Past achievements, current status and future perspectives of studies on 3-hydroxy-3-methylglutaryl-CoA synthase (HMGS) in the mevalonate (MVA) pathway. (Q30360799)

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English	Past achievements, current status and future perspectives of studies on 3-hydroxy-3-methylglutaryl-CoA synthase (HMGS) in the mevalonate (MVA) pathway.	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

20 June 2017

Past achievements, current status and future perspectives of studies on 3-hydroxy-3-methylglutaryl-CoA synthase (HMGS) in the mevalonate (MVA) pathway. (English)

1 reference

Europe PubMed Central

PubMed publication ID

20 June 2017

Andrea Hemmerlin

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24682521%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Dinesh A Nagegowda

4

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24682521%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

7

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24682521%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

author name string

Pan Liao

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24682521%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Hui Wang

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24682521%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Thomas J Bach

5

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PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24682521%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Mingfu Wang

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24682521%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

publication date

30 March 2014

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Europe PubMed Central

PubMed publication ID

20 June 2017

number of pages

18

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based on heuristic

inferred from page(s)

Plant Cell Reports

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24682521%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

33

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24682521%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24682521%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

1005-1022

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24682521%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

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1 reference

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Aspects related to 3-Hydroxy-3-methylglutaryl-CoA synthesis in higher plants

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Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent

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Proteomics of phosphate use and deprivation in plants.

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Rat mitochondrial and cytosolic 3-hydroxy-3-methylglutaryl-CoA synthases are encoded by two different genes

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

Nucleotide sequence of a rat liver cDNA encoding the cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

Aspects related to mevalonate biosynthesis in plants

1 reference

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21 January 2018

Regulation of cholesterol synthesis in rat adrenal gland through coordinate control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase activities

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

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Diurnal regulation of the brassinosteroid-biosynthetic CPD gene in Arabidopsis

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

Divergent regulation of terpenoid metabolism in the trichomes of wild and cultivated tomato species.

1 reference

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21 January 2018

Origins and evolution of isoprenoid lipid biosynthesis in archaea

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21 January 2018

Phytosterols as anticancer compounds

1 reference

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21 January 2018

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

1 reference

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21 January 2018

Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase

1 reference

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21 January 2018

Regulation of the expression of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene. Its role in the control of ketogenesis

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

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3-Hydroxy-3-methylglutaryl-CoA synthase. A role for glutamate 95 in general acid/base catalysis of C-C bond formation.

1 reference

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21 January 2018

Three genes encode 3-hydroxy-3-methylglutaryl-coenzyme A reductase in Hevea brasiliensis: hmg1 and hmg3 are differentially expressed

1 reference

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21 January 2018

Candidate genes involved in tanshinone biosynthesis in hairy roots of Salvia miltiorrhiza revealed by cDNA microarray

1 reference

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21 January 2018

Rate-limiting function of 3-hydroxy-3-methylglutaryl-coenzyme A synthase in ketogenesis

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

Sterol regulation of 3-hydroxy-3-methylglutaryl-coenzyme A synthase gene through a direct interaction between sterol regulatory element binding protein and the trimeric CCAAT-binding factor/nuclear factor Y.

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

Acceleration of cutaneous wound healing by brassinosteroids.

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

A functional genomics approach to tanshinone biosynthesis provides stereochemical insights.

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1.

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

Regulation of the mevalonate pathway

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699

1 reference

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21 January 2018

CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

Sterols regulate development and gene expression in Arabidopsis

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

Effects of mevinolin on cell cycle progression and viability of tobacco BY-2 cells.

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

Cross-talk between the Cytosolic Mevalonate and the Plastidial Methylerythritol Phosphate Pathways in Tobacco Bright Yellow-2 Cells

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

A raison d'être for two distinct pathways in the early steps of plant isoprenoid biosynthesis?

1 reference

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21 January 2018

Th biosynthesis of rubber from beta-hydroxy-beta-methylgluarylcoenzyme A in Hevea brasiliensis latex

1 reference

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21 January 2018

SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2.

