Merlin sumoylation is required for its tumor suppressor activity (Q39069340)

8 September 2017

title

Merlin sumoylation is required for its tumor suppressor activity (English)

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8 September 2017

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Q Qi

1

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8 September 2017

X Liu

series ordinal

2

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8 September 2017

D J Brat

series ordinal

3

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8 September 2017

K Ye

series ordinal

4

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8 September 2017

language of work or name

English

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publication date

28 October 2013

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8 September 2017

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8 September 2017

volume

33

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8 September 2017

issue

41

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8 September 2017

page(s)

4893-4903

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8 September 2017

cites work

Neurofibromatosis Type 2

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Loss of the tumor suppressor gene NF2, encoding merlin, constitutively activates integrin-dependent mTORC1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Localization to the cortical cytoskeleton is necessary for Nf2/merlin-dependent epidermal growth factor receptor silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Dissecting and targeting the growth factor-dependent and growth factor-independent extracellular signal-regulated kinase pathway in human schwannoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE-L

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Re-expression of the tumor suppressor NF2/merlin inhibits invasiveness in mesothelioma cells and negatively regulates FAK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Akt phosphorylation of merlin enhances its binding to phosphatidylinositols and inhibits the tumor-suppressive activities of merlin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Defects in neurofibromatosis 2 protein function can arise at multiple levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Interaction between two isoforms of the NF2 tumor suppressor protein, merlin, and between merlin and ezrin, suggests modulation of ERM proteins by merlin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Activation of p21-activated kinase 2 by human immunodeficiency virus type 1 Nef induces merlin phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

p21-activated kinase links Rac/Cdc42 signaling to merlin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

SUMOylation in carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

SUMO, ubiquitin's mysterious cousin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Regulation and function of SUMO modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

SUMOylation and deSUMOylation at a glance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

SUMO-1 modification activates the transcriptional response of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Merlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Compensative shuttling of merlin to phosphorylation on serine 518 in vestibular schwannoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Serine 518 phosphorylation modulates merlin intramolecular association and binding to critical effectors important for NF2 growth suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Cyclic AMP-dependent protein kinase phosphorylates merlin at serine 518 independently of p21-activated kinase and promotes merlin-ezrin heterodimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

FERM domain phosphoinositide binding targets merlin to the membrane and is essential for its growth-suppressive function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

NF2deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Merlin regulates transmembrane receptor accumulation and signaling at the plasma membrane in primary mouse Schwann cells and in human schwannomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

SUMO and ubiquitin in the nucleus: different functions, similar mechanisms?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Contact-dependent inhibition of EGFR signaling by Nf2/Merlin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Merlin is a potent inhibitor of glioma growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Sumoylation increases HIF-1alpha stability and its transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Pax8 protein stability is controlled by sumoylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Sumoylation silences the plasma membrane leak K+ channel K2P1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

SUMOylation regulates kainate-receptor-mediated synaptic transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Binary regulation of Hippo pathway by Merlin/NF2, Kibra, Lgl, and Melted specifies and maintains postmitotic neuronal fate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Merlin is a negative regulator of human melanoma growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Nucleocytoplasmic transfer of the NF2 tumor suppressor protein merlin is regulated by exon 2 and a CRM1-dependent nuclear export signal in exon 15.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Deciphering the nuclear import pathway for the cytoskeletal red cell protein 4.1R.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Cell cycle-dependent nucleocytoplasmic shuttling of the neurofibromatosis 2 tumour suppressor merlin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Agonist-induced PKC phosphorylation regulates GluK2 SUMOylation and kainate receptor endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

MAPK-induced Ser727 phosphorylation promotes SUMOylation of STAT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

The tumor suppressor merlin controls growth in its open state, and phosphorylation converts it to a less-active more-closed state.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Inhibition of CtBP1 activity by Akt-mediated phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

PTEN regulation by Akt-EGR1-ARF-PTEN axis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Increased expression of the NF2 tumor suppressor gene product, merlin, impairs cell motility, adhesionand spreading

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Neurofibromatosis 2 tumor suppressor protein, merlin, forms two functionally important intramolecular associations

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Interdomain binding mediates tumor growth suppression by the NF2 gene product

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

Interdomain interaction of merlin isoforms and its influence on intermolecular binding to NHE-RF

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.438

31 March 2020

Identifiers

DOI

10.1038/ONC.2013.438

1 reference

release_xwvu4dog4rgjjnq2hrqhcojy5e

8 September 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/xwvu4dog4rgjjnq2hrqhcojy5e

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference