Mechanisms of Doxorubicin Toxicity in Pancreatic β-Cells (Q38766953)

6 September 2017

Mechanisms of Doxorubicin Toxicity in Pancreatic β-Cells (English)

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6 September 2017

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Emma A Heart

1

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6 September 2017

Shpetim Karandrea

2

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6 September 2017

Xiaomei Liang

3

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6 September 2017

Maren E Balke

4

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6 September 2017

Patrick A Beringer

5

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6 September 2017

Elyse M Bobczynski

6

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6 September 2017

Delaine Zayas-Bazán Burgos

7

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6 September 2017

Tiffany Richardson

8

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6 September 2017

Joshua P Gray

9

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6 September 2017

2 June 2016

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6 September 2017

Toxicological Sciences

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6 September 2017

152

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6 September 2017

2

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6 September 2017

395-405

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Doxorubicin caused severe hyperglycaemia and insulin resistance, mediated by inhibition in AMPk signalling in skeletal muscle.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

Impact of Doxorubicin Treatment on the Physiological Functions of White Adipose Tissue.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

Clinical pathological characteristics of breast cancer patients with secondary diabetes after systemic therapy: a retrospective multicenter study

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

Clinical and molecular mechanisms favoring cancer initiation and progression in diabetic patients.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

Diabetes and cancer: two diseases with obesity as a common risk factor

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

Identification of the molecular basis of doxorubicin-induced cardiotoxicity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

The level of menadione redox-cycling in pancreatic β-cells is proportional to the glucose concentration: role of NADH and consequences for insulin secretion

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

Beta-cell growth and regeneration: replication is only part of the story

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

Usurping the mitochondrial supremacy: extramitochondrial sources of reactive oxygen intermediates and their role in beta cell metabolism and insulin secretion.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

Diabetes mellitus among cancer survivors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

The mechanisms of alloxan- and streptozotocin-induced diabetes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

Cell lines derived from pancreatic islets

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

Stimulated endocrine cell proliferation and differentiation in transplanted human pancreatic islets: effects of the ob gene and compensatory growth of the implantation organ.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

Mechanisms of anti-cancer agents: emphasis on oxidative stress and electron transfer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

NMR in cancer, XIII: application of the NMR malignancy index to human mammary tumours

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

Anthracycline antibiotic augmentation of microsomal electron transport and free radical formation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

The role of bioreductive activation of doxorubicin in cytotoxic activity against leukaemia HL60-sensitive cell line and its multidrug-resistant sublines.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

Study of caspase inhibitors for limiting death in mammalian cell culture

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

Inhibition of caspase activity delays apoptosis in a transfected NS/0 myeloma cell line

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

Phenobarbital-induced cytosolic cytoprotective mechanisms that offset increases in NADPH cytochrome P450 reductase activity in menadione-mediated cytotoxicity

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

Plasma membrane electron transport in pancreatic β-cells is mediated in part by NQO1.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

One-electron reduction of adriamycin: properties of the semiquinone.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

Effect of vitamin E on toxicity and antitumor activity of adriamycin in mice

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

Redox cycling of anthracyclines by cardiac mitochondria. II. Formation of superoxide anion, hydrogen peroxide, and hydroxyl radical.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

In vivo Studies on the Protective Effect of Propolis on Doxorubicin-Induced Toxicity in Liver of Male Rats

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

Secondary diabetes associated with 5-fluorouracil-based chemotherapy regimens in non-diabetic patients with colorectal cancer: results from a single-centre cohort study.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

Paraquat increases cyanide-insensitive respiration in murine lung epithelial cells by activating an NAD(P)H:paraquat oxidoreductase: identification of the enzyme as thioredoxin reductase.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960911

Relevance of interstrand DNA crosslinking induced by anthracyclines for their biological activity

31 August 2018

1 reference

12 December 2020

Direct enzyme-catalyzed reduction of anthracyclines by reduced nicotinamide adenine dinucleotide

1 reference

12 December 2020

Reconstruction of large defects that include the mandible with scapular osteocutaneous and forearm flaps: report of cases

1 reference

12 December 2020

Interstrand DNA crosslinking induced by anthracyclines in tumour cells

1 reference

12 December 2020

Effects of a water-soluble prodrug of vitamin E on doxorubicin-induced toxicity in mice

1 reference

12 December 2020

Doxorubicin-induced cardiomyopathy

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12 December 2020

Adriamycin: the role of lipid peroxidation in cardiac toxicity and tumor response

1 reference

12 December 2020

Depletion in vitro of mitochondrial glutathione in rat hepatocytes and enhancement of lipid peroxidation by adriamycin and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)

1 reference

12 December 2020

DNA topoisomerase II-mediated interaction of doxorubicin and daunorubicin congeners with DNA

1 reference

12 December 2020

Insulin dependent diabetes mellitus induced by chemotherapy and granulocyte, macrophage--colony stimulating factor

1 reference

12 December 2020

Adriamycin effects on insulin secretion, Ca2+ movements and glucose oxidation in pancreatic islet cells

1 reference

12 December 2020

Study of the adriamycin-cardiolipin complex structure using attenuated total reflection infrared spectroscopy

1 reference

12 December 2020

Chemotherapy-induced insulin-dependent diabetes mellitus

1 reference

12 December 2020

Doxorubicin treatment inhibits PPARγ and may induce lipotoxicity by mimicking a type 2 diabetes-like condition in rodent models

1 reference

12 December 2020

[Diabetes and cancer risk: oncologic considerations]

1 reference

12 December 2020

Spin-trapping and direct electron spin resonance investigations of the redox metabolism of quinone anticancer drugs

1 reference

12 December 2020

Identifiers

DOI

10.1093/TOXSCI/KFW096

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6 September 2017

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6 September 2017

PubMed publication ID

27255381

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