The BAFF/APRIL system: emerging functions beyond B cell biology and autoimmunity (Q38107660)

29 August 2017

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28 October 2022

The BAFF/APRIL system: emerging functions beyond B cell biology and autoimmunity (English)

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29 August 2017

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Fabien B Vincent

1

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29 August 2017

Damien Saulep-Easton

2

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29 August 2017

William A Figgett

3

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29 August 2017

Kirsten A Fairfax

4

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29 August 2017

Fabienne Mackay

5

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29 August 2017

language of work or name

English

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publication date

15 May 2013

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Cytokine and Growth Factor Reviews

29 August 2017

1 June 2013

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28 October 2022

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29 August 2017

28 October 2022

24

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29 August 2017

issue

3

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29 August 2017

page(s)

203-215

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B-cell activating factor of the tumour necrosis factor family expression in blood monocytes and T cells from patients with primary Sjögren's syndrome.

29 August 2017

cites work

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12 December 2020

APRIL secreted by neutrophils binds to heparan sulfate proteoglycans to create plasma cell niches in human mucosa

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12 December 2020

Expression and function of TNF family member B cell-activating factor in the development of autoimmune arthritis

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12 December 2020

Transmembrane activator and calcium-modulating cyclophilin ligand interactor mutations in common variable immunodeficiency: clinical and immunologic outcomes in heterozygotes

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12 December 2020

TACI:Fc scavenging B cell activating factor (BAFF) alleviates ovalbumin-induced bronchial asthma in mice

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12 December 2020

APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth

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12 December 2020

TNF superfamily member 13, APRIL, inhibits allergic lung inflammation

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12 December 2020

APRIL binding to BCMA activates a JNK2-FOXO3-GADD45 pathway and induces a G2/M cell growth arrest in liver cells.

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12 December 2020

TACI mutations and impaired B-cell function in subjects with CVID and healthy heterozygotes

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12 December 2020

Tonic B cell antigen receptor signals supply an NF-kappaB substrate for prosurvival BLyS signaling.

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12 December 2020

Elevated serum B-Lymphocyte activating factor (BAFF) in chronic hepatitis C virus infection: association with autoimmunity

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12 December 2020

BAFF/BLyS inhibitors: A new prospect for treatment of systemic lupus erythematosus.

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12 December 2020

Identification of proteoglycans as the APRIL-specific binding partners.

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12 December 2020

TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLyS

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12 December 2020

A BAFF-R mutation associated with non-Hodgkin lymphoma alters TRAF recruitment and reveals new insights into BAFF-R signaling.

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12 December 2020

The lack of epithelial interleukin-7 and BAFF/BLyS gene expression in prostate cancer as a possible mechanism of tumor escape from immunosurveillance

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12 December 2020

The C104R mutant impairs the function of transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) through haploinsufficiency

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12 December 2020

Expression of BAFF and BAFF-R in follicular lymphoma: correlation with clinicopathologic characteristics and survival outcomes

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12 December 2020

Functional implication of BAFF synthesis and release in gangliosides-stimulated microglia

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12 December 2020

Induction of B Cell-Activating Factor by Viral Infection Is a General Phenomenon, but the Types of Viruses and Mechanisms Depend on Cell Type

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12 December 2020

TACI deficiency impairs sustained Blimp-1 expression in B cells decreasing long-lived plasma cells in the bone marrow

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12 December 2020

Detection of the TNFSF members BAFF, APRIL, TWEAK and their receptors in normal kidney and renal cell carcinomas.

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12 December 2020

B cell-activating factor is a novel diagnosis parameter for asthma

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12 December 2020

Therapeutic effects of TACI-Ig on rat with adjuvant arthritis

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12 December 2020

Decreased expression of tumor necrosis factor family receptors involved in humoral immune responses in preterm neonates

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12 December 2020

Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID)

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12 December 2020

Rare mutations in TNFRSF13B increase the risk of asthma symptoms in Swedish children

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12 December 2020

B Cell and BAFF dependence of IFN-α-exaggerated disease in systemic lupus erythematosus-prone NZM 2328 mice

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12 December 2020

APRIL is overexpressed in cancer: link with tumor progression

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12 December 2020

Serum BAFF and APRIL might be associated with disease activity and kidney damage in patients with anti-glomerular basement membrane disease

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12 December 2020

Mutational Analysis of Human BAFF Receptor TNFRSF13C (BAFF-R) in Patients with Common Variable Immunodeficiency

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12 December 2020

Atacicept in patients with rheumatoid arthritis and an inadequate response to tumor necrosis factor antagonist therapy: results of a phase II, randomized, placebo-controlled, dose-finding trial

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12 December 2020

TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease

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12 December 2020

HIV-1 gp120 impairs the induction of B cell responses by TLR9-activated plasmacytoid dendritic cells

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12 December 2020

Intravenous immunoglobulin inhibits BAFF production in chronic inflammatory demyelinating polyneuropathy - a new mechanism of action?

