SOCS3 negatively regulates IL-6 signaling in vivo (Q38354512)

2 September 2017

title

SOCS3 negatively regulates IL-6 signaling in vivo (English)

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Andrew W Roberts

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Nicos A. Nicola

Nicos A Nicola

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Björn E Clausen

Björn E Clausen

10

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Doug Hilton

Douglas J Hilton

13

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Donald Metcalf

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Donald Metcalf

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Tracy A Willson

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Danielle L Krebs

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Christopher J Greenhalgh

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Christopher J Greenhalgh

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Lorraine Robb

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4

Sam Wormald

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Jian-Guo Zhang

3

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Edouard G Stanley

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Warren S Alexander

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language of work or name

English

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publication date

18 May 2003

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volume

4

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issue

6

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page(s)

540-545

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Interleukin-6 is required in vivo for the regulation of stem cells and committed progenitors of the hematopoietic system.

2 September 2017

cites work

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7 January 2021

The role of interleukin-6 in mucosal IgA antibody responses in vivo

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7 January 2021

Defective inflammatory response in interleukin 6-deficient mice

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7 January 2021

Interleukin 6 is essential for in vivo development of B lineage neoplasms

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7 January 2021

Impaired immune and acute-phase responses in interleukin-6-deficient mice.

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7 January 2021

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

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7 January 2021

Cytokine signaling in 2002: new surprises in the Jak/Stat pathway

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7 January 2021

Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activation

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7 January 2021

Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation [correction of activation] in the liver

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7 January 2021

Suppressors of cytokine signalling (SOCS) in the immune system

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7 January 2021

A family of cytokine-inducible inhibitors of signalling

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7 January 2021

SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.

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7 January 2021

SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality

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7 January 2021

Gigantism in mice lacking suppressor of cytokine signalling-2

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7 January 2021

Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3

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7 January 2021

SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation

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7 January 2021

SOCS3 is essential in the regulation of fetal liver erythropoiesis

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7 January 2021

A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells

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7 January 2021

Normal growth and development in the absence of hepatic insulin-like growth factor I

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7 January 2021

Conditional gene targeting in macrophages and granulocytes using LysMcre mice.

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7 January 2021

Generalized lacZ expression with the ROSA26 Cre reporter strain

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7 January 2021

Expression of suppressors of cytokine signaling during liver regeneration

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7 January 2021

Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS.

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7 January 2021

Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

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7 January 2021

The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities

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7 January 2021

Suppressor of Cytokine Signaling-1 Attenuates the Duration of Interferon γ Signal Transductionin Vitroandin Vivo

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7 January 2021

Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.

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7 January 2021

Interferon γ Induces the Expression of p21waf-1 and Arrests Macrophage Cell Cycle, Preventing Induction of Apoptosis

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7 January 2021

Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice.

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7 January 2021

Mutational switch of an IL-6 response to an interferon-gamma-like response

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7 January 2021

STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation

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7 January 2021

SOCS3 regulates the plasticity of gp130 signaling

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7 January 2021

Hepatocytes induce functional activation of naive CD8+ T lymphocytes but fail to promote survival

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7 January 2021

Identifiers

DOI

10.1038/NI931

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2 September 2017

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