1 reference

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21 January 2018

The Rice brassinosteroid-deficient dwarf2 mutant, defective in the rice homolog of Arabidopsis DIMINUTO/DWARF1, is rescued by the endogenously accumulated alternative bioactive brassinosteroid, dolichosterone

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

Cytokinins and shoot development

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

The Arabidopsis FLAKY POLLEN1 gene encodes a 3-hydroxy-3-methylglutaryl-coenzyme A synthase required for development of tapetum-specific organelles and fertility of pollen grains

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

Divergent evolution of the thiolase superfamily and chalcone synthase family.

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

The Metabolism of Isoprenoid Precursors in a Plant System

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

Characterization and expression profile analysis of a new cDNA encoding taxadiene synthase from Taxus media

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

Avian liver 3-hydroxy-3-methylglutaryl-CoA synthase: distinct genes encode the cholesterogenic and ketogenic isozymes

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

The regulation of DWARF4 expression is likely a critical mechanism in maintaining the homeostasis of bioactive brassinosteroids in Arabidopsis

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

Genome organization in Arabidopsis thaliana: a survey for genes involved in isoprenoid and chlorophyll metabolism

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

A role for brassinosteroids in light-dependent development of Arabidopsis

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

Genome-wide identification and characterization of novel genes involved in terpenoid biosynthesis in Salvia miltiorrhiza

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

Evidence for the interaction of avian 3-hydroxy-3-methylglutaryl-CoA synthase histidine 264 with acetoacetyl-CoA.

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

The Influence of Conserved Aromatic Residues in 3-Hydroxy-3-methylglutaryl-CoA Synthase

1 reference

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21 January 2018

Active-site-directed inhibition of 3-hydroxy-3-methylglutaryl coenzyme A synthase by 3-chloropropionyl coenzyme A.

1 reference

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21 January 2018

Active site directed inactivation of rat mammary gland fatty acid synthase by 3-chloropropionyl coenzyme A.

1 reference

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21 January 2018

Isolation and characterization of a cDNA encoding Arabidopsis thaliana 3-hydroxy-3-methylglutaryl-coenzyme A synthase

1 reference

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21 January 2018

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1 reference

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21 January 2018

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1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

Brassica juncea HMG-CoA synthase: localization of mRNA and protein.

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthase

1 reference

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21 January 2018

Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases

1 reference

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21 January 2018

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1 reference

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21 January 2018

Amplification and direct sequencing of a cDNA encoding human cytosolic 3-hydroxy-3-methylglutaryl-coenzyme A synthase

1 reference

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21 January 2018

Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

Cytokinin regulates compound leaf development in tomato.

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

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1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

A visible wavelength spectrophotometric assay suitable for high-throughput screening of 3-hydroxy-3-methylglutaryl-CoA synthase

1 reference

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21 January 2018

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1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

Fasting hypoketotic coma in a child with deficiency of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase.

1 reference

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21 January 2018

The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools

1 reference

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21 January 2018

Binding site for fungal beta-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase

1 reference

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21 January 2018

3-hydroxy-3-methylglutaryl-coenzyme A synthase reaction intermediates: detection of a covalent tetrahedral adduct by differential isotope shift 13C nuclear magnetic resonance spectroscopy

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

Network analysis of the MVA and MEP pathways for isoprenoid synthesis

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

Boosting crop yields with plant steroids.

1 reference

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21 January 2018

Molecular cloning of ozone-inducible protein from Pinus sylvestris L. with high sequence similarity to vertebrate 3-hydroxy-3-methylglutaryl-CoA-synthase

1 reference

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21 January 2018

Inhibition of squalene synthase and squalene epoxidase in tobacco cells triggers an up-regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

Activity and intracellular distribution of enzymes of ketone-body metabolism in rat liver

1 reference

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21 January 2018

Anticancer effects of phytosterols

1 reference

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21 January 2018

An improved simplified high-sensitivity quantification method for determining brassinosteroids in different tissues of rice and Arabidopsis

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

Transcriptome analysis of medicinal plant Salvia miltiorrhiza and identification of genes related to tanshinone biosynthesis

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

Functional diversity of genes for the biosynthesis of paeoniflorin and its derivatives in Paeonia

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

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1 reference

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21 January 2018

Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use

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21 January 2018

Metabolic enzymes of 3-hydroxy-3-methylglutaryl-coenzyme A in Catharanthus roseus

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

Enzymes involved in the metabolism of 3-hydroxy-3-methylglutaryl-coenzyme A in Catharanthus roseus

