Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin (Q39497589)

12 September 2017

Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin (English)

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12 September 2017

6

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15

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A Martinez

5

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author name string

D Huertas

1

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12 September 2017

M Soler

2

1 reference

12 September 2017

J Moreto

3

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12 September 2017

A Villanueva

4

1 reference

12 September 2017

M Charlton

7

1 reference

12 September 2017

D Moffat

8

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12 September 2017

S Patel

9

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12 September 2017

J McDermott

10

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12 September 2017

J Owen

11

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12 September 2017

D Brotherton

12

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12 September 2017

D Krige

13

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12 September 2017

S Cuthill

14

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12 September 2017

language of work or name

English

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publication date

1 August 2011

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12 September 2017

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12 September 2017

31

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11

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1408-1418

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describes a project that uses

12 September 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3312407/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Aberrant epigenetic landscape in cancer: how cellular identity goes awry

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Survivin reads phosphorylated histone H3 threonine 3 to activate the mitotic kinase Aurora B.

12 September 2017

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Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis

12 September 2017

1 reference

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Current and future management options for myelodysplastic syndromes

12 September 2017

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Histone deacetylase inhibitors: a chemical genetics approach to understanding cellular functions

12 September 2017

1 reference

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Azacitidine for treatment of patients with myelodysplastic syndromes (MDS): practical recommendations of the German MDS Study Group

12 September 2017

1 reference

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Mechanisms of chromosomal instability.

12 September 2017

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Polo-like kinase inhibitors: an emerging opportunity for cancer therapeutics.

12 September 2017

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Structure and functional characterization of the atypical human kinase haspin

12 September 2017

1 reference

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Crystal structure of the catalytic domain of Haspin, an atypical kinase implicated in chromatin organization

12 September 2017

1 reference

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Studies of haspin-depleted cells reveal that spindle-pole integrity in mitosis requires chromosome cohesion

12 September 2017

1 reference

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Antitumor antibiotic fostriecin covalently binds to cysteine-269 residue of protein phosphatase 2A catalytic subunit in mammalian cells

12 September 2017

1 reference

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Histone deacetylase inhibitors in cancer therapy

12 September 2017

1 reference

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Histone deacetylase inhibitors: current status and overview of recent clinical trials

12 September 2017

1 reference

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Aurora-A and hBora join the game of Polo.

12 September 2017

1 reference

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The promises and pitfalls of epigenetic therapies in solid tumours

12 September 2017

1 reference

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The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction

12 September 2017

1 reference

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Identification of small molecule inhibitors of the mitotic kinase haspin by high-throughput screening using a homogeneous time-resolved fluorescence resonance energy transfer assay

12 September 2017

1 reference

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Aurora kinases and their inhibitors: more than one target and one drug

12 September 2017

1 reference

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Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells

12 September 2017

1 reference

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Centromeric Aurora-B activation requires TD-60, microtubules, and substrate priming phosphorylation

12 September 2017

1 reference

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CDK inhibitors in cancer therapy: what is next?

12 September 2017

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Pharmacological and functional comparison of the polo-like kinase family: insight into inhibitor and substrate specificity

12 September 2017

1 reference

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Identification of griseofulvin as an inhibitor of centrosomal clustering in a phenotype-based screen

12 September 2017

1 reference

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The spindle-assembly checkpoint in space and time

12 September 2017

1 reference

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Angiogenesis: an organizing principle for drug discovery?

12 September 2017

1 reference

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Chromatin modifications and their function

12 September 2017

1 reference

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The epigenomics of cancer

12 September 2017

1 reference

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Regulation of mitotic chromosome cohesion by Haspin and Aurora B.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3312407

Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1

12 September 2017

1 reference

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Anaphase topsy-turvy: Cdk1 a securin, separase a CKI.

12 September 2017

1 reference

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The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3312407

VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

12 September 2017

1 reference

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Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia

12 September 2017

1 reference

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Haspin-like proteins: a new family of evolutionarily conserved putative eukaryotic protein kinases

12 September 2017

1 reference

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Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes

12 September 2017

1 reference

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Aurora kinase inhibitors--rising stars in cancer therapeutics?

12 September 2017

1 reference

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Polo-like kinase 1 (Plk1) as a novel drug target in chronic myeloid leukemia: overriding imatinib resistance with the Plk1 inhibitor BI 2536.

12 September 2017

1 reference

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The aurora B kinase inhibitor AZD1152 sensitizes cancer cells to fractionated irradiation and induces mitotic catastrophe

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3312407

AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells in vitro and in vivo

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3312407

Identification of (1H)-pyrroles as histone deacetylase inhibitors with antitumoral activity.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3312407

Proadrenomedullin NH2-terminal 20 peptide is a potent angiogenic factor, and its inhibition results in reduction of tumor growth

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3312407

Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3312407

Two Histone Marks Establish the Inner Centromere and Chromosome Bi-Orientation

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3312407

K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3312407

Validating Aurora B as an anti-cancer drug target.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3312407

Molecular diagnosis of Burkitt's lymphoma

21 August 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3312407

21 August 2018

https://api.crossref.org/works/10.1038%2FONC.2011.335

Fostriecin-mediated G2-M-phase growth arrest correlates with abnormal centrosome replication, the formation of aberrant mitotic spindles, and the inhibition of serine/threonine protein phosphatase activity

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21804608

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2011.335

1 reference

12 September 2017

1 reference

12 September 2017

PubMed publication ID

21804608

1 reference