p21-activated kinase 1 plays a critical role in cellular activation by Nef. (Q39451991)

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4 November 2019

title

p21-activated kinase 1 plays a critical role in cellular activation by Nef (English)

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4 November 2019

1

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4 November 2019

Matthias Geyer

4

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4 November 2019

author name string

X Lu

2

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4 November 2019

J A Frost

3

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4 November 2019

B Jiang

5

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4 November 2019

W Luo

6

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4 November 2019

A Abo

7

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4 November 2019

A S Alberts

8

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4 November 2019

B M Peterlin

9

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4 November 2019

language of work or name

English

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publication date

1 April 2000

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Molecular and Cellular Biology

4 November 2019

published in

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4 November 2019

volume

20

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4 November 2019

issue

7

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4 November 2019

page(s)

2619-2627

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Emerging from the Pak: the p21-activated protein kinase family.

4 November 2019

cites work

1 reference

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Identification of the Nef-associated kinase as p21-activated kinase 2

12 September 2017

1 reference

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Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions

12 September 2017

1 reference

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Functions of lipid rafts in biological membranes

12 September 2017

1 reference

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The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

12 September 2017

1 reference

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PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia

12 September 2017

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SH3-Domain binding function of HIV-1 Nef is required for association with a PAK-related kinase

12 September 2017

1 reference

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Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation

12 September 2017

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The p21Rac/Cdc42-activated kinases (PAKs).

12 September 2017

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The Cdc42/Rac interactive binding region motif of the Wiskott Aldrich syndrome protein (WASP) is necessary but not sufficient for tight binding to Cdc42 and structure formation

12 September 2017

1 reference

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Role of the SH3-ligand domain of simian immunodeficiency virus Nef in interaction with Nef-associated kinase and simian AIDS in rhesus macaques

12 September 2017

1 reference

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Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4

12 September 2017

1 reference

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Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules

12 September 2017

1 reference

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Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes

12 September 2017

1 reference

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Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells

12 September 2017

1 reference

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Association of human immunodeficiency virus Nef protein with actin is myristoylation dependent and influences its subcellular localization.

12 September 2017

1 reference

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Lck regulates Vav activation of members of the Rho family of GTPases

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85477

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85477

Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase family

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85477

Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain

12 September 2017

1 reference

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Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

12 September 2017

1 reference

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Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85477

Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85477

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4

12 September 2017

1 reference

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Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

12 September 2017

1 reference

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Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis

12 September 2017

1 reference

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Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell

12 September 2017

1 reference

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Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients

12 September 2017

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Importance of the nef gene for maintenance of high virus loads and for development of AIDS

12 September 2017

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Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

12 September 2017

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A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1.

12 September 2017

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Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways

14 September 2017

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The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light.

14 September 2017

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CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1.

25 September 2017

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RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase

25 September 2017

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A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity

25 September 2017

1 reference

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The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation.

25 September 2017

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Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity

25 September 2017

1 reference

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Membrane compartmentation is required for efficient T cell activation.

15 June 2018

1 reference

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Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques

15 June 2018

1 reference

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Myristoylation-enhanced binding of the HIV-1 Nef protein to T cell skeletal matrix.

15 June 2018

1 reference

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Activation of Ste20 by Nef from human immunodeficiency virus induces cytoskeletal rearrangements and downstream effector functions in Saccharomyces cerevisiae

15 June 2018

1 reference

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Activation of RhoA and SAPK/JNK signalling pathways by the RhoA-specific exchange factor mNET1.

21 August 2018

1 reference

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HIV-1 Nef association with cellular serine kinase correlates with enhanced virion infectivity and efficient proviral DNA synthesis

21 August 2018

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12 December 2020

Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2

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12 December 2020

Identification of the binding surface on Cdc42Hs for p21-activated kinase

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12 December 2020

HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization

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12 December 2020

The N-Terminus of Nef from HIV-1/SIV Associates with a Protein Complex Containing Lck and a Serine Kinase

1 reference

12 December 2020

10.1128/MCB.20.7.2619-2627.2000

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10713183%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10713183%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

PubMed publication ID

10713183

1 reference