Cytokines in inflammatory bowel disease (Q39206254)

10 September 2017

title

Cytokines in inflammatory bowel disease (English)

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inflammatory bowel diseases

10 September 2017

main subject

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inflammation

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author name string

Markus F Neurath

series ordinal

1

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10 September 2017

publication date

22 April 2014

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Nature Reviews Immunology

10 September 2017

published in

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10 September 2017

volume

14

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10 September 2017

issue

5

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10 September 2017

page(s)

329-342

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10 September 2017

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31 March 2020

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The immunology of mucosal models of inflammation

31 March 2020

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Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

31 March 2020

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The role of Th1/Th2 polarization in mucosal immunity

31 March 2020

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Subclinical intestinal inflammation in patients with Crohn's disease following bowel resection: a smoldering fire

31 March 2020

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Long-term complications, extraintestinal manifestations, and mortality in adult Crohn's disease in population-based cohorts

31 March 2020

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TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.

31 March 2020

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T-cell abnormalities in inflammatory bowel disease are mediated by interleukin 2

31 March 2020

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Significance of interleukin-6 in patients with inflammatory bowel disease

31 March 2020

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Antibodies to interleukin 12 abrogate established experimental colitis in mice

31 March 2020

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Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

31 March 2020

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Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy

31 March 2020

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Role of IL-10 for induction of anemia during inflammation

31 March 2020

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Randomized, double blind controlled trial of subcutaneous recombinant human interleukin-11 versus prednisolone in active Crohn's disease.

31 March 2020

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Interferon-beta-1a for the treatment of steroid-refractory ulcerative colitis: a randomized, double-blind, placebo-controlled trial

31 March 2020

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Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2).

31 March 2020

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Review article: the role of anti-TNF in the management of ulcerative colitis -- past, present and future

31 March 2020

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Mucosal healing in inflammatory bowel diseases: a systematic review

31 March 2020

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A dose escalating, placebo controlled, double blind, single dose and multidose, safety and tolerability study of fontolizumab, a humanised anti-interferon gamma antibody, in patients with moderate to severe Crohn's disease

31 March 2020

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Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

31 March 2020

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Relationship between human intestinal dendritic cells, gut microbiota, and disease activity in Crohn's disease

31 March 2020

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IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells

31 March 2020

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Interleukin 1 (IL-1) gene expression, synthesis, and effect of specific IL-1 receptor blockade in rabbit immune complex colitis

31 March 2020

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Neutralization of tumour necrosis factor (TNF) but not of IL-1 reduces inflammation in chronic dextran sulphate sodium-induced colitis in mice

31 March 2020

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Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease

31 March 2020

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Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production

31 March 2020

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Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo

31 March 2020

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Colitis in mice lacking the common cytokine receptor gamma chain is mediated by IL-6-producing CD4+ T cells

31 March 2020

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Increased Th17-inducing activity of CD14+ CD163 low myeloid cells in intestinal lamina propria of patients with Crohn's disease

31 March 2020

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IL-6 is required for the development of Th1 cell-mediated murine colitis

31 March 2020

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A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease

31 March 2020

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Antibodies against tumor necrosis factor (TNF) induce T-cell apoptosis in patients with inflammatory bowel diseases via TNF receptor 2 and intestinal CD14⁺ macrophages.

31 March 2020

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TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis.

31 March 2020

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Functional modulation of Crohn's disease myofibroblasts by anti-tumor necrosis factor antibodies

31 March 2020

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Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis.

31 March 2020

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Effect of the anti-tumor necrosis factor-alpha antibody infliximab on the ex vivo mucosal matrix metalloproteinase-proteolytic phenotype in inflammatory bowel disease

31 March 2020

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Tumor necrosis factor-receptor 2 is up-regulated on lamina propria T cells in Crohn's disease and promotes experimental colitis in vivo

31 March 2020

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Neutralization of membrane TNF, but not soluble TNF, is crucial for the treatment of experimental colitis

31 March 2020

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Prediction of antitumour necrosis factor clinical efficacy by real-time visualisation of apoptosis in patients with Crohn's disease

31 March 2020

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Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn's disease

31 March 2020

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Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells

31 March 2020

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The increased expression of IL-23 in inflammatory bowel disease promotes intraepithelial and lamina propria lymphocyte inflammatory responses and cytotoxicity

31 March 2020

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Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology.

