Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age. (Q39413342)

11 September 2017

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Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age. (English)

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11 September 2017

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4

Chinnery PF

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11 September 2017

Elson JL

1

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11 September 2017

Samuels DC

series ordinal

2

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11 September 2017

Turnbull DM

series ordinal

3

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11 September 2017

language of work or name

English

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publication date

6 February 2001

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American Journal of Human Genetics

11 September 2017

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11 September 2017

68

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11 September 2017

3

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11 September 2017

802-806

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Role of adenine nucleotide translocator 1 in mtDNA maintenance

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1274494

Mitochondrial diseases in man and mouse

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1274494

Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1274494

Mutations in mitochondrial DNA accumulate differentially in three different human tissues during ageing

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1274494

A proposed refinement of the mitochondrial free radical theory of aging

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1274494

A new mtDNA mutation showing accumulation with time and restriction to skeletal muscle

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1274494

In situ localization of mitochondrial DNA replication in intact mammalian cells

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1274494

The mutation rate of the human mtDNA deletion mtDNA4977

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1274494

Detection of a specific mitochondrial DNA deletion in tissues of older humans

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1274494

Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1274494

Marked replicative advantage of human mtDNA carrying a point mutation that causes the MELAS encephalomyopathy

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1274494

Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1274494

Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1274494

Induction of a particular deletion in mitochondrial DNA by X rays depends on the inherent radiosensitivity of the cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1274494

Mitochondrial DNA maintenance in vertebrates

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1274494

Dynamics of mitochondria in living cells: shape changes, dislocations, fusion, and fission of mitochondria

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1274494

Mitochondrial genetics: a paradigm for aging and degenerative diseases?

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1274494

Relaxed replication of mtDNA: A model with implications for the expression of disease

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1274494

Mammalian mitochondrial genetics: heredity, heteroplasmy and disease

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1274494

Mitochondrial DNA mutations and pathogenesis

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1274494

A direct repeat is a hotspot for large-scale deletion of human mitochondrial DNA.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1274494

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1274494

Mouse L cell mitochondrial DNA molecules are selected randomly for replication throughout the cell cycle

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1274494

High direct estimate of the mutation rate in the mitochondrial genome of Caenorhabditis elegans.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1274494

Mitochondrial DNA and RNA processing in MELAS.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1274494

Apparent Turnover of Mitochondrial Deoxyribonucleic Acid and Mitochondrial Phospholipids in the Tissues of the Rat

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1274494

Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: an age-related alteration

21 August 2018

1 reference

12 December 2020

Polymyositis with cytochrome oxidase negative muscle fibres. Early quadriceps weakness and poor response to immunosuppressive therapy

1 reference

12 December 2020

Role of mitochondrial DNA mutations in human aging: implications for the central nervous system and muscle

1 reference

12 December 2020

Neuropathological and histochemical changes in a multiple mitochondrial DNA deletion disorder

1 reference

12 December 2020

Identifiers

DOI

10.1086/318801

1 reference

11 September 2017

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11 September 2017

PubMed publication ID

11179029

1 reference