The DNA damage response: Balancing the scale between cancer and ageing (Q37824549)

23 August 2017

1 reference

14 July 2021

The DNA damage response: Balancing the scale between cancer and ageing (English)

1 reference

23 August 2017

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24 January 2021

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8 February 2021

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14 July 2021

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PubMed publication ID

21191148

author name string

Elena G Seviour

series ordinal

1

1 reference

23 August 2017

Shiaw-Yin Lin

series ordinal

2

1 reference

23 August 2017

language of work or name

1 reference

1 December 2010

5 references

23 August 2017

3 April 2019

24 January 2021

8 February 2021

14 July 2021

5 references

23 August 2017

3 April 2019

24 January 2021

8 February 2021

14 July 2021

2

1 reference

23 August 2017

12

1 reference

23 August 2017

900-907

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Creative Commons Attribution 2.5 Generic

23 August 2017

4 references

3 April 2019

24 January 2021

8 February 2021

on focus list of Wikimedia project

14 July 2021

ScienceSource

0 references

cites work

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Paradoxical suppression of cellular senescence by p53

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Multiple roles of BRIT1/MCPH1 in DNA damage response, DNA repair, and cancer suppression

6 September 2017

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Genomic instability--an evolving hallmark of cancer

6 September 2017

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BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control

6 September 2017

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Defective mismatch repair, microsatellite mutation bias, and variability in clinical cancer phenotypes

6 September 2017

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BRCA1 and its toolbox for the maintenance of genome integrity

6 September 2017

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Impaired DNA damage response--an Achilles' heel sensitizing cancer to chemotherapy and radiotherapy

6 September 2017

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Mouse models for ATR deficiency

6 September 2017

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Many roads lead to oncogene-induced senescence

6 September 2017

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The DNA damage response: ten years after

6 September 2017

1 reference

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Human CtIP promotes DNA end resection

6 September 2017

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DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosis

6 September 2017

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Soothing the watchman: telomerase reduces the p53-dependent cellular stress response

6 September 2017

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The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability

6 September 2017

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Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation

6 September 2017

1 reference

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Surviving the breakup: the DNA damage checkpoint.

6 September 2017

1 reference

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A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM

6 September 2017

1 reference

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ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

6 September 2017

1 reference

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Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

6 September 2017

1 reference

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Ataxia-telangiectasia, an evolving phenotype

6 September 2017

1 reference

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6 September 2017

The Chk2 protein kinase

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Initiating cellular stress responses

6 September 2017

1 reference

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BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

The serial cultivation of human diploid cell strains

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

Cancer and ageing: rival demons?

6 September 2017

1 reference

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Single-strand DNA gaps trigger an ATR- and Cdc7-dependent checkpoint

6 September 2017

1 reference

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Roles of BRCA1 in DNA damage repair: a link between development and cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

6 September 2017

1 reference

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Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform

6 September 2017

1 reference

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The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication

6 September 2017

1 reference

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Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

Interfaces between the detection, signaling, and repair of DNA damage

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

p53 mutant mice that display early ageing-associated phenotypes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

ATR and ATRIP: partners in checkpoint signaling

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

Genotoxic and non-genotoxic pathways of p53 induction

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

Functional decline in aging and disease: a role for apoptosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

Regulation of the G2/M transition by p53.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

ATM dependent apoptosis in the nervous system

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

Molecular cytogenetic analysis of breast cancer cell lines

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

Cell proliferation and apoptosis in the immune system in the elderly

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

BRCA1-associated growth arrest is RB-dependent

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

A role for ATR in the DNA damage-induced phosphorylation of p53

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

ATM associates with and phosphorylates p53: mapping the region of interaction

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

DNA damage induces phosphorylation of the amino terminus of p53

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

Instability and decay of the primary structure of DNA

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

The clonal evolution of tumor cell populations

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

Recombination and meiosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

BRIT1/MCPH1 links chromatin remodelling to DNA damage response.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

BRCA1 promotes induction of ssDNA by ionizing radiation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

Array-based comparative genomic hybridization identifies localized DNA amplifications and homozygous deletions in pancreatic cancer

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

The repair of ionising radiation-induced damage to DNA.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

TP53 and MTOR crosstalk to regulate cellular senescence

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

Molecular and biochemical pathways of apoptosis in lymphocytes from aged humans

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

Cell biology. Guiding ATM to broken DNA.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

Base excision repair and nucleotide excision repair contribute to the removal of N-methylpurines from active genes

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034178

The ATM-SMC1 pathway is essential for activation of the chromium[VI]-induced S-phase checkpoint

1 September 2018

1 reference

12 December 2020

Frequent loss of heterozygosity for loci on chromosome 8p in hepatocellular carcinoma, colorectal cancer, and lung cancer

1 reference

12 December 2020

Tumorigenesis as a consequence of genetic instability in Brca1 mutant mice

1 reference

12 December 2020

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

1 reference

12 December 2020

Chromosome 8p deletions and 8q gains are associated with tumor progression and poor prognosis in prostate cancer

1 reference

12 December 2020

Identifiers

DOI

10.18632/AGING.100248

0 references

1 reference

23 August 2017

PubMed publication ID

21191148

1 reference