1 reference

https://api.crossref.org/works/10.1007%2FS00299-014-1592-9

21 January 2018

Amino acid sequence of an active site peptide of avian liver mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/24682521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of Brassica juncea wild-type and mutant HMG-CoA synthase 1 in Arabidopsis up-regulates genes in sterol biosynthesis and enhances sterol production and stress tolerance

1 reference

https://pubmed.ncbi.nlm.nih.gov/24682521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase from the hamster. I. Isolation and sequencing of a full-length cDNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24682521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular and catalytic properties of mitochondrial (ketogenic) 3-hydroxy-3-methylglutaryl coenzyme A synthase of liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/24682521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple sterol regulatory elements in promoter for hamster 3-hydroxy-3-methylglutaryl-coenzyme A synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/24682521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3-Hydroxy-3-methylgutaryl-CoA synthase. Participation of acetyl-S-enzyme and enzyme-S-hydroxymethylgutaryl-SCoA intermediates in the reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/24682521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The reduction of beta-hydroxy-beta-methyl-glutaryl coenzyme A to mevalonic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/24682521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning and tissue expression of human mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/24682521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

F-244 specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/24682521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The antibiotic cerulenin, a novel tool for biochemistry as an inhibitor of fatty acid synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24682521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[The chemical mechanism of acetic acid formation in the liver.]

1 reference

https://pubmed.ncbi.nlm.nih.gov/24682521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthetic pathways from acetate to natural products

1 reference

https://pubmed.ncbi.nlm.nih.gov/24682521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modular Pathway Engineering of Diterpenoid Synthases and the Mevalonic Acid Pathway for Miltiradiene Production

1 reference

https://pubmed.ncbi.nlm.nih.gov/24682521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Farnesol-induced cell death and stimulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in tobacco cv bright yellow-2 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24682521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The biosynthesis of beta-hydroxy-beta-methylglutaryl coenzyme A in yeast. II. The formation of hydroxymethylglutaryl coenzyme A via the condensation of acetyl coenzyme A and acetoacetyl coenzyme A

1 reference

https://pubmed.ncbi.nlm.nih.gov/24682521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Arabidopsis deetiolated2 mutant is blocked early in brassinosteroid biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24682521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of MEP pathway and other inhibitors on the intracellular localization of a plasma membrane-targeted, isoprenylable GFP reporter protein in tobacco BY-2 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24682521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conversion of mevalonic acid to gamma, gamma-dimethylallyl pyrophosphate by Mycoplasma

1 reference

https://pubmed.ncbi.nlm.nih.gov/24682521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular localization of the 3-hydroxy-3-methylglutaryl coenzme A cycle enzymes in liver. Separate cytoplasmic and mitochondrial 3-hydroxy-3-methylglutaryl coenzyme A generating systems for cholesterogenesis and ketogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24682521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the biosynthesis of cholesterol. 10. Mevalonic kinase from liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/24682521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the site of acetyl-S-enzyme formation on avian liver mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/24682521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The biosynthesis of beta-hydroxy-beta-methylglutaryl coenzyme A in yeast. I. Identification and purification of the hydroxymethylglutaryl coenzymecondensing enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/24682521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Origins and early evolution of the mevalonate pathway of isoprenoid biosynthesis in the three domains of life

1 reference

https://pubmed.ncbi.nlm.nih.gov/24682521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydroxymethylglutaryl-CoA reductase, a key enzyme in phytosterol synthesis?

1 reference

https://pubmed.ncbi.nlm.nih.gov/24682521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase from the hamster. II. Isolation of the gene and characterization of the 5' flanking region

1 reference

https://pubmed.ncbi.nlm.nih.gov/24682521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24682521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The biosynthesis of beta-hydroxy-beta-methylglutaryl coenzyme A in yeast. IV. The origin of the thioester bond of beta-hydroxy-beta-methylglutaryl coenzyme A

1 reference

https://pubmed.ncbi.nlm.nih.gov/24682521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The biosynthesis of beta-hydroxy-beta-methylglutaric acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/24682521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3-Hydroxy-3-methylglutaryl coenzyme A synthase. Evidence for an acetyl-S-enzyme intermediate and identification of a cysteinyl sulfhydryl as the site of acetylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24682521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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