Emerging biomedical applications of synthetic biology (Q37962354)

26 August 2017

title

Emerging biomedical applications of synthetic biology (English)

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26 August 2017

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2

Martin Fussenegger

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26 August 2017

1

Wilfried Weber

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26 August 2017

publication date

29 November 2011

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26 August 2017

published in

Nature Reviews Genetics

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26 August 2017

volume

13

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26 August 2017

issue

1

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26 August 2017

page(s)

21-35

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Network news: innovations in 21st century systems biology

26 August 2017

cites work

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Evolvability and hierarchy in rewired bacterial gene networks

21 January 2018

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Identification of functional elements and regulatory circuits by Drosophila modENCODE

21 January 2018

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Informing Biological Design by Integration of Systems and Synthetic Biology

21 January 2018

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Genotype and SNP calling from next-generation sequencing data

21 January 2018

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Scalable gene synthesis by selective amplification of DNA pools from high-fidelity microchips

21 January 2018

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High-fidelity gene synthesis by retrieval of sequence-verified DNA identified using high-throughput pyrosequencing

21 January 2018

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Parallel on-chip gene synthesis and application to optimization of protein expression.

21 January 2018

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Evidence for large diversity in the human transcriptome created by Alu RNA editing

21 January 2018

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Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy

21 January 2018

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Creation of a bacterial cell controlled by a chemically synthesized genome

21 January 2018

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Life after the synthetic cell

21 January 2018

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21 January 2018

Making cellular memories

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A synchronized quorum of genetic clocks

21 January 2018

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Diversity-based, model-guided construction of synthetic gene networks with predicted functions

21 January 2018

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A synthetic oscillatory network of transcriptional regulators

21 January 2018

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A synthetic gene-metabolic oscillator.

21 January 2018

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Construction of a genetic toggle switch in Escherichia coli

21 January 2018

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Hysteresis in a synthetic mammalian gene network

21 January 2018

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An engineered epigenetic transgene switch in mammalian cells

21 January 2018

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Rationally designed logic integration of regulatory signals in mammalian cells

21 January 2018

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A universal RNAi-based logic evaluator that operates in mammalian cells

21 January 2018

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A fast, robust and tunable synthetic gene oscillator.

21 January 2018

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Intron length increases oscillatory periods of gene expression in animal cells

21 January 2018

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A tunable synthetic mammalian oscillator

21 January 2018

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A synthetic-natural hybrid oscillator in human cells

21 January 2018

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A synthetic time-delay circuit in mammalian cells and mice

21 January 2018

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Multi-input RNAi-based logic circuit for identification of specific cancer cells

21 January 2018

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Synthetic biology: integrated gene circuits

21 January 2018

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Mammalian synthetic biology--from tools to therapies

21 January 2018

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Recent advances in mammalian synthetic biology-design of synthetic transgene control networks

21 January 2018

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Molecular diversity--the toolbox for synthetic gene switches and networks

21 January 2018

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RNA-based computation in live cells

21 January 2018

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Ligand-dependent regulatory RNA parts for Synthetic Biology in eukaryotes

21 January 2018

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Frameworks for programming biological function through RNA parts and devices

21 January 2018

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Refinement and standardization of synthetic biological parts and devices

21 January 2018

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Mammalian synthetic biology: engineering of sophisticated gene networks

21 January 2018

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Ultrasensitivity and noise propagation in a synthetic transcriptional cascade.

21 January 2018

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Semi-synthetic mammalian gene regulatory networks

21 January 2018

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Intronically encoded siRNAs improve dynamic range of mammalian gene regulation systems and toggle switch

21 January 2018

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Origin of bistability underlying mammalian cell cycle entry

21 January 2018

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Synthetic ecosystems based on airborne inter- and intrakingdom communication

21 January 2018

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Streptogramin-based gene regulation systems for mammalian cells

21 January 2018

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Controlling transgene expression in subcutaneous implants using a skin lotion containing the apple metabolite phloretin

21 January 2018

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De novo design and construction of an inducible gene expression system in mammalian cells

21 January 2018

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Development of genetic circuitry exhibiting toggle switch or oscillatory behavior in Escherichia coli

21 January 2018

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Multistability in the lactose utilization network of Escherichia coli

21 January 2018

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A genetic time-delay circuitry in mammalian cells

21 January 2018

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Engineered bidirectional communication mediates a consensus in a microbial biofilm consortium

21 January 2018

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Programmed population control by cell-cell communication and regulated killing.

