Targeting perlecan in human keratinocytes reveals novel roles for perlecan in epidermal formation (Q38319148)

2 September 2017

title

Targeting perlecan in human keratinocytes reveals novel roles for perlecan in epidermal formation (English)

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2 September 2017

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10

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2 September 2017

11

Reuven Bergman

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2 September 2017

Ifat Sher

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2 September 2017

Simona Zisman-Rozen

2

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2 September 2017

Liat Eliahu

3

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2 September 2017

John M Whitelock

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2 September 2017

Nicole Maas-Szabowski

5

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2 September 2017

Yoshihiko Yamada

6

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2 September 2017

Dirk Breitkreutz

7

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2 September 2017

Norbert E Fusenig

8

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2 September 2017

Eri Arikawa-Hirasawa

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2 September 2017

Dina Ron

12

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2 September 2017

language of work or name

English

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publication date

2 November 2005

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Journal of Biological Chemistry

2 September 2017

published in

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2 September 2017

volume

281

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2 September 2017

issue

8

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2 September 2017

page(s)

5178-5187

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Supramolecular assembly of basement membranes

2 September 2017

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Life without perlecan has its problems

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The C-terminal domain V of perlecan promotes beta1 integrin-mediated cell adhesion, binds heparin, nidogen and fibulin-2 and can be modified by glycosaminoglycans

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Perlecan maintains the integrity of cartilage and some basement membranes

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Perlecan is essential for cartilage and cephalic development

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Dyssegmental dysplasia, Silverman-Handmaker type, is caused by functional null mutations of the perlecan gene.

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The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7

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Organotypic keratinocyte cocultures in defined medium with regular epidermal morphogenesis and differentiation

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Comparison of gene expression profiles in human keratinocyte mono-layer cultures, reconstituted epidermis and normal human skin; transcriptional effects of retinoid treatments in reconstituted human epidermis

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Carcinogenesis in mouse and human cells: parallels and paradoxes

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Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation

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Epidermis generated in vitro: practical considerations and applications

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Mutual induction of growth factor gene expression by epidermal-dermal cell interaction

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Science, medicine and the future: healing chronic wounds

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Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells

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Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line

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Perlecan is required to inhibit thrombosis after deep vascular injury and contributes to endothelial cell-mediated inhibition of intimal hyperplasia

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Vitamin D enhances mitogenesis mediated by keratinocyte growth factor receptor in keratinocytes

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21 January 2018

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Human perlecan immunopurified from different endothelial cell sources has different adhesive properties for vascular cells.

21 January 2018

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The Ki-67 protein: from the known and the unknown

21 January 2018

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Epidermal tissue regeneration and stromal interaction in HaCaT cells is initiated by TGF-alpha

21 January 2018

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Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo

21 January 2018

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Suppression of autocrine and paracrine functions of basic fibroblast growth factor by stable expression of perlecan antisense cDNA

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21 January 2018

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Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound

21 January 2018

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21 January 2018

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Heparan sulfate chains of perlecan are indispensable in the lens capsule but not in the kidney

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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A role for the perlecan protein core in the activation of the keratinocyte growth factor receptor

21 January 2018

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The N-terminal globular domain of the laminin alpha1 chain binds to alpha1beta1 and alpha2beta1 integrins and to the heparan sulfate-containing domains of perlecan

21 January 2018

1 reference

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Epidermal differentiation and basement membrane formation by HaCaT cells in surface transplants

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M509500200

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2 September 2017

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