Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents (Q30406145)

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English	Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents	scientific article

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Europe PubMed Central

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14 October 2017

Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents (English)

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14 October 2017

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Colleen M. Niswender

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Colleen M Niswender

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Craig W. Lindsley

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Craig W Lindsley

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P. Jeffrey Conn

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P Jeffrey Conn

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Michael Bubser

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Meredith J Noetzel

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Meredith J Noetzel

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Atin Lamsal

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Bruce J. Melancon

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Bruce J Melancon

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Michael D Grannan

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Michael Grannan

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Michael S Poslusney

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Michael S Poslusney

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Jürgen Wess

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Nicholas J Brandon

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Nicholas J Brandon

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Carrie K Jones

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Thomas M Bridges

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Ditte Dencker

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Robert W Gould

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J Scott Daniels

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James C Tarr

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Frank W Byers

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Mark E Duggan

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John Dunlop

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Michael W Wood

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Michael R Wood

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publication date

19 August 2014

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ACS Chemical Neuroscience

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920-942

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14 October 2017

M4 mAChR-mediated modulation of glutamatergic transmission at corticostriatal synapses

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Effects of selective activation of M1 and M4 muscarinic receptors on object recognition memory performance in rats

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Antipsychotic drug-like effects of the selective M4 muscarinic acetylcholine receptor positive allosteric modulator VU0152100

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Imaging glutamate in schizophrenia: review of findings and implications for drug discovery

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Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models

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M4 muscarinic receptor knockout mice display abnormal social behavior and decreased prepulse inhibition.

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Muscarinic receptor pharmacology and circuitry for the modulation of cognition.

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Molecular mechanisms of fear learning and memory.

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Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system

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20 June 2018

Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia

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Intact attentional processing but abnormal responding in M1 muscarinic receptor-deficient mice using an automated touchscreen method.

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20 June 2018

Involvement of a subpopulation of neuronal M4 muscarinic acetylcholine receptors in the antipsychotic-like effects of the M1/M4 preferring muscarinic receptor agonist xanomeline.

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Increased cocaine self-administration in M4 muscarinic acetylcholine receptor knockout mice.

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N-methyl-d-aspartate (NMDA) receptor dysfunction or dysregulation: the final common pathway on the road to schizophrenia?

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A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviors

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Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties

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A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning

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Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats.

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Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats

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Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia

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The touchscreen cognitive testing method for rodents: how to get the best out of your rat.

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Impaired discrimination learning in mice lacking the NMDA receptor NR2A subunit.

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An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission

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Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology.

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NMDA receptor hypofunction produces concomitant firing rate potentiation and burst activity reduction in the prefrontal cortex

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20 June 2018

N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl- d -aspartate receptor activity

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Direct and indirect modulation of the N-methyl D-aspartate receptor

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Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats

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Activation of the genetically defined m1 muscarinic receptor potentiates N-methyl-D-aspartate (NMDA) receptor currents in hippocampal pyramidal cells

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Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease

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Effect of the NMDA receptor antagonist, MK-801, on locomotor activity and on the metabolism of dopamine in various brain areas of mice.

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Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse

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Effects of D1 and D2 dopamine receptor antagonists and catecholamine depleting agents on the locomotor stimulation induced by dizocilpine in mice

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A comparison between the non-competitive NMDA antagonist dizocilpine (MK-801) and the competitive NMDA antagonist D-CPPene with regard to dopamine turnover and locomotor-stimulatory properties in mice

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1021/CN500128B

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Europe PubMed Central

PMC publication ID

14 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

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