Super-resolution imaging of alpha-synuclein polymorphisms and their potential role in neurodegeneration. (Q39127625)

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2 April 2020

title

Super-resolution imaging of alpha-synuclein polymorphisms and their potential role in neurodegeneration (English)

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2 April 2020

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2

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2 April 2020

author name string

Eileen Nugent

series ordinal

1

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2 April 2020

Gabriele S Kaminski Schierle

series ordinal

3

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2 April 2020

publication date

9 February 2017

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2 April 2020

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2 April 2020

volume

9

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2 April 2020

issue

3

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2 April 2020

page(s)

206-210

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Prion-like spreading of pathological α-synuclein in brain

2 April 2020

cites work

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Prions: generation and spread versus neurotoxicity.

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A structure-toxicity study of Aß42 reveals a new anti-parallel aggregation pathway

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In vivo demonstration that alpha-synuclein oligomers are toxic

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Structural polymorphism of amyloid oligomers and fibrils underlies different fibrillization pathways: immunogenicity and cytotoxicity.

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Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

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Parkinson's disease and α-synuclein expression

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Stepwise dynamics of epitaxially growing single amyloid fibrils

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Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils

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Seeded growth of beta-amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure

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Glucagon amyloid-like fibril morphology is selected via morphology-dependent growth inhibition.

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Visualization and classification of amyloid beta supramolecular assemblies

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Abeta(1-40) forms five distinct amyloid structures whose beta-sheet contents and fibril stabilities are correlated

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Intrinsic Linear Heterogeneity of Amyloid β Protein Fibrils Revealed by Higher Resolution Mass-per-length Determinations

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Direct observation of heterogeneous amyloid fibril growth kinetics via two-color super-resolution microscopy

21 January 2018

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Novel mechanistic insight into the molecular basis of amyloid polymorphism and secondary nucleation during amyloid formation

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Subdiffraction-resolution fluorescence imaging with conventional fluorescent probes

21 January 2018

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In situ measurements of the formation and morphology of intracellular β-amyloid fibrils by super-resolution fluorescence imaging

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Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons

21 January 2018

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Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

21 January 2018

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Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

21 January 2018

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Neuropathology in transplants in Parkinson's disease: implications for disease pathogenesis and the future of cell therapy

21 January 2018

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Long-term clinical outcome of fetal cell transplantation for Parkinson disease: two case reports

21 January 2018

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Long-term health of dopaminergic neuron transplants in Parkinson's disease patients.

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Human ESC-derived dopamine neurons show similar preclinical efficacy and potency to fetal neurons when grafted in a rat model of Parkinson's disease

21 January 2018

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21 January 2018

Identifiers

DOI

10.1039/C6IB00206D

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28180219%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

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