Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT. (Q38319485)

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English	Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT.	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

2 September 2017

Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT. (English)

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Europe PubMed Central

PubMed publication ID

2 September 2017

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apoptotic process

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based on heuristic

inferred from title

Teresita M. Bellido

3

object named as

Teresita Bellido

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Europe PubMed Central

PubMed publication ID

2 September 2017

author name string

Maria Almeida

1

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Europe PubMed Central

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2 September 2017

Li Han

2

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Europe PubMed Central

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2 September 2017

Stavros C Manolagas

4

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Europe PubMed Central

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2 September 2017

Stavroula Kousteni

5

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2 September 2017

language of work or name

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publication date

25 October 2005

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Europe PubMed Central

PubMed publication ID

2 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

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2 September 2017

280

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Europe PubMed Central

PubMed publication ID

2 September 2017

50

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Europe PubMed Central

PubMed publication ID

2 September 2017

41342-41351

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Europe PubMed Central

PubMed publication ID

2 September 2017

The promise and perils of Wnt signaling through beta-catenin.

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Wnt proteins are lipid-modified and can act as stem cell growth factors

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Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface

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LDL-receptor-related proteins in Wnt signal transduction

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LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way

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Regulation of the protein kinase activity of Shaggy(Zeste-white3) by components of the wingless pathway in Drosophila cells and embryos

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Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

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Armadillo/beta-catenin signals in the nucleus--proof beyond a reasonable doubt?

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A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling

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LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development

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High bone density due to a mutation in LDL-receptor-related protein 5

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A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

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Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6

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Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

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High bone mass in mice expressing a mutant LRP5 gene

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The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice

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Beta-catenin and BMP-2 synergize to promote osteoblast differentiation and new bone formation.

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BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop

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21 January 2018

Wnt signaling inhibits osteogenic differentiation of human mesenchymal stem cells

1 reference

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21 January 2018

Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells

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21 January 2018

The Wnt signaling inhibitor dickkopf-1 is required for reentry into the cell cycle of human adult stem cells from bone marrow

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Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

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Identification of c-MYC as a target of the APC pathway

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Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

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Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

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Integrin engagement, the actin cytoskeleton, and c-Src are required for the calcitonin-induced tyrosine phosphorylation of paxillin and HEF1, but not for calcitonin-induced Erk1/2 phosphorylation

1 reference

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A short amino acid sequence able to specify nuclear location

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The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

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Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids

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Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling

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Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway

1 reference

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Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin

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Transient versus sustained phosphorylation and nuclear accumulation of ERKs underlie anti-versus pro-apoptotic effects of estrogens

1 reference

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Wnt1 and Wnt5a induce cyclin D1 expression through ErbB1 transactivation in HC11 mammary epithelial cells.

1 reference

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Wnt-7a causes loss of differentiated phenotype and inhibits apoptosis of articular chondrocytes via different mechanisms

1 reference

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Akt participation in the Wnt signaling pathway through Dishevelled

1 reference

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Both ERK and Wnt/beta-catenin pathways are involved in Wnt3a-induced proliferation

1 reference

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Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation

1 reference

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Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors

1 reference

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Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

1 reference

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The Wnt antagonist Dickkopf-1 is regulated by Bmp signaling and c-Jun and modulates programmed cell death

1 reference

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Wnt-frizzled signaling in the induction and differentiation of the neural crest

1 reference

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Early neural cell death: dying to become neurons

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Exogenous expression of beta-catenin regulates contact inhibition, anchorage-independent growth, anoikis, and radiation-induced cell cycle arrest

1 reference

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Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription

1 reference

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Protection against anoikis and down-regulation of cadherin expression by a regulatable beta-catenin protein

1 reference

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Inhibition of Wnt-1 signaling induces apoptosis in beta-catenin-deficient mesothelioma cells.

1 reference

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The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling

1 reference

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The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF.

1 reference

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Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development

1 reference

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Fibroblast growth factor-2 induces Lef/Tcf-dependent transcription in human endothelial cells.

1 reference

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Epidermal growth factor-mediated T-cell factor/lymphoid enhancer factor transcriptional activity is essential but not sufficient for cell cycle progression in nontransformed mammary epithelial cells

1 reference

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Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.

1 reference

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Wnt-1 regulation of connexin43 in cardiac myocytes

1 reference

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Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation

1 reference

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The deubiquitinating enzyme Fam interacts with and stabilizes beta-catenin

1 reference

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21 January 2018

Distinct molecular forms of beta-catenin are targeted to adhesive or transcriptional complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502168200

21 January 2018

Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover

1 reference

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21 January 2018

The APC tumour suppressor has a nuclear export function.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502168200

21 January 2018

Essential role of beta-catenin in postnatal bone acquisition

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502168200

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Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502168200

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Functional analysis of H-Ryk, an atypical member of the receptor tyrosine kinase family

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502168200

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Reversal of bone loss in mice by nongenotropic signaling of sex steroids

1 reference

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Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism

1 reference

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21 January 2018

Bisphosphonates and estrogens inhibit osteocyte apoptosis via distinct molecular mechanisms downstream of extracellular signal-regulated kinase activation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502168200

21 January 2018

Identifiers

10.1074/JBC.M502168200

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

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