cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The fast-growing business of SUMO chains

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SCF and Cullin/Ring H2-based ubiquitin ligases

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ubiquitin system

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Feeding the machine: mechanisms of proteasome-catalyzed degradation of ubiquitinated proteins

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutting edge: bortezomib-treated tumors sensitized to NK cell apoptosis paradoxically acquire resistance to antigen-specific T cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear and unclear functions of SUMO

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein modification by SUMO

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein degradation or regulation: Ub the judge

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Basic Medical Research Award. The ubiquitin system

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An additional role for SUMO in ubiquitin-mediated proteolysis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The proteasome (multicatalytic protease) is a component of the 1500-kDa proteolytic complex which degrades ubiquitin-conjugated proteins

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting Ubc9 for cancer therapy

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular sequelae of proteasome inhibition in human multiple myeloma cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A multicomponent system that degrades proteins conjugated to ubiquitin. Resolution of factors and evidence for ATP-dependent complex formation.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Themes and variations on ubiquitylation

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modification of proteins by ubiquitin and ubiquitin-like proteins

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Frequency, characteristics, and reversibility of peripheral neuropathy during treatment of advanced multiple myeloma with bortezomib

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of a gene encoding Rpn10 of the fission yeast proteasome reveals that the polyubiquitin-binding site of this subunit is essential when Rpn12/Mts3 activity is compromised.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A gated channel into the proteasome core particle

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin, proteasomes, and the regulation of intracellular protein degradation

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The yeast Hex3.Slx8 heterodimer is a ubiquitin ligase stimulated by substrate sumoylation

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin receptors and ERAD: a network of pathways to the proteasome

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The sumoylation pathway is dysregulated in multiple myeloma and is associated with adverse patient outcome

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin is degraded by the ubiquitin pathway

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The proteasome: paradigm of a self-compartmentalizing protease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of 20S proteasome from yeast at 2.4 A resolution

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electron microscopy and subunit-subunit interaction studies reveal a first architecture of COP9 signalosome

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteins interacting with the 26S proteasome

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteasome inhibitor bortezomib modulates TLR4-induced dendritic cell activation

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteasome inhibition: a novel approach to cancer therapy

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SCF-mediated protein degradation and cell cycle control

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment with proteasome inhibitor bortezomib enhances antigen-specific CD8+ T-cell-mediated antitumor immunity induced by DNA vaccination

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting the ubiquitin system in cancer therapy

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase 2 study of bortezomib in relapsed, refractory myeloma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin-dependent proteolytic control of SUMO conjugates

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catalytic activities of the 20 S proteasome, a multicatalytic proteinase complex

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple associated proteins regulate proteasome structure and function

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A 26 S protease subunit that binds ubiquitin conjugates

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antigen processing by the proteasome

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SUMO-targeted ubiquitin ligases in genome stability.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a 26S proteasome-associated UCH in fission yeast

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SUMO: ligases, isopeptidases and nuclear pores

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fission yeast Rnf4 homologs are required for DNA repair.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bortezomib or high-dose dexamethasone for relapsed multiple myeloma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SUMO: a regulator of gene expression and genome integrity.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell-mediated lysis of myeloma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mts4, a non-ATPase subunit of the 26 S protease in fission yeast is essential for mitosis and interacts directly with the ATPase subunit Mts2.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

26 S proteasomes function as stable entities

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The regulatory complex of Drosophila melanogaster 26S proteasomes. Subunit composition and localization of a deubiquitylating enzyme

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Killer cell inhibitory receptors for MHC class I molecules regulate lysis of melanoma cells mediated by NK cells, gamma delta T cells, and antigen-specific CTL.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21125340

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1007/S11523-010-0165-2

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21125340

retrieved

23 August 2017

PubMed publication ID

21125340

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21125340

retrieved

23 August 2017

 

Sitelinks

Wikipedia(0 entries)

edit

Wikibooks(0 entries)

edit

Wikinews(0 entries)

edit

Wikiquote(0 entries)

edit

Wikisource(0 entries)

edit

Wikiversity(0 entries)

edit

Wikivoyage(0 entries)

edit

Wiktionary(0 entries)

edit

Multilingual sites(0 entries)

edit

Retrieved from "https://www.wikidata.org/w/index.php?title=Q37815035&oldid=2200978251"