Investigational drugs targeting 5-HT6 receptors for the treatment of Alzheimer's disease. (Q38627971)

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29 February 2020

title

Investigational drugs targeting 5-HT6 receptors for the treatment of Alzheimer's disease (English)

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29 February 2020

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3

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29 February 2020

author name string

Karsten Wicke

series ordinal

1

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29 February 2020

Andreas Haupt

series ordinal

2

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29 February 2020

language of work or name

English

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publication date

7 November 2015

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Expert Opinion on Investigational Drugs

29 February 2020

published in

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29 February 2020

volume

24

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issue

12

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29 February 2020

page(s)

1515-1528

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Pharmacological recommendations for the symptomatic treatment of dementia: the Canadian Consensus Conference on the Diagnosis and Treatment of Dementia 2012.

29 February 2020

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5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease

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5‐HT6 receptor antagonist SB‐271046 enhances extracellular levels of monoamines in the rat medial prefrontal cortex

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Increased expression of 5-HT6 receptors in the rat dorsomedial striatum impairs instrumental learning

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SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models.

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The 5-HT6 Receptor Antagonist SB-271046 Reverses Scopolamine-Disrupted Consolidation of a Passive Avoidance Task and Ameliorates Spatial Task Deficits in Aged Rats

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Excess of serotonin affects embryonic interneuron migration through activation of the serotonin receptor 6.

21 January 2018

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21 January 2018

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21 January 2018

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Targeting of ECM molecules and their metabolizing enzymes and receptors for the treatment of CNS diseases

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Antagonist functional selectivity: 5-HT2A serotonin receptor antagonists differentially regulate 5-HT2A receptor protein level in vivo

21 January 2018

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Double-blind, controlled phase II study of a 5-HT6 receptor antagonist, SB-742457, in Alzheimer's disease

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Differential involvement of 5-HT(1B/1D) and 5-HT6 receptors in cognitive and non-cognitive symptoms in Alzheimer's disease

21 January 2018

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(11)C-labeling and preliminary evaluation of pimavanserin as a 5-HT2A receptor PET-radioligand

21 January 2018

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10.1517/13543784.2015.1102884

21 January 2018

Identifiers

DOI

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29 February 2020

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