Mutations at the dimer, hexamer, and receptor-binding surfaces of insulin independently affect insulin-insulin and insulin-receptor interactions (Q30360537)

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scientific article published on February 18, 1992

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English	Mutations at the dimer, hexamer, and receptor-binding surfaces of insulin independently affect insulin-insulin and insulin-receptor interactions	scientific article published on February 18, 1992

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scholarly article

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Europe PubMed Central

PubMed publication ID

20 June 2017

Mutations at the dimer, hexamer, and receptor-binding surfaces of insulin independently affect insulin-insulin and insulin-receptor interactions (English)

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10.1021/BI00121A025

https://api.crossref.org/works/10.1021/BI00121A025

12 November 2022

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10.1021/BI00121A025

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S. E. Shoelson

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1737029

12 November 2022

Z. X. Lu

2

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12 November 2022

L. Parlautan

3

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12 November 2022

C. S. Lynch

4

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12 November 2022

M. A. Weiss

5

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12 November 2022

language of work or name

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publication date

1 February 1992

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Europe PubMed Central

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20 June 2017

18 February 1992

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National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1737029

12 November 2022

number of pages

11

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full work available at URL

https://pubs.acs.org/doi/pdf/10.1021/bi00121a025

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10.1021/BI00121A025

https://api.crossref.org/works/10.1021/BI00121A025

12 November 2022

1 reference

Europe PubMed Central

PubMed publication ID

20 June 2017

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PubMed publication ID

20 June 2017

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Europe PubMed Central

PubMed publication ID

20 June 2017

1757-1767

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Europe PubMed Central

PubMed publication ID

20 June 2017

Structure of Rhombohedral 2 Zinc Insulin Crystals

1

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10.1021/BI00121A025

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12 November 2022

[LeuB24]insulin and [AlaB24]insulin: altered structures and cellular processing of B24-substituted insulin analogs

2

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10.1021/BI00121A025

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12 November 2022

The structure of 2Zn pig insulin crystals at 1.5 A resolution

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10.1021/BI00121A025

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Zinc-free cubic pig insulin: crystallization and structure determination

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10.1021/BI00121A025

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Atomic Positions in Rhombohedral 2-Zinc Insulin Crystals

6

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10.1021/BI00121A025

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1H n.m.r. studies of insulin. Assignment of resonances and properties of tyrosine residues

8

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Monomeric insulins obtained by protein engineering and their medical implications

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Monomeric insulins and their experimental and clinical implications

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Preparation and characterization of desoctapeptide-insulin

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Shortened insulin with enhanced in vitro potency

12

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Phenol stabilizes more helix in a new symmetrical zinc insulin hexamer

13

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X-ray analysis of the single chain B29-A1 peptide-linked insulin molecule. A completely inactive analogue.

14

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Expression of a functional human insulin receptor from a cloned cDNA in Chinese hamster ovary cells

17

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10.1021/BI00121A025

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A shortened insulin with full in vitro potency

18

1 reference

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12 November 2022

Structure-function relationships of shortened [LeuB25]insulins, semisynthetic analogues of a mutant human insulin

19

1 reference

10.1021/BI00121A025

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Insulin receptors: binding kinetics and structure-function relationship of insulin

20

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Zinc binding, circular dichroism, and equilibrium sedimentation studies on insulin (bovine) and several of its derivatives

21

1 reference

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Familial hyperinsulinemia due to a structurally abnormal insulin. Definition of an emerging new clinical syndrome.