21 January 2018

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A synthetic multicellular system for programmed pattern formation

21 January 2018

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Watch the clock-engineering biological systems to be on time

21 January 2018

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A synthetic low-frequency mammalian oscillator

21 January 2018

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Synthetic biology: exploring and exploiting genetic modularity through the design of novel biological networks

21 January 2018

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Eukaryotic systems broaden the scope of synthetic biology

21 January 2018

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Synthetic biology: applications come of age

21 January 2018

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Next-generation synthetic gene networks

21 January 2018

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The second wave of synthetic biology: from modules to systems

21 January 2018

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A designer network coordinating bovine artificial insemination by ovulation-triggered release of implanted sperms

21 January 2018

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Self-sufficient control of urate homeostasis in mice by a synthetic circuit

21 January 2018

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A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice

21 January 2018

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Synthetic biology moving into the clinic

21 January 2018

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Characterization of the reconstructed 1918 Spanish influenza pandemic virus

21 January 2018

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Complete chemical synthesis, assembly, and cloning of a Mycoplasma genitalium genome

21 January 2018

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A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission

21 January 2018

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Infectious diseases. As swine flu circles globe, scientists grapple with basic questions.

21 January 2018

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Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic

21 January 2018

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Synthetic viruses: a new opportunity to understand and prevent viral disease

21 January 2018

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Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice

21 January 2018

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Antibody-profiling technologies for studying humoral responses to infectious agents

21 January 2018

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Anti-Borrelia burgdorferi antibody profile in post-Lyme disease syndrome.

21 January 2018

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LIPS arrays for simultaneous detection of antibodies against partial and whole proteomes of HCV, HIV and EBV.

21 January 2018

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Mutations of the Igbeta gene cause agammaglobulinemia in man.

21 January 2018

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Oligomeric organization of the B-cell antigen receptor on resting cells

21 January 2018

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Autoantigen discovery with a synthetic human peptidome

21 January 2018

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A virus-like particle vaccine for epidemic Chikungunya virus protects nonhuman primates against infection

21 January 2018

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Virus attenuation by genome-scale changes in codon pair bias

21 January 2018

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Optimization and quantification of protein synthesis inside liposomes

21 January 2018

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Heat-stable oral alga-based vaccine protects mice from Staphylococcus aureus infection

21 January 2018

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Female-specific insect lethality engineered using alternative splicing.

21 January 2018

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Female-specific flightless phenotype for mosquito control

21 January 2018

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Genetic elimination of dengue vector mosquitoes.

21 January 2018

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A synthetic homing endonuclease-based gene drive system in the human malaria mosquito

21 January 2018

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Macrolide-based transgene control in mammalian cells and mice

21 January 2018

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The impact of synthetic biology on drug discovery

21 January 2018

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A synthetic mammalian gene circuit reveals antituberculosis compounds

21 January 2018

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Stringent rosiglitazone-dependent gene switch in muscle cells without effect on myogenic differentiation

21 January 2018

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A system for small-molecule control of conditionally replication-competent adenoviral vectors

21 January 2018

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Streptomyces-derived quorum-sensing systems engineered for adjustable transgene expression in mammalian cells and mice

21 January 2018

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Synthetic EthR inhibitors boost antituberculous activity of ethionamide

21 January 2018

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Controlled proliferation by multigene metabolic engineering enhances the productivity of Chinese hamster ovary cells

21 January 2018

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In vitro assays for anticancer drug discovery--a novel approach based on engineered mammalian cell lines

21 January 2018

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A novel mammalian cell-based approach for the discovery of anticancer drugs with reduced cytotoxicity on non-dividing cells

21 January 2018

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Drug discovery and natural products: end of an era or an endless frontier?

21 January 2018

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Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms

21 January 2018

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Chemical biology: Synthetic metabolism goes green

21 January 2018

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Silencing of tryptamine biosynthesis for production of nonnatural alkaloids in plant culture

21 January 2018

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Integrating carbon-halogen bond formation into medicinal plant metabolism.

