BET Proteins: An Approach to Future Therapies in Transplantation. (Q38760291)

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2 April 2020

title

BET Proteins: An Approach to Future Therapies in Transplantation (English)

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2 April 2020

3

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2 April 2020

Carlos López-Larrea

series ordinal

4

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2 April 2020

author name string

B Suarez-Alvarez

series ordinal

1

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2 April 2020

R M Rodriguez

series ordinal

2

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language of work or name

English

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publication date

10 March 2017

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American Journal of Transplantation

2 April 2020

published in

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2 April 2020

volume

17

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2 April 2020

issue

9

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2 April 2020

page(s)

2254-2262

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A brief history of epigenetics

2 April 2020

cites work

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Epigenetic modifications and human disease

21 January 2018

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Epigenetic modulation of the immune function: a potential target for tolerance

21 January 2018

1 reference

The Emerging Role of DNA Methylation in Kidney Transplantation: A Perspective

21 January 2018

1 reference

Epigenetics in Kidney Transplantation: Current Evidence, Predictions, and Future Research Directions.

21 January 2018

1 reference

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

21 January 2018

1 reference

The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis

21 January 2018

1 reference

BET bromodomains mediate transcriptional pause release in heart failure

21 January 2018

1 reference

Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors

21 January 2018

1 reference

The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts.

21 January 2018

1 reference

Beating the odds: BETs in disease

21 January 2018

1 reference

Selective inhibition of BET bromodomains

21 January 2018

1 reference

Histone recognition and large-scale structural analysis of the human bromodomain family

21 January 2018

1 reference

The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.

21 January 2018

1 reference

Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release

21 January 2018

1 reference

The mechanisms behind the therapeutic activity of BET bromodomain inhibition

21 January 2018

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The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

21 January 2018

1 reference

BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain

21 January 2018

1 reference

BET Bromodomain Inhibition Releases the Mediator Complex from Select cis-Regulatory Elements

21 January 2018

1 reference

The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription

21 January 2018

1 reference

Selective inhibition of tumor oncogenes by disruption of super-enhancers

21 January 2018

1 reference

NF-κB directs dynamic super enhancer formation in inflammation and atherogenesis

21 January 2018

1 reference

Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

21 January 2018

1 reference

Immunosuppressive potency of mechanistic target of rapamycin inhibitors in solid-organ transplantation

21 January 2018

1 reference

Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation

21 January 2018

1 reference

The bromodomain protein Brd4 stimulates G1 gene transcription and promotes progression to S phase

21 January 2018

1 reference

The double bromodomain protein Brd2 promotes B cell expansion and mitogenesis.

21 January 2018

1 reference

BET bromodomain inhibition as a novel strategy for reactivation of HIV-1

21 January 2018

1 reference

Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma

21 January 2018

1 reference

Regulation of MYC expression and differential JQ1 sensitivity in cancer cells

21 January 2018

1 reference

Targeting MYC dependence in cancer by inhibiting BET bromodomains

21 January 2018

1 reference

DNA methylation: a promising landscape for immune system-related diseases.

21 January 2018

1 reference

Epigenetic dynamics during CD4(+) T cells lineage commitment

21 January 2018

1 reference

A validated regulatory network for Th17 cell specification

21 January 2018

1 reference

BET bromodomain inhibition suppresses TH17-mediated pathology

21 January 2018

1 reference

Urinary mRNA for the Diagnosis of Renal Allograft Rejection: The Issue of Normalization

21 January 2018

1 reference

BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models

21 January 2018

1 reference

T Follicular Helper Cells in Transplantation.

21 January 2018

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The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells

21 January 2018

1 reference

NF-kappaB RelA phosphorylation regulates RelA acetylation

21 January 2018

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Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA

21 January 2018

1 reference

Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA

21 January 2018

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BET protein function is required for inflammation: Brd2 genetic disruption and BET inhibitor JQ1 impair mouse macrophage inflammatory responses.

21 January 2018

1 reference

Suppression of inflammation by a synthetic histone mimic

21 January 2018

1 reference

Inhibiting STAT5 by the BET bromodomain inhibitor JQ1 disrupts human dendritic cell maturation

21 January 2018

1 reference

BET bromodomain inhibition suppresses graft-versus-host disease after allogeneic bone marrow transplantation in mice

21 January 2018

1 reference

Inhibition of Bromodomain and Extraterminal Domain Family Proteins Ameliorates Experimental Renal Damage.

21 January 2018

1 reference

HIF1α protein stability is increased by acetylation at lysine 709.

21 January 2018

1 reference

HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia

21 January 2018

1 reference

Class-specific histone/protein deacetylase inhibition protects against renal ischemia reperfusion injury and fibrosis formation

21 January 2018

1 reference

Peroxisome proliferator-activated receptor-gamma abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator

21 January 2018

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P300-dependent STAT3 acetylation is necessary for angiotensin II-induced pro-fibrotic responses in renal tubular epithelial cells

21 January 2018

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Novel curcumin analog C66 prevents diabetic nephropathy via JNK pathway with the involvement of p300/CBP-mediated histone acetylation

21 January 2018

1 reference

Blocking the class I histone deacetylase ameliorates renal fibrosis and inhibits renal fibroblast activation via modulating TGF-beta and EGFR signaling

21 January 2018

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Assessment of Brd4 inhibition in idiopathic pulmonary fibrosis lung fibroblasts and in vivo models of lung fibrosis

21 January 2018

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Synergistic action of master transcription factors controls epithelial-to-mesenchymal transition

21 January 2018

1 reference

Discovery of Chemical Inhibitors of Human Bromodomains

21 January 2018

1 reference

Potent and selective bivalent inhibitors of BET bromodomains.

21 January 2018

1 reference

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.

21 January 2018

1 reference

Dual kinase-bromodomain inhibitors for rationally designed polypharmacology

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/AJT.14221

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28173625%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

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