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12 December 2020

B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia

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12 December 2020

B-cell-activating factor is a regulator of adipokines and a possible mediator between adipocytes and macrophages

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12 December 2020

Safety, pharmacokinetics and pharmacodynamics of atacicept in healthy volunteers

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12 December 2020

Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans.

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12 December 2020

Transmembrane activator, calcium modulator, and cyclophilin ligand interactor drives plasma cell differentiation in LPS-activated B cells.

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12 December 2020

Circulating B-cell activating factor level predicts clinical response of chronic graft-versus-host disease to extracorporeal photopheresis

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12 December 2020

BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth

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12 December 2020

BAFF and innate immunity: new therapeutic targets for systemic lupus erythematosus

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12 December 2020

Airway epithelial cells produce B cell-activating factor of TNF family by an IFN-beta-dependent mechanism

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12 December 2020

Increased levels of BAFF and APRIL related to human active pulmonary tuberculosis

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12 December 2020

Recovery of B-cell homeostasis after rituximab in chronic graft-versus-host disease

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12 December 2020

B cells from patients with chronic GVHD are activated and primed for survival via BAFF-mediated pathways

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12 December 2020

Selectivity of BAFF/BLyS and APRIL for binding to the TNF family receptors BAFFR/BR3 and BCMA.

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12 December 2020

Malaria infection alters the expression of B-cell activating factor resulting in diminished memory antibody responses and survival

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12 December 2020

B cell homeostasis and the development of chronic graft-versus-host disease: implications for B cell-depleting therapy

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12 December 2020

Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands

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12 December 2020

Significant differences in B-cell subpopulations characterize patients with chronic graft-versus-host disease–associated dysgammaglobulinemia

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12 December 2020

Atacicept in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a phase II, randomized, placebo-controlled trial

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12 December 2020

Identification of BLyS (B lymphocyte stimulator), a non-myelin-associated protein, as a functional ligand for Nogo-66 receptor.

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12 December 2020

BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma

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12 December 2020

Serum levels of BAFF and APRIL in myeloperoxidase anti-neutrophil cytoplasmic autoantibody-associated renal vasculitis: association with disease activity

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12 December 2020

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12 December 2020

Focus on systemic lupus erythematosus in indigenous Australians: towards a better understanding of autoimmune diseases

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12 December 2020

Increased B cell-activating factor (BAFF) level in the sputum of children with asthma.

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12 December 2020

Atacicept in patients with rheumatoid arthritis: results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating, single- and repeated-dose study

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12 December 2020

Serum BAFF expression in patients with myasthenia gravis.

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12 December 2020

The TNF family member APRIL dampens collagen-induced arthritis

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12 December 2020

Production of the plasma-cell survival factor a proliferation-inducing ligand (APRIL) peaks in myeloid precursor cells from human bone marrow.

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12 December 2020

TACI is mutant in common variable immunodeficiency and IgA deficiency

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12 December 2020

Nonclinical safety, pharmacokinetics, and pharmacodynamics of atacicept

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12 December 2020

TACI expression is low both in human and mouse newborns

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12 December 2020

Abnormal high expression of B-cell activating factor belonging to the TNF superfamily (BAFF) associated with long-term outcome in kidney transplant recipients

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12 December 2020

Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency

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12 December 2020

The plasma concentration of the B cell activating factor is increased in children with acute malaria

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12 December 2020

Phase 1b trial of atacicept, a recombinant protein binding BLyS and APRIL, in patients with chronic lymphocytic leukemia

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12 December 2020

Baff serum level predicts time to first treatment in early chronic lymphocytic leukemia.

