Regulation of biglycan gene expression by transforming growth factor-beta requires MKK6-p38 mitogen-activated protein Kinase signaling downstream of Smad signaling (Q38358454)

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English	Regulation of biglycan gene expression by transforming growth factor-beta requires MKK6-p38 mitogen-activated protein Kinase signaling downstream of Smad signaling	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

2 September 2017

Regulation of biglycan gene expression by transforming growth factor-beta requires MKK6-p38 mitogen-activated protein Kinase signaling downstream of Smad signaling (English)

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Europe PubMed Central

PubMed publication ID

2 September 2017

author name string

Hendrik Ungefroren

1

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Europe PubMed Central

PubMed publication ID

2 September 2017

Wolfgang Lenschow

2

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Europe PubMed Central

PubMed publication ID

2 September 2017

Wen-Bin Chen

3

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Europe PubMed Central

PubMed publication ID

2 September 2017

Fred Faendrich

4

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Europe PubMed Central

PubMed publication ID

2 September 2017

Holger Kalthoff

5

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Europe PubMed Central

PubMed publication ID

2 September 2017

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publication date

20 January 2003

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Europe PubMed Central

PubMed publication ID

2 September 2017

number of pages

9

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Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

2 September 2017

278

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Europe PubMed Central

PubMed publication ID

2 September 2017

13

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Europe PubMed Central

PubMed publication ID

2 September 2017

11041-11049

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Europe PubMed Central

PubMed publication ID

2 September 2017

TGF-beta signal transduction

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Transforming growth factor beta in tissue fibrosis

1 reference

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Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor

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Mechanism of activation of the TGF-beta receptor

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TGF-beta signalling from cell membrane to nucleus through SMAD proteins

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Transcriptional control by the TGF-beta/Smad signaling system

1 reference

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Smad6 inhibits signalling by the TGF-beta superfamily

1 reference

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Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA

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Transforming growth factor beta activation of p44mapk in proliferating cultures of epithelial cells

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TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

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ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling

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Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism

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TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses

1 reference

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Transcriptional cross-talk between Smad, ERK1/2, and p38 mitogen-activated protein kinase pathways regulates transforming growth factor-beta-induced aggrecan gene expression in chondrogenic ATDC5 cells

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Smad-dependent GADD45beta expression mediates delayed activation of p38 MAP kinase by TGF-beta

1 reference

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21 January 2018

How cells read TGF-beta signals

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TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

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Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta.

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21 January 2018

c-myc is a downstream target of the Smad pathway

1 reference

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The family of the small leucine-rich proteoglycans: key regulators of matrix assembly and cellular growth

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21 January 2018

Leucine-rich repeat glycoproteins of the extracellular matrix

1 reference

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21 January 2018

Expression of small extracellular chondroitin/dermatan sulfate proteoglycans is differentially regulated in human endothelial cells

1 reference

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21 January 2018

Proteoglycans as modulators of growth factor activities

1 reference

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21 January 2018

Biglycan is overexpressed in pancreatic cancer and induces G1-arrest in pancreatic cancer cell lines

1 reference

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21 January 2018

Smad4/DPC4-dependent regulation of biglycan gene expression by transforming growth factor-beta in pancreatic tumor cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300035200

21 January 2018

The p38 signal transduction pathway: activation and function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300035200

21 January 2018

Transcriptional regulation of the human biglycan gene

1 reference

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21 January 2018

Transduction of human pancreatic tumor cells with vesicular stomatitis virus G-pseudotyped retroviral vectors containing a herpes simplex virus thymidine kinase mutant gene enhances bystander effects and sensitivity to ganciclovir

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Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution

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Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542

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21 January 2018

Hypertensive end-organ damage and premature mortality are p38 mitogen-activated protein kinase-dependent in a rat model of cardiac hypertrophy and dysfunction

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21 January 2018

TGFbeta1 represses proliferation of pancreatic carcinoma cells which correlates with Smad4-independent inhibition of ERK activation

1 reference

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21 January 2018

MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway

1 reference

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21 January 2018

The stress inducer arsenite activates mitogen-activated protein kinases extracellular signal-regulated kinases 1 and 2 via a MAPK kinase 6/p38-dependent pathway

1 reference

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21 January 2018

Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

1 reference

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21 January 2018

X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-beta signaling

1 reference

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21 January 2018

Transforming growth factor-beta-induced osteoblast elongation regulates osteoclastic bone resorption through a p38 mitogen-activated protein kinase- and matrix metalloproteinase-dependent pathway.

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Apoptosis in podocytes induced by TGF-beta and Smad7

1 reference

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p38-mediated regulation of an Fas-associated death domain protein-independent pathway leading to caspase-8 activation during TGFbeta-induced apoptosis in human Burkitt lymphoma B cells BL41.

1 reference

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Rac1-MKK3-p38-MAPKAPK2 pathway promotes urokinase plasminogen activator mRNA stability in invasive breast cancer cells

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c-Abl-induced apoptosis, but not cell cycle arrest, requires mitogen-activated protein kinase kinase 6 activation

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Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression

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Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice

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MEK/ERK-mediated proliferation is negatively regulated by P38 map kinase in the human pancreatic cancer cell line, PANC-1.

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A Role for p38MAPK/HSP27 Pathway in Smooth Muscle Cell Migration

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TGF-beta signaling in tumor suppression and cancer progression

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Identifiers

10.1074/JBC.M300035200

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

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