31 March 2020

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IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6

31 March 2020

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Interleukin-23 drives intestinal inflammation through direct activity on T cells

31 March 2020

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Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis

31 March 2020

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Anti-interleukin-12 antibody for active Crohn's disease

31 March 2020

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Ustekinumab induction and maintenance therapy in refractory Crohn's disease

31 March 2020

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IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD

31 March 2020

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IL-27 promotes T cell-dependent colitis through multiple mechanisms

31 March 2020

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IL-27, targeting antigen-presenting cells, promotes Th17 differentiation and colitis in mice.

31 March 2020

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Oral delivery of IL-27 recombinant bacteria attenuates immune colitis in mice

31 March 2020

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Interleukin-35 mediates mucosal immune responses that protect against T-cell-dependent colitis.

31 March 2020

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IL-27 regulates homeostasis of the intestinal CD4+ effector T cell pool and limits intestinal inflammation in a murine model of colitis

31 March 2020

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Type I IFNs regulate effector and regulatory T cell accumulation and anti-inflammatory cytokine production during T cell-mediated colitis.

31 March 2020

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Toll-like receptor 9-induced type I IFN protects mice from experimental colitis

31 March 2020

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Topical treatment with the Toll-like receptor agonist DIMS0150 has potential for lasting relief of symptoms in patients with chronic active ulcerative colitis by restoring glucocorticoid sensitivity

31 March 2020

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Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology.

31 March 2020

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IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease

31 March 2020

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Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

31 March 2020

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Interleukin-15-dependent NKp46+ innate lymphoid cells control intestinal inflammation by recruiting inflammatory monocytes.

31 March 2020

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Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells

31 March 2020

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Lyn activity protects mice from DSS colitis and regulates the production of IL-22 from innate lymphoid cells.

31 March 2020

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Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation.

31 March 2020

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Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract

31 March 2020

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IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis.

31 March 2020

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STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

31 March 2020

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IL-23R+ innate lymphoid cells induce colitis via interleukin-22-dependent mechanism

31 March 2020

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The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis

31 March 2020

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Spontaneous release of interferon gamma by intestinal lamina propria lymphocytes in Crohn's disease. Kinetics of in vitro response to interferon gamma inducers

31 March 2020

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Th1/Th17 immune response is induced by mesenteric lymph node dendritic cells in Crohn's disease.

31 March 2020

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Up-regulation of the IL-12 receptor beta 2 chain in Crohn's disease

31 March 2020

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The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease

31 March 2020

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Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells

31 March 2020

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Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet

31 March 2020

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T-bet: a bridge between innate and adaptive immunity.

31 March 2020

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T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells

31 March 2020

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The role of IL-13 and NK T cells in experimental and human ulcerative colitis

31 March 2020

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Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells

31 March 2020

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Blocking IL-25 signalling protects against gut inflammation in a type-2 model of colitis by suppressing nuocyte and NKT derived IL-13

31 March 2020

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Absence of a role for interleukin-13 in inflammatory bowel disease

31 March 2020

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Induction of intestinal Th17 cells by segmented filamentous bacteria

31 March 2020

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Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells

31 March 2020

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IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease

31 March 2020

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Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease

31 March 2020

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Interferon-gamma-expressing cells are a major source of interleukin-21 in inflammatory bowel diseases

31 March 2020

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The role of the novel Th17 cytokine IL-26 in intestinal inflammation

31 March 2020

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TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease.

31 March 2020

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Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation

31 March 2020

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Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21.

