Molecular mechanism of endothelial and vascular aging: implications for cardiovascular disease. (Q30381121)

21 June 2017

title

Molecular mechanism of endothelial and vascular aging: implications for cardiovascular disease. (English)

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21 June 2017

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cardiovascular disease

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2

Gianluigi Savarese

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21 June 2017

4

Thomas F Lüscher

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ORCID Public Data File 2021

21 June 2017

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author name string

Giovanni G Camici

series ordinal

1

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21 June 2017

Alexander Akhmedov

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3

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21 June 2017

publication date

4 November 2015

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21 June 2017

published in

European Heart Journal

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21 June 2017

volume

36

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21 June 2017

issue

48

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21 June 2017

page(s)

3392-3403

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2014 ESC/EACTS Guidelines on myocardial revascularization: The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)Developed with the special contribu

21 June 2017

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Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase

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SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks

21 January 2018

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Sirtuins as regulators of metabolism and healthspan

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21 January 2018

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21 January 2018

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The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice

21 January 2018

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Senescence-Induced Oxidative Stress Causes Endothelial Dysfunction

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Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome

21 January 2018

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Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase

21 January 2018

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Regulation of Akt signaling by sirtuins: its implication in cardiac hypertrophy and aging

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Evidence for a common mechanism of SIRT1 regulation by allosteric activators

21 January 2018

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Sirtuin function in aging heart and vessels

21 January 2018

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The p66shc adaptor protein controls oxidative stress response and life span in mammals

21 January 2018

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The mammalian longevity-associated gene product p66shc regulates mitochondrial metabolism

21 January 2018

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Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet.

21 January 2018

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Enhanced age-dependent cerebrovascular dysfunction is mediated by adaptor protein p66Shc.

21 January 2018

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Adaptor protein p66(Shc) mediates hypertension-associated, cyclic stretch-dependent, endothelial damage

21 January 2018

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Deletion of the ageing gene p66(Shc) reduces early stroke size following ischaemia/reperfusion brain injury

21 January 2018

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Post-ischaemic silencing of p66Shc reduces ischaemia/reperfusion brain injury and its expression correlates to clinical outcome in stroke

21 January 2018

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Oxidized low-density lipoprotein activates p66Shc via lectin-like oxidized low-density lipoprotein receptor-1, protein kinase C-beta, and c-Jun N-terminal kinase kinase in human endothelial cells

21 January 2018

1 reference

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Dual role of endothelial nitric oxide synthase in oxidized LDL-induced, p66Shc-mediated oxidative stress in cultured human endothelial cells

21 January 2018

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Diabetes induces p66shc gene expression in human peripheral blood mononuclear cells: relationship to oxidative stress.

21 January 2018

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Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress.

21 January 2018

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Gene silencing of the mitochondrial adaptor p66(Shc) suppresses vascular hyperglycemic memory in diabetes.

21 January 2018

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Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes

21 January 2018

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Expression of the aging gene p66Shc is increased in peripheral blood monocytes of patients with acute coronary syndrome but not with stable coronary artery disease.

21 January 2018

1 reference

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Genetic deletion of the adaptor protein p66Shc increases susceptibility to short-term ischaemic myocardial injury via intracellular salvage pathways.

21 January 2018

1 reference

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The cardioprotective effects elicited by p66(Shc) ablation demonstrate the crucial role of mitochondrial ROS formation in ischemia/reperfusion injury

21 January 2018

1 reference

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The influence of Shc proteins on life span in mice.

21 January 2018

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Multiple facets of junD gene expression are atypical among AP-1 family members

21 January 2018

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JunD activates transcription of the human ferritin H gene through an antioxidant response element during oxidative stress

21 January 2018

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Menin suppresses osteoblast differentiation by antagonizing the AP-1 factor, JunD

21 January 2018

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Induced JunD in intestinal epithelial cells represses CDK4 transcription through its proximal promoter region following polyamine depletion

21 January 2018

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JunD reduces tumor angiogenesis by protecting cells from oxidative stress

21 January 2018

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Distinct functions of junD in cardiac hypertrophy and heart failure

21 January 2018

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Redundancy of myostatin and growth/differentiation factor 11 function

21 January 2018

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Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy

21 January 2018

1 reference

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Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors

21 January 2018

1 reference

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Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats

21 January 2018

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Therapeutic potential of resveratrol: the in vivo evidence

21 January 2018

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Effect of resveratrol administration on metabolic syndrome, insulin sensitivity, and insulin secretion.

21 January 2018

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Effects of resveratrol supplementation on plasma lipids: a systematic review and meta-analysis of randomized controlled trials

21 January 2018

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Caloric restriction and aging: an update

21 January 2018

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Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS.

21 January 2018

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Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

21 January 2018

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Cardioprotective Signature of Short-Term Caloric Restriction

21 January 2018

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Calorie restriction attenuates cardiac remodeling and diastolic dysfunction in a rat model of metabolic syndrome

21 January 2018

1 reference

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Short-Term Caloric Restriction Suppresses Cardiac Oxidative Stress and Hypertrophy Caused by Chronic Pressure Overload

21 January 2018

1 reference

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Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV587

Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study

21 January 2018

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RETRACTED: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet

21 January 2018

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Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans

21 January 2018

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Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial

21 January 2018

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Long-term caloric restriction ameliorates the decline in diastolic function in humans.

21 January 2018

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Longitudinal trajectories of arterial stiffness and the role of blood pressure: the Baltimore Longitudinal Study of Aging.

21 January 2018

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Carotid arterial stiffness and its relationship to exercise intolerance in older patients with heart failure and preserved ejection fraction

21 January 2018

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Aortic stiffness, blood pressure progression, and incident hypertension

21 January 2018

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Vitamin E consumption and the risk of coronary disease in women

21 January 2018

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Vitamin E consumption and the risk of coronary heart disease in men.

21 January 2018

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Alpha-tocopherol supplementation in healthy individuals reduces low-density lipoprotein oxidation but not atherosclerosis: the Vitamin E Atherosclerosis Prevention Study (VEAPS).

21 January 2018

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Randomised trial of alpha-tocopherol and beta-carotene supplements on incidence of major coronary events in men with previous myocardial infarction

21 January 2018

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Dietary cosupplementation with vitamin E and coenzyme Q(10) inhibits atherosclerosis in apolipoprotein E gene knockout mice

21 January 2018

1 reference

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Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial

21 January 2018

1 reference

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Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions

21 January 2018

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Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators

21 January 2018

1 reference

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Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study).

21 January 2018

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Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients

21 January 2018

1 reference

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Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial

21 January 2018

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Angiotensin-converting-enzyme inhibition in stable coronary artery disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV587

Aging, arterial stiffness, and hypertension

21 January 2018

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https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV587

Physiology of local renin-angiotensin systems.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV587

Rethinking the renin-angiotensin system and its role in cardiovascular regulation.

21 January 2018

1 reference

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Enalapril reduces the incidence of diabetes in patients with chronic heart failure: insight from the Studies Of Left Ventricular Dysfunction (SOLVD).

21 January 2018

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Oxidative stress and vascular inflammation in aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV587

Large Artery Stiffening and Remodeling Are Independently Associated With All-Cause Mortality and Cardiovascular Events in Chronic Kidney Disease

21 January 2018

1 reference

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Anti-inflammatory and anti-atherogenic effects of cathechin, caffeic acid and trans-resveratrol in apolipoprotein E deficient mice

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1093/EURHEARTJ/EHV587

1 reference

21 June 2017

1 reference