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12 December 2020

The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88

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12 December 2020

Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor

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12 December 2020

Tabalumab in rheumatoid arthritis patients with an inadequate response to methotrexate and naive to biologic therapy: a phase II, randomized, placebo-controlled trial

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12 December 2020

Deficiency in TNFRSF13B (TACI) expands T-follicular helper and germinal center B cells via increased ICOS-ligand expression but impairs plasma cell survival

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12 December 2020

Tabalumab, an anti-BAFF monoclonal antibody, in patients with active rheumatoid arthritis with an inadequate response to TNF inhibitors.

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12 December 2020

Genetic and molecular functional characterization of variants within TNFSF13B, a positional candidate preeclampsia susceptibility gene on 13q

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12 December 2020

Overexpression of B cell-activating factor (BAFF) in neutrophils of oral cavity cancer patients - preliminary study.

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12 December 2020

Regulation of the T-independent humoral response by TACI

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12 December 2020

Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial

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12 December 2020

BAFF and APRIL as osteoclast-derived survival factors for myeloma cells: a rationale for TACI-Fc treatment in patients with multiple myeloma

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12 December 2020

Endothelial cells elicit immune-enhancing responses to dengue virus infection

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12 December 2020

Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase

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12 December 2020

Therapeutic effects of TACI-Ig on collagen-induced arthritis by regulating T and B lymphocytes function in DBA/1 mice

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12 December 2020

Effect of interleukin-2 on synthesis of B cell activating factor belonging to the tumor necrosis factor family (BAFF) in human peripheral blood mononuclear cells.

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12 December 2020

Mutation of the BAFF furin cleavage site impairs B-cell homeostasis and antibody responses.

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12 December 2020

Perspectives on common variable immune deficiency

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12 December 2020

BAFF augments certain Th1-associated inflammatory responses.

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12 December 2020

Murine BAFF expression is up-regulated by estrogen and interferons: implications for sex bias in the development of autoimmunity

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12 December 2020

BAFF-R promotes cell proliferation and survival through interaction with IKKbeta and NF-kappaB/c-Rel in the nucleus of normal and neoplastic B-lymphoid cells

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12 December 2020

Atacicept in combination with MMF and corticosteroids in lupus nephritis: results of a prematurely terminated trial.

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12 December 2020

BCMA is essential for the survival of long-lived bone marrow plasma cells

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12 December 2020

APRIL and BAFF proteins increase proliferation of human adipose-derived stem cells through activation of Erk1/2 MAP kinase

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12 December 2020

Role of TNFRSF13B variants in patients with common variable immunodeficiency

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12 December 2020

Mechanism of action of transmembrane activator and calcium modulator ligand interactor-Ig in murine systemic lupus erythematosus

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12 December 2020

Natural Immunity to HIV: a delicate balance between strength and control

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12 December 2020

CD19(+)CD21(low) B cells and patients at risk for NIH-defined chronic graft-versus-host disease with bronchiolitis obliterans syndrome.

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12 December 2020

An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein

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12 December 2020

APRIL (TNFSF13) regulates collagen-induced arthritis, IL-17 production and Th2 response

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12 December 2020

Signaling pathways for B cell-activating factor (BAFF) and a proliferation-inducing ligand (APRIL) in human placenta

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12 December 2020

Serum BAFF levels are related to angiogenesis and prognosis in patients with multiple myeloma

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12 December 2020

A novel compound heterozygous TACI mutation in an autosomal recessive common variable immunodeficiency (CVID) family

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12 December 2020

Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis

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12 December 2020

Reduced B lymphocyte and immunoglobulin levels after atacicept treatment in patients with systemic lupus erythematosus: results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating trial

1 reference

12 December 2020

Antidrug antibodies (ADAb) to tumour necrosis factor (TNF)-specific neutralising agents in chronic inflammatory diseases: a real issue, a clinical perspective

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12 December 2020

Innate immune signals modulate antiviral and polyreactive antibody responses during severe respiratory syncytial virus infection

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12 December 2020

Genetic variation in recipient B-cell activating factor modulates phenotype of GVHD.

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12 December 2020

BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone

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12 December 2020

The structure of the TNFRSF13C promoter enables differential expression of BAFF-R during B cell ontogeny and terminal differentiation.

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12 December 2020

deltaBAFF, a splice isoform of BAFF, opposes full-length BAFF activity in vivo in transgenic mouse models

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12 December 2020

B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency syndrome in humans.

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12 December 2020

Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL.

