HIF hydroxylation and cellular oxygen sensing (Q30164092)

9 June 2017

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title

HIF hydroxylation and cellular oxygen sensing (English)

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9 June 2017

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Peter J Ratcliffe

2

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author name string

Eric Metzen

series ordinal

1

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9 June 2017

publication date

1 March 2004

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9 June 2017

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9 June 2017

volume

385

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9 June 2017

issue

3-4

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9 June 2017

page(s)

223-230

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Hypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm

9 June 2017

cites work

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

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The subtle side to hypoxia inducible factor (HIFalpha) regulation

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The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses.

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A conserved family of prolyl-4-hydroxylases that modify HIF

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Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha

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Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells

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Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

21 January 2018

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HIF-1alpha is essential for myeloid cell-mediated inflammation

21 January 2018

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Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation

21 January 2018

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Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway

21 January 2018

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The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen

21 January 2018

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Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha

21 January 2018

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A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

21 January 2018

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Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.

21 January 2018

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

21 January 2018

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Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2004.016

HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

HIF-1 as a target for drug development

21 January 2018

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Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein

21 January 2018

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Synergistic activation of transcription by CBP and p53

21 January 2018

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Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Hypoxia-inducible factor and its biomedical relevance

21 January 2018

1 reference

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Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

21 January 2018

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Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Identification of hypoxia-inducible factor 1 ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Mammalian EGLN genes have distinct patterns of mRNA expression and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5' enhancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Regulation of hypoxia-inducible factor-1alpha by nitric oxide through mitochondria-dependent and -independent pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

ERK activation upon hypoxia: involvement in HIF-1 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Characterization of the iron- and 2-oxoglutarate-binding sites of human prolyl 4-hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilatation after myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Regulation of angiogenesis by hypoxia: role of the HIF system

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1 alpha is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association with p300/CBP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

HIF-1 alpha protein as a target for S-nitrosation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Characterization and comparative analysis of the EGLN gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Structure of a cephalosporin synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Tumor necrosis factor-alpha causes accumulation of a ubiquitinated form of hypoxia inducible factor-1alpha through a nuclear factor-kappaB-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Hypoxic Regulation of Lactate Dehydrogenase A

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2004.016

Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

21 January 2018

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1515/BC.2004.016

Identification and characterization of a nuclease specific for the 3' end of the U6 small nuclear RNA

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1515/BC.2004.016

Hypoxia-inducible Factor-1 Mediates Transcriptional Activation of the Heme Oxygenase-1 Gene in Response to Hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1515/BC.2004.016

Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1515/BC.2004.016

Normoxic induction of the hypoxia-inducible factor 1alpha by insulin and interleukin-1beta involves the phosphatidylinositol 3-kinase pathway

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1515/BC.2004.016

Dissecting hypoxia-dependent and hypoxia-independent steps in the HIF-1alpha activation cascade: implications for HIF-1alpha gene therapy

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1515/BC.2004.016

IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1515/BC.2004.016

Hypoxia-inducible factor 1: master regulator of O2 homeostasis

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1515/BC.2004.016

Identifiers

DOI

10.1515/BC.2004.016

1 reference

9 June 2017

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