Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism. (Q38337494)

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English	Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism.	scientific article

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31 December 2019

Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism (English)

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31 December 2019

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31 December 2019

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Sonali Bhalla

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31 December 2019

Sungsoon Fang

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31 December 2019

Lingjin Xiang

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31 December 2019

Jongsook Kim Kemper

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18 August 2004

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31 December 2019

Journal of Biological Chemistry

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31 December 2019

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31 December 2019

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31 December 2019

45139-45147

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31 December 2019

Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405423200

21 January 2018

Nuclear orphan receptors control cholesterol catabolism.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405423200

21 January 2018

Bile acid regulation of gene expression: roles of nuclear hormone receptors.

1 reference

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21 January 2018

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

1 reference

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21 January 2018

Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP.

1 reference

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21 January 2018

Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis

1 reference

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21 January 2018

Redundant pathways for negative feedback regulation of bile acid production

1 reference

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21 January 2018

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

1 reference

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21 January 2018

Rifampicin and treatment of cholestatic pruritus

1 reference

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21 January 2018

Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405423200

21 January 2018

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405423200

21 January 2018

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405423200

21 January 2018

The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405423200

21 January 2018

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405423200

21 January 2018

Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405423200

21 January 2018

Vitamin D receptor as an intestinal bile acid sensor

1 reference

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21 January 2018

Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405423200

21 January 2018

Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405423200

21 January 2018

Control of pancreas and liver gene expression by HNF transcription factors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405423200

21 January 2018

SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405423200

21 January 2018

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405423200

21 January 2018

Coordinated control of cholesterol catabolism to bile acids and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to-fed cycle

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405423200

21 January 2018

Exclusive Homodimerization of the Orphan Receptor Hepatocyte Nuclear Factor 4 Defines a New Subclass of Nuclear Receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405423200

21 January 2018

The orphan receptors COUP-TF and HNF-4 serve as accessory factors required for induction of phosphoenolpyruvate carboxykinase gene transcription by glucocorticoids

1 reference

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21 January 2018

A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405423200

21 January 2018

SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405423200

21 January 2018

Peroxisome proliferator-activated receptor gamma coactivator-1alpha, as a transcription amplifier, is not essential for basal and hormone-induced phosphoenolpyruvate carboxykinase gene expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405423200

21 January 2018

Inhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR). CAR inhibits ER-mediated signaling pathway by squelching p160 coactivators

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405423200

21 January 2018

Glucocorticoid receptor-interacting protein 1 mediates ligand-independent nuclear translocation and activation of constitutive androstane receptor in vivo

1 reference

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21 January 2018

Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription

1 reference

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21 January 2018

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405423200

21 January 2018

Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis

1 reference

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21 January 2018

Coregulator codes of transcriptional regulation by nuclear receptors

1 reference

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21 January 2018

Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1

1 reference

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21 January 2018

Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR

1 reference

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21 January 2018

Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

1 reference

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21 January 2018

Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405423200

21 January 2018

Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR

1 reference

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21 January 2018

Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator

1 reference

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21 January 2018

The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M405423200

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15322103%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15322103%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

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