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12 December 2020

A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus

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12 December 2020

Blockade of B-cell-activating factor suppresses lupus-like syndrome in autoimmune BXSB mice.

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12 December 2020

APRIL and TACI interact with syndecan-1 on the surface of multiple myeloma cells to form an essential survival loop.

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12 December 2020

Systemic activation of the immune system induces aberrant BAFF and APRIL expression in B cells in patients with systemic lupus erythematosus

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12 December 2020

TACI-Ig prevents the development of airway hyperresponsiveness in a murine model of asthma

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12 December 2020

EBV-Encoded Latent Membrane Protein 1 Cooperates with BAFF/BLyS and APRIL to Induce T Cell-Independent Ig Heavy Chain Class Switching

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12 December 2020

Stromal endothelial cells establish a bidirectional crosstalk with chronic lymphocytic leukemia cells through the TNF-related factors BAFF, APRIL, and CD40L.

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12 December 2020

BAFF and MyD88 signals promote a lupuslike disease independent of T cells

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12 December 2020

Effect of long-term belimumab treatment on B cells in systemic lupus erythematosus: extension of a phase II, double-blind, placebo-controlled, dose-ranging study

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12 December 2020

Local release of B cell-activating factor of the TNF family after segmental allergen challenge of allergic subjects

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12 December 2020

Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations

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12 December 2020

TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts

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12 December 2020

B cell-activating factor controls the production of adipokines and induces insulin resistance

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12 December 2020

The C76R transmembrane activator and calcium modulator cyclophilin ligand interactor mutation disrupts antibody production and B-cell homeostasis in heterozygous and homozygous mice

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12 December 2020

B-cell maturation antigen (BCMA) activation exerts specific proinflammatory effects in normal human keratinocytes and is preferentially expressed in inflammatory skin pathologies

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12 December 2020

Respiratory syncytial virus infection of airway epithelial cells, in vivo and in vitro, supports pulmonary antibody responses by inducing expression of the B cell differentiation factor BAFF.

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12 December 2020

Stimulation of the primary anti-HIV antibody response by IFN-alpha in patients with acute HIV-1 infection

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12 December 2020

Variability in the biological response to anti-CD20 B cell depletion in systemic lupus erythaematosus

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12 December 2020

Serum BAFF concentrations in patients with Graves' disease and orbitopathy before and after immunosuppressive therapy.

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12 December 2020

Induction of BAFF expression by IFN-γ via JAK/STAT signaling pathways in human intestinal epithelial cells.

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12 December 2020

BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells

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12 December 2020

B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells

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12 December 2020

An exploratory dose-escalating study investigating the safety, tolerability, pharmacokinetics and pharmacodynamics of intravenous atacicept in patients with systemic lupus erythematosus

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12 December 2020

SCF and IL-31 rather than IL-17 and BAFF are potential indicators in patients with allergic asthma

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12 December 2020

Protective antiviral antibody responses in a mouse model of influenza virus infection require TACI

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12 December 2020

Activation and accumulation of B cells in TACI-deficient mice

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12 December 2020

Aberrant expression of functional BAFF-system receptors by malignant B-cell precursors impacts leukemia cell survival

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12 December 2020

Adipocytes as immune cells: differential expression of TWEAK, BAFF, and APRIL and their receptors (Fn14, BAFF-R, TACI, and BCMA) at different stages of normal and pathological adipose tissue development

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12 December 2020

Treatment of acute lymphoblastic leukemia with an rGel/BLyS fusion toxin

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12 December 2020

Altered B-cell homeostasis and excess BAFF in human chronic graft-versus-host disease

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12 December 2020

Synthesis and release of B-lymphocyte stimulator from myeloid cells

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12 December 2020

Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps

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12 December 2020

The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature

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12 December 2020

Mcl-1 is essential for the survival of plasma cells

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12 December 2020

Selective killing of Burkitt's lymphoma cells by mBAFF-targeted delivery of PinX1

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12 December 2020

Molecular cloning and functional characterization of murine transmembrane activator and CAML interactor (TACI) with chromosomal localization in human and mouse

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12 December 2020

Plasma levels of B-lymphocyte stimulator increase with HIV disease progression

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12 December 2020

Formation of virus-like clusters is an intrinsic property of the tumor necrosis factor family member BAFF (B cell activating factor).

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12 December 2020

10.1016/J.CYTOGFR.2013.04.003

Identifiers

DOI

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29 August 2017

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