31 March 2020

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Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease

31 March 2020

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IL-22-producing CD4+ cells are depleted in actively inflamed colitis tissue

31 March 2020

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A protective function for interleukin 17A in T cell-mediated intestinal inflammation

31 March 2020

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RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F.

31 March 2020

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Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease

31 March 2020

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T-helper 17 and interleukin-17-producing lymphoid tissue inducer-like cells make different contributions to colitis in mice.

31 March 2020

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Regulatory T cells suppress development of colitis, blocking differentiation of T-helper 17 into alternative T-helper 1 cells.

31 March 2020

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Fontolizumab in moderate to severe Crohn's disease: a phase 2, randomized, double-blind, placebo-controlled, multiple-dose study

31 March 2020

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An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation

31 March 2020

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A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells

31 March 2020

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Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner

31 March 2020

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T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice.

31 March 2020

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Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor

31 March 2020

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Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms

31 March 2020

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CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner.

31 March 2020

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Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10

31 March 2020

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The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis

31 March 2020

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Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease

31 March 2020

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Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression.

31 March 2020

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TGF-β limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function

31 March 2020

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Phase I clinical trial of Smad7 knockdown using antisense oligonucleotide in patients with active Crohn's disease

31 March 2020

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Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease.

31 March 2020

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Safety and efficacy of antigen-specific regulatory T-cell therapy for patients with refractory Crohn's disease

31 March 2020

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Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis

31 March 2020

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IL-33 attenuates development and perpetuation of chronic intestinal inflammation

31 March 2020

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IL-33 is a crucial amplifier of innate rather than acquired immunity

31 March 2020

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Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice

31 March 2020

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Epithelial expression of interleukin-37b in inflammatory bowel disease

31 March 2020

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Interleukin 37 expression protects mice from colitis

31 March 2020

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Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways

31 March 2020

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Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK

31 March 2020

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IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

31 March 2020

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gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.

31 March 2020

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Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells

31 March 2020

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IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

31 March 2020

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Neutrophil infiltration favors colitis-associated tumorigenesis by activating the interleukin-1 (IL-1)/IL-6 axis.

31 March 2020

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Transcription factor NFATc2 controls the emergence of colon cancer associated with IL-6-dependent colitis

31 March 2020

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Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model

31 March 2020

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Involvement of interleukin-21 in the regulation of colitis-associated colon cancer

31 March 2020

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IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

31 March 2020

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Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis.

31 March 2020

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Distinct profiles of effector cytokines mark the different phases of Crohn's disease

31 March 2020

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Compartmentalized expression of Th1 and Th17 cytokines in pediatric inflammatory bowel diseases.

31 March 2020

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Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases

31 March 2020

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In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease

31 March 2020

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A phase 2 study of tofacitinib, an oral Janus kinase inhibitor, in patients with Crohn's disease

31 March 2020

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Two heads are better than one.

31 March 2020

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Orally administered L. lactis secreting an anti-TNF Nanobody demonstrate efficacy in chronic colitis

31 March 2020

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IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis

31 March 2020

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12 December 2020

Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution

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12 December 2020

Role of the IL-23/IL-17 axis in Crohn's disease

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12 December 2020

Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5.

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12 December 2020

Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis

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12 December 2020

Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa

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12 December 2020

The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6.

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12 December 2020

Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. A novel mechanism of chronic intestinal inflammation

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12 December 2020

Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis

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12 December 2020

Cutting edge: chronic intestinal inflammation in STAT-4 transgenic mice: characterization of disease and adoptive transfer by TNF- plus IFN-gamma-producing CD4+ T cells that respond to bacterial antigens

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12 December 2020

IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells

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12 December 2020

Identifiers

DOI

10.1038/NRI3661

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release_5fvvn6fwjzg4npf4bjehu7jrtu

10 September 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/5fvvn6fwjzg4npf4bjehu7jrtu

24 November 2022

mapped directly with Wikidata item

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