Induced expression of p16(INK4a) inhibits both CDK4- and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes (Q39444837)

12 September 2017

Induced expression of p16(INK4a) inhibits both CDK4- and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes (English)

1 reference

12 September 2017

B B McConnell

1

1 reference

12 September 2017

F J Gregory

2

1 reference

12 September 2017

F J Stott

3

1 reference

12 September 2017

E Hara

4

1 reference

12 September 2017

G Peters

5

1 reference

12 September 2017

language of work or name

English

0 references

publication date

1 March 1999

1 reference

Molecular and Cellular Biology

12 September 2017

1 reference

12 September 2017

19

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12 September 2017

3

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12 September 2017

1981-1989

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describes a project that uses

12 September 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC83991/fullTextXML

inferred from PubMed Central ID database lookup

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

12 September 2017

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Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4

12 September 2017

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Mechanisms of cyclin-dependent kinase inactivation by progestins

12 September 2017

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Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations

12 September 2017

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Structure of the cyclin-dependent kinase inhibitor p19Ink4d

12 September 2017

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Interaction between Cdc37 and Cdk4 in human cells

12 September 2017

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Transforming growth factor beta stabilizes p15INK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells

12 September 2017

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New functional activities for the p21 family of CDK inhibitors

12 September 2017

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The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2

12 September 2017

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The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2

12 September 2017

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Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

12 September 2017

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12 September 2017

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Cyclin-binding motifs are essential for the function of p21CIP1

12 September 2017

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Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4

12 September 2017

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Physical interaction of mammalian CDC37 with CDK4

12 September 2017

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Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex

12 September 2017

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Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4

12 September 2017

1 reference

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Biochemical characterization of p16INK4- and p18-containing complexes in human cell lines

12 September 2017

1 reference

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Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

12 September 2017

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Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation

12 September 2017

1 reference

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Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

12 September 2017

1 reference

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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

12 September 2017

1 reference

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p21 is a universal inhibitor of cyclin kinases

12 September 2017

1 reference

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Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes

12 September 2017

1 reference

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

12 September 2017

1 reference

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Identification of G1 kinase activity for cdk6, a novel cyclin D partner

12 September 2017

1 reference

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D-type cyclin-dependent kinase activity in mammalian cells

12 September 2017

1 reference

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p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

12 September 2017

1 reference

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p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

12 September 2017

1 reference

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Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

12 September 2017

1 reference

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Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

Deletion of p16 and p15 genes in brain tumors

12 September 2017

1 reference

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Mutations and altered expression of p16INK4 in human cancer.

12 September 2017

1 reference

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Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes

12 September 2017

1 reference

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Inhibitors of mammalian G1 cyclin-dependent kinases

12 September 2017

1 reference

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Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

Genomic structure, expression and mutational analysis of the P15 (MTS2) gene

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

Inhibition of cyclin-dependent kinases by p21

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

Growth suppression by p16ink4 requires functional retinoblastoma protein

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

p53 functions as a cell cycle control protein in osteosarcomas

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

Requirement of cyclin E-Cdk2 inhibition in p16(INK4a)-mediated growth suppression

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

Analysis of wild-type and mutant p21WAF-1 gene activities

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

Independent induction of senescence by p16INK4a and p21CIP1 in spontaneously immortalized human fibroblasts

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

Identification of the active region of the DNA synthesis inhibitory gene p21Sdi1/CIP1/WAF1.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

Induction of senescence in human malignant glioma cells by p16INK4A.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

Features of macrophage differentiation induced by p19INK4d, a specific inhibitor of cyclin D-dependent kinases

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

Cyclin-dependent kinase-2 (Cdk2) forms an inactive complex with cyclin D1 since Cdk2 associated with cyclin D1 is not phosphorylated by Cdk7-cyclin-H.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

Cyclin D2 is a moderately oscillating nucleoprotein required for G1 phase progression in specific cell types

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

Elevated p16 at senescence and loss of p16 at immortalization in human papillomavirus 16 E6, but not E7, transformed human uroepithelial cells.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

The p16INK4a/CDKN2A tumor suppressor and its relatives.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

p21 contains independent binding sites for cyclin and cdk2: both sites are required to inhibit cdk2 kinase activity.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

Inhibition of ras-induced proliferation and cellular transformation by p16INK4.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83991

Identification of binding domains on the p21Cip1 cyclin-dependent kinase inhibitor

21 August 2018

1 reference

12 December 2020

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

1 reference

12 December 2020

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta

1 reference

12 December 2020

Multiple mechanisms of p16INK4A inactivation in non-small cell lung cancer cell lines

1 reference

12 December 2020

Differential CDK-inhibitor gene expression in aging human diploid fibroblasts

1 reference

12 December 2020

Association of CDKN2A/p16INK4A with human head and neck keratinocyte replicative senescence: relationship of dysfunction to immortality and neoplasia.

1 reference

12 December 2020

Formation of p27-CDK complexes during the human mitotic cell cycle

1 reference

12 December 2020

Ankyrin for clues about the function of p16INK4a

1 reference

12 December 2020

Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein

1 reference

12 December 2020

Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts

1 reference

12 December 2020

Abundance and subcellular localisation of cyclin D3 in human tumours

1 reference

12 December 2020

Identifiers

DOI

10.1128/MCB.19.3.1981

1 reference

12 September 2017

1 reference

12 September 2017

PubMed publication ID

10022885

1 reference