Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence (Q39631945)

13 September 2017

title

Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence (English)

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13 September 2017

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26 August 2024

1

P. Rai

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26 August 2024

3

D. G A. Burton

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26 August 2024

5

T. T. Onder

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26 August 2024

author name string

J. J. Young

series ordinal

2

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26 August 2024

M. G. Giribaldi

series ordinal

4

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26 August 2024

R. A. Weinberg

series ordinal

6

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26 August 2024

language of work or name

English

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publication date

15 November 2010

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full work available at URL

13 September 2017

https://www.nature.com/articles/onc2010520.pdf

file format

Portable Document Format

online access status

open access

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https://www.nature.com/articles/onc2010520.pdf

26 August 2024

file format

Portable Document Format

1 reference

https://api.crossref.org/works/10.1038/ONC.2010.520

https://www.nature.com/articles/onc2010520

26 August 2024

1 reference

https://api.crossref.org/works/10.1038/ONC.2010.520

26 August 2024

1 reference

13 September 2017

volume

30

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13 September 2017

issue

12

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13 September 2017

page(s)

1489-1496

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

13 September 2017

cites work

1 reference

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Normal human fibroblasts are resistant to RAS-induced senescence

21 January 2018

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

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The level of 8-oxo-7,8-dihydro-2'-deoxyguanosine is positively correlated with the size of the labile iron pool in human lymphocytes

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The nucleotide pool is a significant target for oxidative stress

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Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts

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Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents

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Transfection of v-rasH DNA into MCF-7 human breast cancer cells bypasses dependence on estrogen for tumorigenicity

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Mechanism of guanine-specific DNA damage by oxidative stress and its role in carcinogenesis and aging

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Labile iron pool: the main determinant of cellular response to oxidative stress

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The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence.

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The superoxide-generating oxidase Nox1 is functionally required for Ras oncogene transformation.

21 January 2018

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Mitochondrial dysfunction contributes to oncogene-induced senescence.

21 January 2018

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Molecular genetics and structural biology of human MutT homolog, MTH1.

21 January 2018

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Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis

21 January 2018

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Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

21 January 2018

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Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence

21 January 2018

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Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis.

21 January 2018

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Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening

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Lentivirus-delivered stable gene silencing by RNAi in primary cells

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Direct detection of 8-oxodeoxyguanosine and 8-oxoguanine by avidin and its analogues

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Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

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Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

21 January 2018

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RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels

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Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells

21 January 2018

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In vitro evidence for the recognition of 8-oxoGTP by Ras, a small GTP-binding protein.

21 January 2018

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Transcriptome analysis of microdissected pancreatic intraepithelial neoplastic lesions

21 January 2018

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Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.520

c-K-ras overexpression is characteristic for metastases derived from a methylcholanthrene-induced fibrosarcoma.

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/ONC.2010.520

1 reference

13 September 2017

1 reference