Cyr61 expression in osteosarcoma indicates poor prognosis and promotes intratibial growth and lung metastasis in mice. (Q39462703)

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14 February 2020

title

Cyr61 expression in osteosarcoma indicates poor prognosis and promotes intratibial growth and lung metastasis in mice (English)

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14 February 2020

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6

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14 February 2020

Thorsten Jentzsch

7

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14 February 2020

author name string

Adam A Sabile

1

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14 February 2020

Matthias J E Arlt

2

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14 February 2020

Roman Muff

3

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14 February 2020

Beata Bode

4

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14 February 2020

Bettina Langsam

5

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14 February 2020

Gabor J Puskas

8

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14 February 2020

Walter Born

9

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14 February 2020

Bruno Fuchs

10

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14 February 2020

language of work or name

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1 January 2012

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Journal of Bone and Mineral Research

14 February 2020

published in

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14 February 2020

volume

27

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14 February 2020

issue

1

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14 February 2020

page(s)

58-67

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Primary metastatic osteosarcoma: presentation and outcome of patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols

14 February 2020

cites work

1 reference

Pattern of disease recurrence and prognostic factors in patients with osteosarcoma treated with contemporary chemotherapy

21 January 2018

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Osteosarcoma: anatomic and histologic variants

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The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis

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Modeling metastasis in vivo

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Ezrin in osteosarcoma: comparison between conventional high-grade and central low-grade osteosarcoma

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Cyr61, a product of a growth factor-inducible immediate-early gene, promotes cell proliferation, migration, and adhesion

21 January 2018

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CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth

21 January 2018

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Adhesion of human umbilical vein endothelial cells to the immediate-early gene product Cyr61 is mediated through integrin alphavbeta3.

21 January 2018

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Human CYR61-mediated enhancement of bFGF-induced DNA synthesis in human umbilical vein endothelial cells

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The CCN family of angiogenic regulators: the integrin connection

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Functions and mechanisms of action of CCN matricellular proteins

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Breast cancer. Cyr61 is overexpressed, estrogen-inducible, and associated with more advanced disease

21 January 2018

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Differential expression of the CCN family members Cyr61, CTGF and Nov in human breast cancer.

21 January 2018

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Levels of expression of CYR61 and CTGF are prognostic for tumor progression and survival of individuals with gliomas

21 January 2018

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CCN proteins and cancer: two to tango

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Ovarian carcinomas: CCN genes are aberrantly expressed and CCN1 promotes proliferation of these cells

21 January 2018

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Cyr61, a member of CCN family, is a tumor suppressor in non-small cell lung cancer

21 January 2018

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Cyr61 suppresses growth of human endometrial cancer cells

21 January 2018

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Expression of Cyr61, CTGF, and WISP-1 correlates with clinical features of lung cancer

21 January 2018

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CYR61 downregulation correlates with tumor progression by promoting MMP-7 expression in human gastric carcinoma

21 January 2018

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Involvement of hypoxia-inducing factor-1alpha-dependent plasminogen activator inhibitor-1 up-regulation in Cyr61/CCN1-induced gastric cancer cell invasion

21 January 2018

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Cyr61, a member of ccn (connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed) family, predicts survival of patients with endometrial cancer of endometrioid subtype.

21 January 2018

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CYR61 downregulation reduces osteosarcoma cell invasion, migration, and metastasis.

21 January 2018

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Tissue microarrays for high-throughput molecular profiling of tumor specimens

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A new technique for the assay of infectivity of human adenovirus 5 DNA

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Prognostic value of CCN3 in osteosarcoma

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Decreased expression of Cyr61 is associated with prostate cancer recurrence after surgical treatment

21 January 2018

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A nude mouse model of human osteosarcoma lung metastases for evaluating new therapeutic strategies

21 January 2018

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Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

21 January 2018

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FAK is the upstream signal protein of the phosphatidylinositol 3-kinase-Akt survival pathway in hydrogen peroxide-induced apoptosis of a human glioblastoma cell line

21 January 2018

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Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signalling.

21 January 2018

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Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343

21 January 2018

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Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and beta-catenin-TCF/Lef signaling pathways

21 January 2018

1 reference

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

21 January 2018

1 reference

Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3)

21 January 2018

1 reference

The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblasts

21 January 2018

1 reference

CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain

21 January 2018

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21 January 2018

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