p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug (Q39850223)

15 September 2017

title

p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug. (English)

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15 September 2017

Shu-Ping Wang

1

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15 September 2017

Wen-Lung Wang

2

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15 September 2017

Yih-Leong Chang

3

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15 September 2017

Chen-Tu Wu

4

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15 September 2017

Yu-Chih Chao

5

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15 September 2017

Shih-Han Kao

6

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15 September 2017

Ang Yuan

7

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15 September 2017

Chung-Wu Lin

8

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15 September 2017

Shuenn-Chen Yang

9

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15 September 2017

Wing-Kai Chan

10

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15 September 2017

Ker-Chau Li

11

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15 September 2017

Tse-Ming Hong

12

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15 September 2017

Pan-Chyr Yang

13

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15 September 2017

publication date

17 May 2009

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15 September 2017

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15 September 2017

volume

11

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15 September 2017

issue

6

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15 September 2017

page(s)

694-704

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Tumor metastasis: mechanistic insights and clinical challenges

15 September 2017

cites work

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The p53-Mdm2 module and the ubiquitin system.

21 January 2018

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p53 in health and disease

21 January 2018

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21 January 2018

Surfing the p53 network

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Assessing TP53 status in human tumours to evaluate clinical outcome

21 January 2018

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Expression of E-cadherin and its relation to the p53 protein status in human breast carcinomas.

21 January 2018

1 reference

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

21 January 2018

1 reference

Negative regulation of chemokine receptor CXCR4 by tumor suppressor p53 in breast cancer cells: implications of p53 mutation or isoform expression on breast cancer cell invasion.

21 January 2018

1 reference

Loss of p53 and Ink4a/Arf cooperate in a cell autonomous fashion to induce metastasis of hepatocellular carcinoma cells

21 January 2018

1 reference

The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation

21 January 2018

1 reference

Complex networks orchestrate epithelial-mesenchymal transitions

21 January 2018

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Clinical, cellular, and molecular aspects of cancer invasion

21 January 2018

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High-throughput tissue microarray analysis used to evaluate biology and prognostic significance of the E-cadherin pathway in non-small-cell lung cancer.

21 January 2018

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E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells

21 January 2018

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A causal role for E-cadherin in the transition from adenoma to carcinoma

21 January 2018

1 reference

The snail superfamily of zinc-finger transcription factors

21 January 2018

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The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors

21 January 2018

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Transcription repressor slug promotes carcinoma invasion and predicts outcome of patients with lung adenocarcinoma

21 January 2018

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Slug is overexpressed in gastric carcinomas and may act synergistically with SIP1 and Snail in the down-regulation of E-cadherin.

21 January 2018

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Slug expression is an independent prognostic parameter for poor survival in colorectal carcinoma patients

21 January 2018

1 reference

Expression of the transcription factors snail, slug, and twist and their clinical significance in human breast cancer

21 January 2018

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The melanocyte differentiation program predisposes to metastasis after neoplastic transformation

21 January 2018

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Living with p53, dying of p53.

21 January 2018

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p53 and apoptosis: it's not just in the nucleus anymore

21 January 2018

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Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress

21 January 2018

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The oncogenic roles of p53 mutants in mouse models

21 January 2018

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The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma

21 January 2018

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Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis.

21 January 2018

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Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma

21 January 2018

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Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation

21 January 2018

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Revisions in the International System for Staging Lung Cancer

21 January 2018

1 reference

Clonality and prognostic implications of p53 and epidermal growth factor receptor somatic aberrations in multiple primary lung cancers.

21 January 2018

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Selection of invasive and metastatic subpopulations from a human lung adenocarcinoma cell line

21 January 2018

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Mouse cDNA microarray analysis uncovers Slug targets in mouse embryonic fibroblasts

21 January 2018

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Tumour-associated E-cadherin mutations alter cellular morphology, decrease cellular adhesion and increase cellular motility

21 January 2018

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Extinction of E-cadherin expression in breast cancer via a dominant repression pathway acting on proximal promoter elements

21 January 2018

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12 December 2020

Aberrant p53 expression correlates with expression of vascular endothelial growth factor mRNA and interleukin-8 mRNA and neoangiogenesis in non-small-cell lung cancer

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12 December 2020

The SLUG zinc-finger protein represses E-cadherin in breast cancer

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12 December 2020

Gain-of-function mutations of the p53 gene induce lymphohematopoietic metastatic potential and tissue invasiveness

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12 December 2020

Slug Expression in the E-cadherin preserved tumors is related to prognosis in patients with esophageal squamous cell carcinoma

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12 December 2020

Progression of carcinoma cells is associated with alterations in chromatin structure and factor binding at the E-cadherin promoter in vivo

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12 December 2020

Prognostic Significance of p53 Mutation and p53 Overexpression in Advanced Epithelial Ovarian Cancer: A Gynecologic Oncology Group Study

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12 December 2020

Expression pattern of the cell adhesion molecules. E-cadherin, P-cadherin and alpha 6 beta 4 intergrin is altered in pre-malignant skin tumors of p53-deficient mice

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12 December 2020

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

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12 December 2020

The p53/p63/p73 family of transcription factors: overlapping and distinct functions.

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12 December 2020

Identifiers

DOI

10.1038/NCB1875

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Dimensions Publication ID

15 September 2017

1039659582

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