21 January 2018

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Production of the antimalarial drug precursor artemisinic acid in engineered yeast

21 January 2018

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Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

21 January 2018

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Engineering Escherichia coli for production of functionalized terpenoids using plant P450s

21 January 2018

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The impact of mammalian gene regulation concepts on functional genomic research, metabolic engineering, and advanced gene therapies

21 January 2018

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Drug-sensing hydrogels for the inducible release of biopharmaceuticals

21 January 2018

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Genetically engineered protein in hydrogels tailors stimuli-responsive characteristics

21 January 2018

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A coumermycin/novobiocin-regulated gene expression system

21 January 2018

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Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum

21 January 2018

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Metabolite-enabled eradication of bacterial persisters by aminoglycosides

21 January 2018

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Bacterial charity work leads to population-wide resistance

21 January 2018

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Dispersing biofilms with engineered enzymatic bacteriophage

21 January 2018

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Sublethal antibiotic treatment leads to multidrug resistance via radical-induced mutagenesis

21 January 2018

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How antibiotics kill bacteria: from targets to networks

21 January 2018

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A common mechanism of cellular death induced by bactericidal antibiotics

21 January 2018

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Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapy

21 January 2018

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Fighting bacterial infections-future treatment options

21 January 2018

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Engineered bacterial communication prevents Vibrio cholerae virulence in an infant mouse model

21 January 2018

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Secretion of insulinotropic proteins by commensal bacteria: rewiring the gut to treat diabetes

21 January 2018

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Engineering the perfect (bacterial) cancer therapy

21 January 2018

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Environmentally controlled invasion of cancer cells by engineered bacteria

21 January 2018

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Genetically engineered Salmonella typhimurium as an imageable therapeutic probe for cancer

21 January 2018

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Tumour-targeted delivery of TRAIL using Salmonella typhimurium enhances breast cancer survival in mice.

21 January 2018

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In vivo gene regulation in Salmonella spp. by a salicylate-dependent control circuit

21 January 2018

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Short hairpin RNA-expressing bacteria elicit RNA interference in mammals

21 January 2018

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Reprogrammed viruses as cancer therapeutics: targeted, armed and shielded

21 January 2018

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Therapeutic protein transduction of mammalian cells and mice by nucleic acid-free lentiviral nanoparticles

21 January 2018

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Protein transduction from retroviral Gag precursors

21 January 2018

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Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription

21 January 2018

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Purification and characterization of 1-aminocyclopropane-1-carboxylate oxidase from apple fruit

21 January 2018

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Targeting cancer by transcriptional control in cancer gene therapy and viral oncolysis

21 January 2018

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Redirecting tyrosine kinase signaling to an apoptotic caspase pathway through chimeric adaptor proteins

21 January 2018

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How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?

21 January 2018

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A tunable dual-promoter integrator for targeting of cancer cells

21 January 2018

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Engineering ligand-responsive gene-control elements: lessons learned from natural riboswitches

21 January 2018

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Artificial ribozyme switches containing natural riboswitch aptamer domains

21 January 2018

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Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems

21 January 2018

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Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains.

21 January 2018

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The promise and potential pitfalls of chimeric antigen receptors

21 January 2018

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Reprogramming cellular behavior with RNA controllers responsive to endogenous proteins

21 January 2018

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Synthetic biology: engineering Escherichia coli to see light

21 January 2018

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Multichromatic control of gene expression in Escherichia coli

21 January 2018

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A synthetic genetic edge detection program.

21 January 2018

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Induction of protein-protein interactions in live cells using light

21 January 2018

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Spatiotemporal control of cell signalling using a light-switchable protein interaction.

21 January 2018

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HucR, a novel uric acid-responsive member of the MarR family of transcriptional regulators from Deinococcus radiodurans

21 January 2018

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A novel system for trigger-controlled drug release from polymer capsules

21 January 2018

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Design of high-throughput-compatible protocols for microencapsulation, cryopreservation and release of bovine spermatozoa.

21 January 2018

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Short-term BMP-2 expression is sufficient for in vivo osteochondral differentiation of mesenchymal stem cells

21 January 2018

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An autonomous system for identifying and governing a cell's state in yeast.

21 January 2018

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Genome-sequencing anniversary. A celebration of the genome, part I

21 January 2018

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Creating bacterial strains from genomes that have been cloned and engineered in yeast

31 March 2020

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The potential of synthetic biology: a view from the European Academies Science Advisory Council

31 March 2020

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From pond scum to pharmacy shelf

31 March 2020

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Synthetic mammalian gene networks as a blueprint for the design of interactive biohybrid materials

31 March 2020

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Science snipes at Oxitec transgenic-mosquito trial

31 March 2020

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12 December 2020

An engineered mammalian band-pass network

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12 December 2020

Design of a novel mammalian screening system for the detection of bioavailable, non-cytotoxic streptogramin antibiotics

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12 December 2020

Cloning and expression in Escherichia coli of the gene encoding Aspergillus flavus urate oxidase

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12 December 2020

Identifiers

DOI

10.1038/NRG3094

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26 August 2017

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