Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia (Q38287713)

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English	Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

1 September 2017

Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia (English)

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PubMed publication ID

1 September 2017

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author name string

Masakazu Higuchi

1

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1 September 2017

Darin O'Brien

2

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1 September 2017

Parasakthy Kumaravelu

3

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Europe PubMed Central

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1 September 2017

Noel Lenny

4

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1 September 2017

Eng-Juh Yeoh

5

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1 September 2017

James R Downing

6

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1 September 2017

publication date

1 February 2002

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Europe PubMed Central

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1 September 2017

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Europe PubMed Central

PubMed publication ID

1 September 2017

1

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Europe PubMed Central

PubMed publication ID

1 September 2017

1

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1 September 2017

63-74

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1 September 2017

Myeloblastoma with an 8;21 chromosome translocation in acute myeloblastic leukemia

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Associations between morphology, karyotype, and clinical features in myeloid leukemias.

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7 January 2021

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Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse.

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Dichotomy of AML1-ETO functions: growth arrest versus block of differentiation

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The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia

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The AML1-ETO chimaeric transcription factor in acute myeloid leukaemia: biology and clinical significance

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Alterations of the AML1 transcription factor in human leukemia

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Clinical heterogeneity in acute myelogenous leukemia with the 8;21 translocation.

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Block of granulocytic differentiation of 32Dcl3 cells by AML1/ETO(MTG8) but not by highly expressed Bcl-2.

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7 January 2021

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Inducible gene targeting in mice

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Targeted oncogene activation by site-specific recombination in transgenic mice

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Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia

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AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation

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Granulocytic sarcoma: a clinicopathologic study of 61 biopsied cases

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Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha

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AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

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Differential effects of p19(Arf) and p16(Ink4a) loss on senescence of murine bone marrow-derived preB cells and macrophages

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Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta

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Expression of AML1/MTG8 transcripts in clonogenic cells grown from bone marrow of patients in remission of acute myeloid leukaemia with t(8;21)

1 reference

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The INK4a/ARF network in tumour suppression

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7 January 2021

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Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

1 reference

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8;21 translocation in acute granulocytic leukaemia: cytological, cytochemical and clinical features

1 reference

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7 January 2021

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Estrogen-dependent E2a/Pbx1 myeloid cell lines exhibit conditional differentiation that can be arrested by other leukemic oncoproteins

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Granulocytic sarcoma is associated with the 8;21 translocation in acute myeloid leukemia

1 reference

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7 January 2021

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Granulocytic sarcoma (chloroma). Presentation of an unusual case

1 reference

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Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor

1 reference

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Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

1 reference

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The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo

1 reference

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7 January 2021

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Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

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AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

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7 January 2021

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10.1016/S1535-6108(02)00016-8

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Europe PubMed Central

PubMed publication ID

1 September 2017

release_s64vet6xjjcd3f5ywmdhraun64

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24 November 2022

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 September 2017

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