22

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Toward the solution structure of human insulin: sequential 2D 1H NMR assignment of a des-pentapeptide analogue and comparison with crystal structure

23

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Thermodynamic identification of stable folding intermediates in the B-subunit of cholera toxin

24

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High resolution 1H-NMR studies of Des-(B26-B30)-insulin; assignment of resonances and properties of aromatic residues

25

1 reference

10.1021/BI00121A025

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12 November 2022

Receptor binding redefined by a structural switch in a mutant human insulin

26

1 reference

10.1021/BI00121A025

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12 November 2022

Semisynthesis and properties of some insulin analogs

29

1 reference

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Semisynthesis and biological properties of the [B24-leucine]-, [B25-leucine[- and [B24-leucine, B25-leucine]-analogues of human insulin

30

1 reference

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An equilibrium ultracentrifuge study of the self-association of bovine insulin

32

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Self-association of des-(B26-B30)-insulin. The effect of Ca2+ and some other divalent cations

34

1 reference

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12 November 2022

Comparison of insulin analogue B9AspB27Glu and soluble human insulin in insulin-treated diabetes

35

1 reference

10.1021/BI00121A025

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12 November 2022

Comparison of subcutaneous soluble human insulin and insulin analogues (AspB9, GluB27; AspB10; AspB28) on meal-related plasma glucose excursions in type I diabetic subjects

36

1 reference

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12 November 2022

Subcutaneous Insulin Absorption Explained by Insulin's Physicochemical Properties: Evidence From Absorption Studies of Soluble Human Insulin and Insulin Analogues in Humans

37

1 reference

10.1021/BI00121A025

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12 November 2022

Complete sequence-specific 1H NMR assignments for human insulin

38

1 reference

10.1021/BI00121A025

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12 November 2022

Characterization of [LeuB-24]- and [LeuB-25]-insulin analogues. Receptor binding and biological activity

39

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Supernormal insulin: [D-PheB24]-insulin with increased affinity for insulin receptors

40

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Receptor binding and biological activity of [SerB24]-insulin, an abnormal mutant insulin

41

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Proton nuclear magnetic resonance study of the B9(Asp) mutant of human insulin. Sequential assignment and secondary structure.

42

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International journal of peptide and protein research

43

27

514

author name string

Kubrick T.

publication date

1986

1 reference

10.1021/BI00121A025

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Soluble, prolonged-acting insulin derivatives. III. Degree of protraction, crystallizability and chemical stability of insulins substituted in positions A21, B13, B23, B27 and B30

45

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Disposition of the phenylalanine B25 side chain during insulin-receptor and insulin-insulin interactions

47

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Conformation of proinsulin. A comparison of insulin and proinsulin self-association at neutral pH.

51

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Receptor-binding region of insulin

53

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The semisynthesis of portions of hen's-egg lysozyme by fragment condensation

54

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A superactive insulin: [B10-aspartic acid]insulin(human).

56

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10.1021/BI00121A025

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12 November 2022

A highly potent insulin: des-(B26-B30)-[AspB10,TyrB25-NH2]insulin(human).

57

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10.1021/BI00121A025

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12 November 2022

Identification of a mutant human insulin predicted to contain a serine-for-phenylalanine substitution

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10.1021/BI00121A025

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Three mutant insulins in man

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Human insulin B24 (Phe----Ser). Secretion and metabolic clearance of the abnormal insulin in man and in a dog model

61

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Binding kinetics of mutated insulin receptors in transfected cells grown in suspension culture: application to the Tyr----Phe 960 insulin receptor mutant

63

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Structural stability in the 4-zinc human insulin hexamer

64

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10.1021/BI00121A025

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Near-ultraviolet tyrosyl circular dichroism of pig insulin monomers, dimers, and hexamers. Dipole-dipole coupling calculations in the monopole approximation

66

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A structurally abnormal insulin causing human diabetes

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Semisynthesis and biological activity of porcine [LeuB24]insulin and [LeuB25]insulin

68

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Two-dimensional NMR and photo-CIDNP studies of the insulin monomer: assignment of aromatic resonances with application to protein folding, structure, and dynamics

69

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10.1021/BI00121A025

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Heteronuclear 2D NMR studies of an engineered insulin monomer: assignment and characterization of the receptor-binding surface by selective 2H and 13C labeling with application to protein design

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Two mutant forms of human insulin. Structural consequences of the substitution of invariant B24- or B25-phenylalanine by leucine

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12 November 2022

Identifiers

10.1021/BI00121A025

1 reference

Europe PubMed Central

PubMed publication ID

20 June 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

20 June 2017

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